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Table 1

From: Pulmonary thromboembolism in children with rheumatic diseases

Pt/Gender

1/F

2/F

3/M

4/F

5/M

6/M

Dx

SLE

SLE

SLE

SLE

SSc

PAN

 

thrombocytopenia

nephritis (IV)

nephritis (V)

nephritis (IV)

PAH

CVA

Age at Dx (yr)

12.6

14.1

9.0

12.0

12.8

0.3

Age at PTE

15.2

14.8

16.8

12.6

16

6/4

Symptoms

leg pain

chest pain

chest pain

chest pain

chest pain

leg pain

  

dyspnea

dyspnea

dyspnea

dyspnea

 

DVT

+

-

-

-

-

+

Lupus AC

+

-

-

-

-

+/-

Anticardio AB

-

-

-

-

-

+

D-dimer (ng/ml)

647 (nl <220)

8770

1600

>10,000

n/a

>10,000

Albumin (g/dl)

4.7 (nl 3.7-5.5)

2.0

0.7

1.7

4.1

3.6

AT III (%)

105 (nl 77-132)

278

7/2

154

n/a

114

Fibrinogen (ng/dl)

718 (nl 180-394)

234

n/a

298

n/a

421

  1. [PAH pulmonary arterial hypertension, CVA: cerebral vascular accident, AT III: anti-thrombin III, N/A: not available] All patients were treated with heparin and improved. No patient had any other genetic risk factors predisposing to thrombophilia.