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  • Meeting abstract
  • Open Access

P02-033 - CAPS diagnosis and treatment in an Israeli family

  • 1,
  • 2, 3,
  • 1, 4 and
  • 5
Pediatric Rheumatology201311 (Suppl 1) :A140

  • Published:


  • Colchicine
  • Amyloidosis
  • Acute Phase Reactant
  • Pathogenic Variant
  • Mucosal Ulcer


Only one family in Israel, from Ethiopian Jewish origin has been diagnosed with the familial cold autoinflammatory syndrome phenotype of the cryopyrin associated periodic syndromes (CAPS)[1].

Case report

We confirmed the Muckle-Wells syndrome phenotype of CAPS by NLRP3 genetic testing in a three generation family of Turkish Jewish origin, previously diagnosed with familial Behcet disease due to the presence of mucosal ulcers in several family members with the finding of the HLA-B51 antigen in at least one family member. Eight family members including a deceased grandfather, 4 of his daughters and three grandchildren had brief episodes of fever and chills, accompanied by headache, myalgia, arthralgia, and an urticarial skin rash. Most family members had substantial hearing loss. None developed amyloidosis. Four family members tested for a NLRP3 pathogenic variant had the known NM_001243313.1:c.1043C>T, p.Thr348Met variant[2]. Following initiation of treatment with canakinumab (150 mg every 8 weeks) and colchicine for mucosal ulcers all disease symptoms resolved and acute phase reactants normalized except for persistent headaches in one grandchild and tinitus in another. The health-related quality of life of the treated grandchildren markedly improved.


NLRP3 genetic testing was instrumental in the diagnosis of CAPS in this family, particularly as some family members presented with atypical features suggestive of Behcet disease, which is much more common in Israel. Although CAPS is a rare disease, additional cases with other NLRP3 variants may exist in Israel.

Disclosure of interest

Y. Shinar: None Declared, G. Breuer: None Declared, A. Livneh Grant / Research Support from: Novartis, P. Hashkes Grant / Research Support from: Novartis, Consultant for: Novartis, Speaker bureau of: Novartis.

Authors’ Affiliations

Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, Israel
Rheumatology Unit, Shaare Zedek Medical Center, Israel
Hebrew University School of Medicine, Hebrew University, Jerusalem, Israel
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel


  1. Shalev SA, Sprecher E, Indelman M, Hujirat Y, Bergman R, Rottem M: A novel missense mutation in CIAS1 encoding the pyrin-like protein, cryopyrin, causes familial cold autoinflammatory syndrome in a family of ethiopian origin. Int Arch Allergy Immunol. 2007, 143: 190-3. 10.1159/000099311.View ArticlePubMedGoogle Scholar
  2. Dodé C, Le Dû N, Cuisset L: New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes. Am J Hum Genet. 2002, 70: 1498-506. 10.1086/340786.PubMed CentralView ArticlePubMedGoogle Scholar


© Shinar et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.