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Race is a risk factor for calcinosis in patients with JDM – early results from the CARRAnet registry study
© Hoeltzel et al; licensee BioMed Central Ltd. 2012
Published: 13 July 2012
Previously established risk factors for calcinosis include duration of disease and the length of time to treatment, suggesting early aggressive treatment may be important in preventing calcinosis. Race has also been suggested to be a risk factor, but this observation was thought to be secondary to delays in treatment. We utilized the CARRAnet registry to investigate potential risk factors for calcinosis.
Children with juvenile dermatomyositis (JDM) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry study were included in this analysis. Race and ethnicity were self-reported. Subjects with current or past calcinosis were identified, and bi-variable associations between clinical variables and calcinosis were evaluated by Chi-square test, Fisher exact test, two-sample t-test, or Wilcoxon Rank Sum test as appropriate. A multivariable stepwise logistic regression model was run that included variables that were significantly associated in the bi-variable analysis, defined by P<0.1. All statistical analyses were conducted using JMP Stats version 8.0 (SAS Institute, Cary, NC).
Analysis of calcinosis risk factors
Number (%) or Mean (+/-SD) with calcinosis
Bi-variable analysis (p-value)
Stepwise logistic regression analysis (OR [95%CI] p value
African American ancestry
5.8 [1.3, 24.8] 0.02*
Disease duration, yrs
Children with JDM of African American ancestry have increased odds of developing calcinosis, even after controlling for duration of disease and time to rheumatologic care. Male gender, negative ANA status, and disease duration were associated with calcinosis in bi-variable analysis, however, these variables were limited by incomplete data capture, which may have affected the results of the multi-variable regression model. Analysis of a larger more complete cohort is needed to confirm these observations.
Mark F. Hoeltzel: None; Mara L. Becker: None; Angela B. Robinson: None; Brian M. Feldman: None; Adam Huber: None; Ann M. Reed: None; Juvenile Myositis CARRA Subgroup: None; CARRAnet Investigators: None.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.