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  2. Overall outcomes of pediatric rheumatic diseases (RD) have improved due to treatment with biologic agents and methotrexate. For many children, this treatment often entails regular needle injections. Pain and f...

    Authors: Kari Sørensen, Helge Skirbekk, Gunnvald Kvarstein and Hilde Wøien
    Citation: Pediatric Rheumatology 2021 19:8
    Content type: Research article Published on:

  3. Shrinking lung syndrome (SLS), a rare complication of systemic lupus erythematosus (SLE) characterized by dyspnea, low lung volumes, and a restrictive pattern on pulmonary function tests (PFTs), has only been ...

    Authors: Chelsea DeCoste, Dimas Mateos-Corral and Bianca Lang
    Citation: Pediatric Rheumatology 2021 19:7
    Content type: Case Report Published on:

  4. Juvenile dermatomyositis (JDM) is a rare and sometimes fatal disease in children. The anti-NXP2 antibody is one of the most common antibodies and muscle ischaemia associated with NXP2 autoantibodies was a seve...

    Authors: Xinning Wang, Yuchuan Ding, Zhixuan Zhou, Jun Hou, Yingjie Xu and Jianguo Li
    Citation: Pediatric Rheumatology 2021 19:6
    Content type: Research article Published on:

  5. Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It is still debatable whether early intensive treatment is superior in terms of earlier achievement of remission. The aim of ...

    Authors: Ekaterina Alexeeva, Gerd Horneff, Tatyana Dvoryakovskaya, Rina Denisova, Irina Nikishina, Elena Zholobova, Viktor Malievskiy, Galina Santalova, Elena Stadler, Larisa Balykova, Yuriy Spivakovskiy, Ivan Kriulin, Alina Alshevskaya and Andrey Moskalev
    Citation: Pediatric Rheumatology 2021 19:5
    Content type: Research article Published on:

  6. Observations among Israeli pediatric rheumatologists reveal that pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US). This study is aimed to com...

    Authors: Nassem Ghantous, Merav Heshin-Bekenstein, Kimberly Dequattro, Yaniv Lakovsky, Amir Moshe Hendel, Nadav Rappoport, Yonatan Butbul Aviel, Irit Tirosh, Liora Harel, Pamela F. Weiss, Lianne Gensler, John Mackenzie and Gil Amarilyo
    Citation: Pediatric Rheumatology 2021 19:4
    Content type: Research article Published on:

  7. To characterize suicidality among youth with juvenile fibromyalgia syndrome (JFMS) receiving treatment from pediatric rheumatologists at a tertiary care center in order to determine the prevalence of suicidali...

    Authors: Sabrina Gmuca, Maitry Sonagra, Rui Xiao, Kimberly S. Miller, Nina H. Thomas, Jami F. Young, Pamela F. Weiss, David D. Sherry and Jeffrey S. Gerber
    Citation: Pediatric Rheumatology 2021 19:3
    Content type: Research article Published on:

  8. To summarize the characteristics of gastrointestinal (GI) perforation in anti-nuclear matrix protein 2 (NXP2) antibody-associated juvenile dermatomyositis (JDM).

    Authors: Yingjie Xu, Xiaolin Ma, Zhixuan Zhou, Jianguo Li, Jun Hou, Jia Zhu, Min Kang, Jianming Lai and Xiaohui Li
    Citation: Pediatric Rheumatology 2021 19:2
    Content type: Research article Published on:

  9. Type I interferonopathies are a group of rare autoimmune diseases characterised by excessive activation of type I interferon that leads to disturbances in immune function. Three prime repair exonuclease 1 (TRE...

    Authors: Shiyu Zhang, Jiaxing Song, Yuyan Yang, Huilei Miao, Lu Yang, Yuehua Liu, Xue Zhang, Yaping Liu and Tao Wang
    Citation: Pediatric Rheumatology 2021 19:1
    Content type: Research article Published on:

  11. Children with JIA may experience difficulty with health related quality of life (HRQOL). The Patient Reported Outcomes Measurement Information System (PROMIS) a patient related outcome (PRO) measure, covers HR...

    Authors: Yufan Yan, Karen L. Rychlik, Marc B. Rosenman and Michael L. Miller
    Citation: Pediatric Rheumatology 2020 18:92
    Content type: Research article Published on:

  12. Measuring the outcomes that matter to children and young people (CYP) with juvenile idiopathic arthritis (JIA), is a necessary precursor to patient-centred improvements in quality of clinical care. We present ...

    Authors: Laura E. Lunt, Stephanie Shoop-Worrall, Nicola Smith, Gavin Cleary, Janet McDonagh, Andrew D. Smith, Wendy Thomson and Flora McErlane
    Citation: Pediatric Rheumatology 2020 18:91
    Content type: Research article Published on:

  14. To examine critical interactions between juvenile idiopathic arthritis synovial fibroblasts (JFLS) and chondrocytes (Ch), and their role in bony overgrowth seen in patients with juvenile idiopathic arthritis (...

    Authors: Megan M. Simonds, Amanda R. Schlefman, Suzanne M. McCahan, Kathleen E. Sullivan, Carlos D. Rose and AnneMarie C. Brescia
    Citation: Pediatric Rheumatology 2020 18:89
    Content type: Research article Published on:

  15. We sought to evaluate racial disparities in disease outcomes among children with polyarticular juvenile idiopathic arthritis (JIA) during a treat-to-target (TTT) intervention with clinical decision support (CDS).

    Authors: Joyce C. Chang, Rui Xiao, Jon M. Burnham and Pamela F. Weiss
    Citation: Pediatric Rheumatology 2020 18:88
    Content type: Research article Published on:

  16. Concerns about the safety and efficacy of vaccines in patients with autoimmune diseases (AID) have led to contradictions and low vaccination coverage in this population, who are at a higher risk of infections,...

    Authors: Ingrid Herta Rotstein Grein, Natalia Balera Ferreira Pinto, Noortje Groot, Camila Bertini Martins, Aline Lobo, Nadia Emi Aikawa, Cassia Barbosa, Maria Teresa Terreri, Aline Coelho Moreira da Fraga, Sheila Knupp Feitosa de Oliveira, Flavio Sztajnbok, Luciana B. Paim Marques, Aline Garcia Islabão, Simone Appenzeller, Blanca Bica, Juliana de Oliveira Sato…
    Citation: Pediatric Rheumatology 2020 18:87
    Content type: Research article Published on:

  17. Though outcome differences between children and adults with immunoglobulin A vasculitis (IgAV) has been well documented, it remains unclear if disease features in pediatric IgAV patients vary with onset age. W...

    Authors: Chun-Hua Liao, Melody Tsai, Yao-Hsu Yang, Bor-Luen Chiang and Li-Chieh Wang
    Citation: Pediatric Rheumatology 2020 18:86
    Content type: Research article Published on:

  18. The use of telemedicine in pediatric rheumatology has been historically low. The current COVID 19 global pandemic has forced a paradigm shift with many centers rapidly adopting virtual visits to conduct care r...

    Authors: Susan Shenoi, Kristen Hayward, Megan L. Curran, Elizabeth Kessler, Jay J. Mehta, Meredith P. Riebschleger and Helen E. Foster
    Citation: Pediatric Rheumatology 2020 18:85
    Content type: Commentary Published on:

  19. Henoch–Schönlein purpura (HSP) is a systemic small-vessel vasculitis also named IgA vasculitis that commonly affects the gastrointestinal tract. The video capsule endoscopy (VCE) characteristics of pediatric H...

    Authors: Youhong Fang, Kerong Peng, Hong Zhao and Jie Chen
    Citation: Pediatric Rheumatology 2020 18:84
    Content type: Research article Published on:

    The Correction to this article has been published in Pediatric Rheumatology 2022 20:33

  23. Heme oxygenase-1 (HMOX1) catalyzes the metabolism of heme into carbon monoxide, ferrous iron, and biliverdin. Through biliverdin reductase, biliverdin becomes bilirubin. HMOX1-deficiency is a rare autosomal reces...

    Authors: Alice S. Chau, Bonnie L. Cole, Jason S. Debley, Kabita Nanda, Aaron B. I. Rosen, Michael J. Bamshad, Deborah A. Nickerson, Troy R. Torgerson and Eric J. Allenspach
    Citation: Pediatric Rheumatology 2020 18:80
    Content type: Case Report Published on:

    The Correction to this article has been published in Pediatric Rheumatology 2022 20:19

  24. We aimed to test if standardized point-of-care outcome monitoring and clinical decision support (CDS), as compared to standard care, improves disease activity and patient-reported pain in children with enthesi...

    Authors: Francesca Tirelli, Rui Xiao, Timothy G. Brandon, Jon M. Burnham, Joyce C. Chang and Pamela F. Weiss
    Citation: Pediatric Rheumatology 2020 18:79
    Content type: Research article Published on:

  26. Children presenting with musculoskeletal pain to pediatric rheumatology clinics are very heterogeneous and on a continuum from those with localized pain to total body pain. Many report intermittent, rather tha...

    Authors: David D. Sherry, Maitry Sonagra and Sabrina Gmuca
    Citation: Pediatric Rheumatology 2020 18:77
    Content type: Research article Published on:

  27. Kawasaki disease (KD) is the most common pediatric systemic vasculitides of unknown etiology. Recent clinical studies led to reappraisal of the usefulness of initial combination therapy of intravenous immunogl...

    Authors: Takashi Inoue, Shokei Murakami, Kenji Matsumoto and Akio Matsuda
    Citation: Pediatric Rheumatology 2020 18:76
    Content type: Research article Published on:

  28. Intraarticular corticosteroids (IACs) have been used to treat temporomandibular joint (TMJ) arthritis. However, prospective clinical studies with magnetic resonance imaging (MRI) scoring are lacking. The aim o...

    Authors: Paula Frid, Thomas A. Augdal, Tore A. Larheim, Josefine Halbig, Veronika Rypdal, Nils Thomas Songstad, Annika Rosén, Karin B. Tylleskär, Johanna Rykke Berstad, Berit Flatø, Peter Stoustrup, Karen Rosendahl, Eva Kirkhus and Ellen Nordal
    Citation: Pediatric Rheumatology 2020 18:75
    Content type: Research article Published on:

  29. Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels. Based on inherited complemen...

    Authors: Taha Al-Shaikhly, Kristen Hayward, Matthew L. Basiaga and Eric J. Allenspach
    Citation: Pediatric Rheumatology 2020 18:74
    Content type: Research article Published on:

  30. The European League Against Rheumatism (EULAR) Sjögren Syndrome Disease Activity Index (ESSDAI) has been utilized to assess Sjögren syndrome-related systemic involvement in adult patients. To date, however, th...

    Authors: Naomi Iwata, Minako Tomiita, Ichiro Kobayashi, Yusaburo Inoue, Yukiko Nonaka, Nami Okamoto, Hiroaki Umebayashi, Ryoki Hara, Yasuhiko Ito, Yasunori Sato and Masaaki Mori
    Citation: Pediatric Rheumatology 2020 18:73
    Content type: Research article Published on:

  31. Myhre syndrome is a genetic disorder caused by gain of function mutations in the SMAD Family Member 4 (SMAD4) gene, resulting in progressive, proliferative skin and organ fibrosis. Skin thickening and joint contr...

    Authors: Barbara Jensen, Rebecca James, Ying Hong, Ebun Omoyinmi, Clarissa Pilkington, Neil J. Sebire, Kevin J. Howell, Paul A. Brogan and Despina Eleftheriou
    Citation: Pediatric Rheumatology 2020 18:72
    Content type: Case Report Published on:

  32. There is a lack of awareness of paediatric rheumatic diseases (PRDs), among the public, and certain groups of healthcare professionals (HCPs), including general practitioners. To help improve international awa...

    Authors: Eve M. D. Smith, Sammy Ainsworth, Michael W. Beresford, Veerle Buys, Wendy Costello, Yona Egert, Helen E. Foster, Lovro Lamot, Berent J. Prakken, Christiaan Scott and Simon R. Stones
    Citation: Pediatric Rheumatology 2020 18:71
    Content type: Commentary Published on:

  33. Juvenile spondyloarthritis (JSpA) represents a group of inflammatory arthritides with several distinctive features (enthesitis, involvement of spine and sacroiliac joint, HLA-B27 association and development of...

    Authors: Achille Marino, Pamela F. Weiss, Timothy G. Brandon and Melissa A. Lerman
    Citation: Pediatric Rheumatology 2020 18:70
    Content type: Short Report Published on:

  34. A spectrum of rare noninflammatory disorders may present with arthropathy that arises from bony dysplasia, a thickened synovium, and noninflammatory effusion, leading to a constellation of clinical features th...

    Authors: Basil M. Fathalla, Elham Ahmed Elgabaly and Ahmad Abou Tayoun
    Citation: Pediatric Rheumatology 2020 18:69
    Content type: Case Report Published on:

  35. Temporomandibular joint (TMJ) arthritis and involvement is commonly seen in Juvenile Idiopathic Arthritis (JIA). Therapy includes conservative measures, but also includes intraarticular corticosteroid injectio...

    Authors: Michael Lypka, Karina Shah and Jordan Jones
    Citation: Pediatric Rheumatology 2020 18:68
    Content type: Research article Published on:

  36. Deficiency of the natural antagonist of interleukin-1 was first described in 2009 and so far 20 patients has been reported. In Brazil just two cases have been reported both carrying the same homozygous 15 bp d...

    Authors: Leonardo Oliveira Mendonça, Alice Grossi, Francesco Caroli, Robson Aguiar de Oliveira, Jorge Kalil, Fabio Fernandes Morato Castro, Alessandra Pontillo, Isabella Ceccherini, Myrthes Anna Maragna Toledo Barros and Marco Gattorno
    Citation: Pediatric Rheumatology 2020 18:67
    Content type: Review Published on:

  37. The purpose of this study was to identify reproductive health knowledge gaps and topics that concern adolescent and young adult (AYA) women with pediatric rheumatic diseases and their parents.

    Authors: Kristine Carandang, Veronica Mruk, Stacy P. Ardoin, Brittany Huynh, Megan E. B. Clowse, Elise D. Berlan and Cuoghi Edens
    Citation: Pediatric Rheumatology 2020 18:66
    Content type: Research article Published on:

  39. Methotrexate is the most commonly used disease-modifying antirheumatic drug recommended in the treatment of juvenile idiopathic arthritis. It can be administered orally or subcutaneously, the latter method is ...

    Authors: Justyna Roszkiewicz, Zbigniew Swacha and Elżbieta Smolewska
    Citation: Pediatric Rheumatology 2020 18:64
    Content type: Research article Published on:

  41. Kikuchi-Fujimoto disease (KFD) or necrotizing histiocytic lymphadenitis, was described separately by both Kikuchi and Fujimoto in Japan in the early 1970’s. Despite its rarity in the pediatric population, it i...

    Authors: Ashfaque Quadir, Ken Peacock, Peter Hsu, Davinder Singh-Grewal and Stephen Alexander
    Citation: Pediatric Rheumatology 2020 18:62
    Content type: Case Report Published on:

  42. For reasons poorly understood, and despite the availability of biological medications blocking IL-1 and IL-6 that have markedly improved overall disease control, children with Systemic Juvenile Idiopathic Arth...

    Authors: Scott W. Canna, Grant S. Schulert, Adriana de Jesus, Alex Pickering, Hermine Brunner, Massimo Gadina, Stewart Levine, Raphaela Goldbach-Mansky, Jonathan Boutelle, Rashmi Sinha, Fabrizio DeBenedetti and Alexei Grom
    Citation: Pediatric Rheumatology 2020 18(Suppl 1):53
    Content type: Meeting report Published on:

    This article is part of a Supplement: Volume 18 Supplement 1

  43. Kawasaki disease (KD) is an acute, self-limiting systemic vasculitis that predominately affects children. Neurological involvement is a known complication of KD, however, its association with KD severity remai...

    Authors: Xiaoliang Liu, Kaiyu Zhou, Yimin Hua, Mei Wu, Lei Liu, Shuran Shao and Chuan Wang
    Citation: Pediatric Rheumatology 2020 18:61
    Content type: Research article Published on:

  44. There is increasing concern about the emerging global non-communicable diseases (NCDs) burden. The focus has mainly been on NCDs in adults but it is important that MSK morbidity in both children and adults is ...

    Authors: Helen E. Foster, Christiaan Scott, Carl J. Tiderius and Matthew B. Dobbs
    Citation: Pediatric Rheumatology 2020 18:60
    Content type: Commentary Published on:

  45. Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity. As a long lasting chronic infla...

    Authors: Inmaculada Concepción Aranda-Valera, Iván Arias de la Rosa, Rosa Roldán-Molina, María del Carmen Ábalos-Aguilera, Carmen Torres-Granados, Alejandra Patiño-Trives, María Luque-Tevar, Alejandro Ibáñez-Costa, Rocío Guzmán-Ruiz, María del Mar Malagón, Alejandro Escudero-Contreras, Chary López-Pedrera, Eduardo Collantes-Estévez and Nuria Barbarroja
    Citation: Pediatric Rheumatology 2020 18:59
    Content type: Research article Published on:

  46. Systemic lupus erythematosus (SLE) is an autoimmune disease with various clinical manifestations involving multiple organ systems. Neuropsychiatric manifestations of SLE have been associated with increased mor...

    Authors: Alexandra Theisen, Paroma Bose, Christina Knight and Melissa Oliver
    Citation: Pediatric Rheumatology 2020 18:58
    Content type: Case Report Published on:

  47. Inflammatory arthritis in children with Down syndrome (DS) was first described in 1984 and is now termed Down syndrome-associated arthritis (DA). Studies have shown that DA is under-recognized with a 19-month ...

    Authors: Anna Nicek, Nasreen Talib, Daniel Lovell, Chelsey Smith, Mara L. Becker and Jordan T. Jones
    Citation: Pediatric Rheumatology 2020 18:57
    Content type: Research article Published on:

  48. Hyperferritinemic syndromes are systemic inflammatory disorders characterized by a dysfunctional immune response, which leads to excessive activation of the monocyte-macrophage system with hypercytokinemia and...

    Authors: Riccardo Papa, Valentina Natoli, Roberta Caorsi, Francesca Minoia, Marco Gattorno and Angelo Ravelli
    Citation: Pediatric Rheumatology 2020 18:56
    Content type: Case Report Published on:

  49. FBLIM1 gene has been recently demonstrated to be involved in the pathogenesis of bone sterile inflammation. The aim of the study is to evaluate the prevalence of FBLIM1 gene variants in a cohort of 80 Italian pat...

    Authors: Adamo Pio d’Adamo, Anna Monica Bianco, Giovanna Ferrara, Martina La Bianca, Antonella Insalaco, Alberto Tommasini, Manuela Pardeo, Marco Cattalini, Francesco La Torre, Martina Finetti, Clotilde Alizzi, Gabriele Simonini, Virginia Messia, Serena Pastore, Rolando Cimaz, Marco Gattorno…
    Citation: Pediatric Rheumatology 2020 18:55
    Content type: Research article Published on:

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ISSN: 1546-0096