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  • Open Access

PReS-FINAL-2203: Assessment of sleep problems in children with familial Mediterranean fever

  • 1,
  • 1,
  • 1 and
  • 1
Pediatric Rheumatology201311(Suppl 2):P193

https://doi.org/10.1186/1546-0096-11-S2-P193

Published: 5 December 2013

Keywords

  • Colchicine
  • Sleep Disturbance
  • Sleep Duration
  • Familial Mediterranean Fever
  • Subclinical Inflammation

Objectives

The study aimed to investigate sleep patterns, sleep disturbances and possible factors that are associated with sleep disturbances among children with FMF.

Methods

Forty six FMF patients and 80 age- and sex-matched healthy children were enrolled in the study (Table 1). The patients who had an attack during the last 2 weeks were not included. Demographic data, FMF symptoms, disease duration, dose of colchicine, disease severity score, number of attacks in the last year, MEFV mutation and serum C-reactive protein level were recorded for each patient. Children's Sleep Habits Questionnaire was performed. It is a parent-report questionnaire assessing the typical sleep patterns of children. It includes 33 items measuring sleep disturbances (8 subscales) and 3 three items collecting information about bedtime, wake-up time and sleep duration over a "typical" recent week. A total score of ≥41 defines "clinically significant sleep disturbance".

Table 1

 

FMF patients

Healthy controls

p value

Length of wakings (minute)

9.5 ± 18.6

3.1 ± 3.6

0.026

Total sleep duration (hour)

9 ± 1.4

8.8 ± 1

0.34

Total sleep score

   SUBSCALES

50.1 ± 10.4

46.6 ± 6.6

0.010

Bedtime resistance

Sleep-onset delay

Sleep duration

Sleep anxiety

Nightwakings

Parasomnias

Sleep-disordered breathing

Day-time sleepiness

8.6 ± 3.8

2.4 ± 2.1

3.8 ± 1.3

6.1 ± 2.4

4.7 ± 1.6

8.9 ± 2.1

4 ± 1.7

14.1 ± 4.9

7.8 ± 2.2

1.4 ± 0.7

4 ± 1.3

5.4 ± 1.7

4 ± 1

8.9 ± 1.8

3.4 ± 0.8

14.7 ± 3.7

0.114

0.014

0.463

0.054

0.002

0.991

0.006

0.441

Results

The total sleep scores of the patients with FMF were significantly higher than the control group. Total sleep duration were similar between 2 groups. The comparison of subscale scores were given in table. Gender and age had no effect on total sleep scores in both groups. There was not a significant corelation between the total sleep score and disease duration, dose of colchicine, disease severity score, number of attacks in the last year, and serum C-reactive protein level in FMF patients. Besides, the patients with exercise-induced myalgia (n = 21) had significantly higher sleep scores than the patients without (n = 25) (54.8 ± 11.3 vs 46.3 ± 7.8, p = 0.008).

Conclusion

This is the first study investigating sleep patterns, sleep disturbances and possible factors that are associated with sleep disturbances among children with FMF. The results of this study suggested that exercise-induced myalgia might contribute to sleep disturbances in FMF as well as ongoing subclinical inflammation.

Disclosure of interest

None declared.

Authors’ Affiliations

(1)
Dokuz Eylül University Hospital, Izmir, Turkey

Copyright

© Makay et al.; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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