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  1. Content type: Review

    Children and adolescents with Juvenile Idiopathic Arthritis (JIA) typically have reduced physical activity level and impaired aerobic and anaerobic exercise capacity when compared to their non-JIA counterparts...

    Authors: Andrea Coda, Dean Sculley, Derek Santos, Xavier Girones, Lucie Brosseau, Derek R. Smith, Joshua Burns, Keith Rome, Jane Munro and Davinder Singh-Grewal

    Citation: Pediatric Rheumatology 2017 15:40

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  2. Content type: Case report

    The etiology of Kawasaki disease (KD) remains unknown. However, many studies have suggested that specific genetic factors and/or some infectious agents underlie the onset of KD. Previous studies have suggested...

    Authors: Sayaka Fukuda, Shuichi Ito, Maya Fujiwara, Jun Abe, Nozomu Hanaoka, Tsuguto Fujimoto and Hiroshi Katsumori

    Citation: Pediatric Rheumatology 2017 15:39

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  3. Content type: Research article

    The purpose of the study was to evaluate the clinical and magnetic resonance imaging (MRI) outcome of cervical spine arthritis in children with juvenile idiopathic arthritis (JIA), who received anti-TNFα early...

    Authors: Damjana Ključevšek, Nina Emeršič, Nataša Toplak and Tadej Avčin

    Citation: Pediatric Rheumatology 2017 15:38

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  4. Content type: Research article

    Existing data on associations between maternal and early childhood exposures and juvenile idiopathic arthritis (JIA) risk is scant and inconsistent with previous studies showing potential role for prematurity,...

    Authors: Samantha W. Bell, Susan Shenoi, J. Lee Nelson, Parveen Bhatti and Beth A. Mueller

    Citation: Pediatric Rheumatology 2017 15:36

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  5. Content type: Review

    The Lyme arthritis is a common manifestation of infection with Borrelia burgdorferi spirochete. Despite its infectious background, the inflammation clinically and histopatologically resembles juvenile idiopathic ...

    Authors: Krzysztof Orczyk, Joanna Świdrowska-Jaros and Elżbieta Smolewska

    Citation: Pediatric Rheumatology 2017 15:35

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  6. Content type: Short report

    Advances in juvenile idiopathic arthritis (JIA) treatment is promoting free disease survival. Cardiovascular disease (CVD) may emerge as an important cause of morbidity and mortality. Pulse wave velocity (PWV)...

    Authors: Maria Mercedes Picarelli, Luiz Cláudio Danzmann, Lucas Kich Grun, Nevton Teixeira Rosa Júnior, Patrícia Lavandovsky, Fátima Theresinha Costa Rodrigues Guma, Renato T. Stein, Florência Barbé-Tuana and Marcus Herbert Jones

    Citation: Pediatric Rheumatology 2017 15:34

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  7. Content type: Review

    Behçet’s disease (BD) and Crohn’s disease (CD) are chronic immune-mediated, inflammatory disorders affecting many different systems (joints, skin, eyes, gastrointestinal and biliary tracts). Both disorders hav...

    Authors: Simona Valenti, Romina Gallizzi, Dominique De Vivo and Claudio Romano

    Citation: Pediatric Rheumatology 2017 15:33

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  8. Content type: Research article

    Kawasaki disease (KD) is a febrile childhood vasculitis of unknown etiology. The diagnosis is highly concerning as over a quarter of children who fail to receive timely treatment with intravenous immunoglobuli...

    Authors: Rachel Engelberg, Meghan Martin, Brian H. Wrotniak and Mark Daniel Hicar

    Citation: Pediatric Rheumatology 2017 15:32

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  9. Content type: Research article

    To characterize the existing national and multi-national registries and cohort studies in juvenile idiopathic arthritis (JIA) and identify differences as well as areas of potential future collaboration.

    Authors: Timothy Beukelman, Janneke Anink, Lillemor Berntson, Ciaran Duffy, Justine A. Ellis, Mia Glerup, Jaime Guzman, Gerd Horneff, Lianne Kearsley-Fleet, Ariane Klein, Jens Klotsche, Bo Magnusson, Kirsten Minden, Jane E. Munro, Martina Niewerth, Ellen Nordal…

    Citation: Pediatric Rheumatology 2017 15:31

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  10. Content type: Research article

    Herein we describe the history, design, and rationale of the new Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and present the characteristics of patients with juvenile idiopathic art...

    Authors: Timothy Beukelman, Yukiko Kimura, Norman T. Ilowite, Kelly Mieszkalski, Marc D. Natter, Grendel Burrell, Brian Best, Jason Jones and Laura E. Schanberg

    Citation: Pediatric Rheumatology 2017 15:30

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  11. Content type: Research article

    Delayed diagnosis of childhood Takayasu arteritis (TA) is common due to its atypical symptoms. The objective of the present study was to summarize the clinical features of childhood TA to raise awareness and i...

    Authors: Ye Feng, Xuemei Tang, Mingyue Liu, Juan Zhou, Xiaodong Zhao and Qiu Li

    Citation: Pediatric Rheumatology 2017 15:29

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  12. Content type: Review

    Granulomatosis with polyangiitis is an ANCA-associated systemic vasculitis with a low incidence in the pediatric population. Lung involvement is a common manifestation in children affected by granulomatosis wi...

    Authors: Giovanni Filocamo, Sofia Torreggiani, Carlo Agostoni and Susanna Esposito

    Citation: Pediatric Rheumatology 2017 15:28

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  13. Content type: Research article

    Although it is common clinical practice to treat children with Juvenile Idiopathic Arthritis (JIA) with functional appliances, the scientific evidence for this is limited. The aim of this study was to study th...

    Authors: Julia von Bremen, Kernt Köhler, Krystyna Siudak, Daniel Zahner and Sabine Ruf

    Citation: Pediatric Rheumatology 2017 15:27

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  14. Content type: Research article

    This study investigates gender differences in self-reports and between parent and child reports in Health-related Quality of Life (HRQOL), measured with disease-specific and generic instruments for chronic dis...

    Authors: Veronica Lundberg and Catharina Eriksson

    Citation: Pediatric Rheumatology 2017 15:26

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  15. Content type: Research article

    The course of JDM has improved substantially over the last 70 years with early and aggressive treatments. Yet it remains difficult to detect disease flares as symptoms may be mild; signs of rash and muscle wea...

    Authors: Rabheh Abdul-Aziz, Chack-Yung Yu, Brent Adler, Sharon Bout-Tabaku, Katherine E. Lintner, Melissa Moore-Clingenpeel and Charles H. Spencer

    Citation: Pediatric Rheumatology 2017 15:25

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  16. Content type: Research article

    The Assessment of Spondyloarthritis International Society (ASAS) definition for a ‘positive’ Magnetic Resonance Imaging (MRI) for sacroiliitis is well studied and validated in adults, but studies about the val...

    Authors: Nele Herregods, Joke Dehoorne, Filip Van den Bosch, Jacob Lester Jaremko, Joke Van Vlaenderen, Rik Joos, Xenofon Baraliakos, Gaëlle Varkas, Koenraad Verstraete, Dirk Elewaut and Lennart Jans

    Citation: Pediatric Rheumatology 2017 15:24

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  17. Content type: Regular article

    To assess the feasibility of studying the comparative effectiveness of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans (CTPs) for systemic Juvenile Idiopathic Arthr...

    Authors: Yukiko Kimura, Sriharsha Grevich, Timothy Beukelman, Esi Morgan, Peter A. Nigrovic, Kelly Mieszkalski, T Brent Graham, Maria Ibarra, Norman Ilowite, Marisa Klein-Gitelman, Karen Onel, Sampath Prahalad, Marilynn Punaro, Sarah Ringold, Dana Toib, Heather Van Mater…

    Citation: Pediatric Rheumatology 2017 15:23

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  18. Content type: Research article

    The aims of this study were to: (a) Identify tendon sheaths most commonly treated with steroid injections in a pediatric patient population with Juvenile Idiopathic Arthritis (JIA); (b) Describe technical aspe...

    Authors: Shannon E. Peters, Ronald M. Laxer, Bairbre L. Connolly and Dimitri A. Parra

    Citation: Pediatric Rheumatology 2017 15:22

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  19. Content type: Regular article

    BK virus (BKV) is a ubiquitous polyoma virus that lies dormant in the genitourinary tract once acquired in early childhood. In states of cellular immunodeficiency, the virus can reactivate to cause hemorrhagic...

    Authors: Nirupama Gupta, Cuong Q. Nguyen, Renee F. Modica, Melissa E. Elder and Eduardo H. Garin

    Citation: Pediatric Rheumatology 2017 15:21

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  20. Content type: Research article

    There are few studies on radiographic outcome after long-term disease duration in juvenile idiopathic arthritis (JIA). We wanted to evaluate 29-year radiographic outcome in hands/wrists and predictors of damag...

    Authors: Anne M. Selvaag, Eva Kirkhus, Lena Törnqvist, Vibke Lilleby, Hanne A. Aulie and Berit Flatø

    Citation: Pediatric Rheumatology 2017 15:20

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  21. Content type: Case report

    Systemic autoinflammatory diseases (SAIDs) represent a growing number of monogenic, polygenic or multifactorial disorders that are often difficult to diagnose.

    Authors: Helmut Wittkowski, Claas Hinze, Sigrid Häfner-Harms, Vinzenz Oji, Katja Masjosthusmann, Martina Monninger, Ulrike Grenzebach and Dirk Foell

    Citation: Pediatric Rheumatology 2017 15:19

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  22. Content type: Review

    Most outcome studies of rheumatic diseases report outcomes ascertained on a single occasion. While single assessments are sufficient for terminal or irreversible outcomes, they may not be sufficiently informat...

    Authors: Lily Siok Hoon Lim, Eleanor Pullenayegum, Rahim Moineddin, Dafna D Gladman, Earl D Silverman and Brian M Feldman

    Citation: Pediatric Rheumatology 2017 15:18

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  23. Content type: Short report

    Inflammatory bowel disease can develop in the context of some rheumatic diseases in childhood, including juvenile idiopathic arthritis (JIA). Inflammatory bowel disease (IBD) is frequently associated with othe...

    Authors: Boris Hügle, Fabian Speth and Johannes-Peter Haas

    Citation: Pediatric Rheumatology 2017 15:16

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  24. Content type: Research article

    In children with Henoch-Schonlein purpura nephritis (HSPN), the degree of proteinuria has been proven to be not only a sign of kidney damage, but also an accelerator of kidney disease progression. Nephrotic pr...

    Authors: Dan Feng, Wen-Yan Huang, Sheng Hao, Xiao-Ling Niu, Ping Wang, Ying Wu and Guang-Hua Zhu

    Citation: Pediatric Rheumatology 2017 15:15

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  25. Content type: Research article

    Systemic Lupus Erythematosus (SLE) is a serious multisystem autoimmune disease, which is more aggressive in children and people of African descent. In South Africa, pediatric SLE (pSLE) patients are at high ri...

    Authors: Laura B. Lewandowski, Melissa H. Watt, Laura E. Schanberg, Nathan M. Thielman and Christiaan Scott

    Citation: Pediatric Rheumatology 2017 15:14

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  26. Content type: Research article

    To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA).

    Authors: Maria Ekelund, Kristiina Aalto, Anders Fasth, Troels Herlin, Susan Nielsen, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Marek Zak and Lillemor Berntson

    Citation: Pediatric Rheumatology 2017 15:13

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  27. Content type: Research article

    The aim of the study was to determine whether polymorphisms in toll-like receptor 4 (TLR4) confer susceptibility to rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han...

    Authors: Yan Wang, Lianghui Chen, Fang Li, Meihua Bao, Jie Zeng, Ju Xiang, Huaiqing Luo, Jianming Li and Liang Tang

    Citation: Pediatric Rheumatology 2017 15:12

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  28. Content type: Short report

    Combination therapy with prednisone or etanercept may induce earlier and/or more improvement in disease activity in Disease Modifying Anti Rheumatic Drug (DMARD) naïve non-systemic Juvenile Idiopathic Arthriti...

    Authors: P. C. E. Hissink Muller, D. M. C. Brinkman, D. Schonenberg, Y. Koopman-Keemink, I. C. J. Brederije, W. P. Bekkering, T. W. Kuijpers, M. A. J. van Rossum, L. W. A. van Suijlekom-Smit, J. M. van den Berg, C. F. Allaart and R. ten Cate

    Citation: Pediatric Rheumatology 2017 15:11

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  29. Content type: Research article

    Rheumatic heart disease (RHD) is an autoimmune disease where cross reactive CD4+ T cells are involved in the pathogenesis of valvular damage. Human Leukocyte Antigen-G (HLA-G), an immunosuppressive molecule playi...

    Authors: Maheshkumar Poomarimuthu, Sivakumar Elango, Sambath Soundrapandian and Jayalakshmi Mariakuttikan

    Citation: Pediatric Rheumatology 2017 15:10

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  30. Content type: Research article

    The usefulness of musculoskeletal ultrasonography (MSUS) in paediatric population is limited by lack of reference values. One of such parameters is hip joint capsule thickness, postulated as an early measure f...

    Authors: Zbigniew Żuber, Aleksander Owczarek, Małgorzata Sobczyk, Agata Migas-Majoch, Dorota Turowska-Heydel, Agnieszka Sternal, Justyna Michalczak and Jerzy Chudek

    Citation: Pediatric Rheumatology 2017 15:8

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  31. Content type: Research article

    Paediatric rheumatology service in Sub-Sahara African is virtually not available as there is a shortage of paediatric rheumatologists and other rheumatology health professionals. We aim to describe the clinica...

    Authors: Babatunde Hakeem Olaosebikan, Olufemi Oladipo Adelowo, Barakat Adeola Animashaun and Richard Oluyinka Akintayo

    Citation: Pediatric Rheumatology 2017 15:7

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  32. Content type: Research article

    Pediatric rheumatic diseases are chronic illnesses that can cause considerable disease burden to children and their families. There is limited epidemiologic data on these diseases in East Africa. The aim of th...

    Authors: Angela Migowa, Inés Colmegna, Carol Hitchon, Eugene Were, Evelyn Ng’ang’a, Thomas Ngwiri, John Wachira, Sasha Bernatsky and Rosie Scuccimarri

    Citation: Pediatric Rheumatology 2017 15:4

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  33. Content type: Short report

    Oligoarticular juvenile idiopathic arthritis (oligoJIA), the most common chronic inflammatory arthritis of childhood, usually involves the knees and ankles. Severe oligoJIA monoarthritis presenting in a joint ...

    Authors: Natasha Lepore, Megan Cashin, Debra Bartley and Daniela Simona Ardelean

    Citation: Pediatric Rheumatology 2017 15:2

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  34. Content type: Research article

    Juvenile dermatomyositis (JDM) is the most common form of the idiopathic inflammatory myopathies in children. A subset of children have the rash of JDM without significant weakness, and the optimal treatments ...

    Authors: Susan Kim, Philip Kahn, Angela B. Robinson, Bianca Lang, Andrew Shulman, Edward. J. Oberle, Kenneth Schikler, Megan Lea Curran, Lilliana Barillas-Arias, Charles H. Spencer, Lisa G. Rider and Adam M. Huber

    Citation: Pediatric Rheumatology 2017 15:1

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  35. Content type: Research article

    Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim of this analysis was to investigat...

    Authors: Sara Verazza, Sergio Davì, Alessandro Consolaro, Francesca Bovis, Antonella Insalaco, Silvia Magni-Manzoni, Rebecca Nicolai, Denise Pires Marafon, Fabrizio De Benedetti, Valeria Gerloni, Irene Pontikaki, Francesca Rovelli, Rolando Cimaz, Achille Marino, Francesco Zulian, Giorgia Martini…

    Citation: Pediatric Rheumatology 2016 14:68

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  36. Content type: Research article

    The number of trained specialists world-wide is insufficient to serve all children with pediatric rheumatologic disorders, even in the countries with robust medical resources. We evaluated the potential of dia...

    Authors: Michael M. Segal, Balu Athreya, Mary Beth F. Son, Irit Tirosh, Jonathan S. Hausmann, Elizabeth Y. N. Ang, David Zurakowski, Lynn K. Feldman and Robert P. Sundel

    Citation: Pediatric Rheumatology 2016 14:67

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  37. Content type: Research article

    Fatigue is common in patients with JIA and affects daily life negatively. We assessed the presence and severity of fatigue in patients with JIA, including factors presumed associated with fatigue (e.g., diseas...

    Authors: Wineke Armbrust, Otto H. T. M. Lelieveld, Jolanda Tuinstra, Nico M. Wulffraat, G. J. F. Joyce Bos, Jeannette Cappon, Marion A. J. van Rossum, Pieter J. J. Sauer and Mariët Hagedoorn

    Citation: Pediatric Rheumatology 2016 14:65

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  38. Content type: Research article

    Dystrophic calcifications may occur in patients with J uvenile Idiopathic Inflammatory Myopathy (JIIM) as well as other connective tissue and metabolic diseases, but a reliable method of measuring the volume o...

    Authors: Maria Ibarra, Cynthia Rigsby, Gabrielle A. Morgan, Christina L. Sammet, Chiang-Ching Huang, Dong Xu, Ira N. Targoff and Lauren M. Pachman

    Citation: Pediatric Rheumatology 2016 14:64

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  39. Content type: Case Report

    The pathophysiological origin of juvenile idiopathic arthritis (JIA) is largely unknown. However, individuals with presumably pathogenic mutations in FAMIN have been reported, associating this gene with a rare su...

    Authors: Tilmann Kallinich, Anne Thorwarth, Sae-Lim von Stuckrad, Angela Rösen-Wolff, Hella Luksch, Patrick Hundsdoerfer, Kirsten Minden and Peter Krawitz

    Citation: Pediatric Rheumatology 2016 14:63

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  40. Content type: Research article

    Juvenile idiopathic arthritis (JIA) is a systemic chronic inflammatory disease. Studies using tissue Doppler imaging (TDI) for the evaluation of cardiac functions of children with JIA are limited. Thus, this s...

    Authors: Azza Z. El Eraky, Nesrin M. Handoka, Mona Sayed Ghaly, Samah Ismail Nasef, Nahed A. Eldahshan, Ahmed M. Ibrahim and Sherein Shalaby

    Citation: Pediatric Rheumatology 2016 14:62

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  41. Content type: Research article

    The purpose of the study is to determine levels of total cholesterol (TC), low-density, and high-density lipoprotein fractions of cholesterol (LDLc and HDLc), in patients with juvenile idiopathic arthritis (JI...

    Authors: Anna-Helene Bohr, Freddy Karup Pedersen, Claus Henrik Nielsen and Klaus Gottlob Müller

    Citation: Pediatric Rheumatology 2016 14:61

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  42. Content type: Research article

    Juvenile dermatomyositis (JDM) is a rare idiopathic inflammatory childhood myopathy of uncertain aetiology. The demographic and clinical presentation of JDM may differ by race and geographic regions. Few studi...

    Authors: Lawrence Owino Okong’o, Monika Esser, Jo Wilmshurst and Christiaan Scott

    Citation: Pediatric Rheumatology 2016 14:60

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