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Pulmonary thromboembolism in children with rheumatic diseases
© Vogler et al; licensee BioMed Central Ltd. 2012
Published: 13 July 2012
To demonstrate the clinical features and predisposing factors of pulmonary thrombotic events in children with rheumatic diseases.
Chart review, observational.
Age at Dx (yr)
Age at PTE
647 (nl <220)
4.7 (nl 3.7-5.5)
AT III (%)
105 (nl 77-132)
718 (nl 180-394)
Although antiphospholipid antibodies are common in SLE, pulmonary arterial thrombosis is rare. These 4 cases of SLE represent only 1.7% of 234 pediatric lupus patients seen at Emory University over 18 years. Pulmonary thromboemboli may mimic pleuritis with effusion or pneumonia. Besides antiphospholipid antibodies, which were present in only 2 of these patients, other associated findings include nephrotic syndrome, elevated D-dimers and elevated fibrinogen levels. Recognition of PTE in pediatric patients with rheumatic diseases and prompt anti-coagulation therapy is important and potentially life-saving.
Larry B. Vogler: None; Sheila Angeles-Han: None; Sampath Prahalad: None; Egla C. Rabinovich: None.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.