Articles

Methotrexate-induced nausea in the treatment of juvenile idiopathic arthritis

Methotrexate is the most commonly used disease modifying antirheumatic drug in the treatment of juvenile idiopathic arthritis and can be effective in controlling disease in many patients.

Authors: Sonja Falvey, Lauren Shipman, Norman Ilowite and Timothy Beukelman

Predictors of the response to etanercept in patients with juvenile idiopathic arthritis without systemic manifestations within 12 months: results of an open-label, prospective study conducted at the National Scientific and Practical Center of Children's Health, Russia

The aim of this study was to investigate the efficacy of etanercept treatment and to identify predictors of response to therapy within 12 months in patients with juvenile idiopathic arthritis (JIA) without sys...

Authors: Ekaterina I. Alexeeva, Leyla S. Namazova-Baranova, Tatyana M. Bzarova, Saniya I. Valieva, Rina V. Denisova, Tatyana V. Sleptsova, Kseniya B. Isaeva, Alexandra M. Chomahidze, Nikolay I. Taibulatov, Anna N. Fetisova, Anna V. Karaseva and Alexandr A. Baranov

Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America

The prognosis of children with juvenile dermatomyositis (JDM) has improved remarkably since the 1960’s with the use of corticosteroid and immunosuppressive therapy. Yet there remain a minority of children who ...

Authors: CH Spencer, K Rouster-Stevens, H Gewanter, G Syverson, R Modica, K Schmidt, H Emery, C Wallace, S Grevich, K Nanda, YD Zhao, S Shenoi, S Tarvin, S Hong, C Lindsley, JE Weiss…

Transitional care for rheumatic conditions in Europe: current clinical practice and available resources

To assess European pediatric rheumatology providers’ current clinical practices and resources used in the transition from child-centered to adult-oriented care.

Authors: Daniel Clemente, Leticia Leon, Helen Foster, Loreto Carmona and Kirsten Minden

Design and implementation of a decision aid for juvenile idiopathic arthritis medication choices

Randomized trials have demonstrated the efficacy of patient decision aids to facilitate shared decision making in clinical situations with multiple medically reasonable options for treatment. However, little i...

Authors: William B. Brinkman, Ellen A. Lipstein, Janalee Taylor, Pamela J. Schoettker, Katherine Naylor, Karla Jones, Sheetal S. Vora, Catherine C. Mims, Elizabeth Roth-Wojcicki, Beth Gottlieb, Nancy Griffin, Carole Lannon and Esi Morgan

Challenges in transitioning adolescents and young adults with rheumatologic diseases to adult Care in a Developing Country - the Brazilian experience

Transition guidelines and recommendations for developing countries are limited and best transition practices in young patients with chronic medical conditions have been poorly examined. This study evaluates tr...

Authors: Catherine Gusman Anelli, Ana Luiza Mendes Amorim, Fabiane Mitie Osaku, Maria Teresa Terreri, Claudio Arnaldo Len and Andreas Reiff

Proceedings of the 23^rd Paediatric Rheumatology European Society Congress: part two

Authors: Olga Lomakina, Ekaterina Alekseeva, Sania Valieva, Tatiana Bzarova, Irina Nikishina, Elena Zholobova, Svetlana Rodionovskaya, Maria Kaleda, Yasuo Nakagishi, Masaki Shimizu, Mao Mizuta, Akihiro Yachie, Yuko Sugita, Nami Okamoto, Kousuke Shabana, Takuji Murata…

Proceedings of the 23^rd Paediatric Rheumatology European Society Congress: part three

Authors: Riccardo Papa, Alessandro Consolaro, Francesca Minoia, Roberta Caorsi, Gianmichele Magnano, Marco Gattorno, Angelo Ravelli, Paolo Picco, Roberto Pillon, Denise Pires Marafon, Lidia Meli, Claudia Bracaglia, Andrea Taddio, Fabrizio De Benedetti, Enes Turan, Sara Sebnem Kilic…

Proceedings of the 23^rd Paediatric Rheumatology European Society Congress: part one

Authors: F. De Benedetti, J. Anton, M. Gattorno, H. Lachmann, I. Kone-Paut, S. Ozen, J. Frenkel, A. Simon, A. Zeft, E. Ben-Chetrit, H. M. Hoffman, Y. Joubert, K. Lheritier, A. Speziale, J. Guido, Roberta Caorsi…

Early feeding and risk of Juvenile idiopathic arthritis: a case control study in a prospective birth cohort

Juvenile idiopathic arthritis (JIA) is considered to be an autoimmune disease, but the etiology is unknown. We decided to study the influence of early nutrition on later development of JIA.

Authors: Erik Kindgren, Mats Fredrikson and Johnny Ludvigsson

Education and employment in patients with juvenile idiopathic arthritis – a standardized comparison to the German general population

Although several studies show that JIA-patients have significantly lower employment rates than the general population, the research on educational and occupational attainments in patients with juvenile idiopat...

Authors: Jenny Schlichtiger, Johannes-Peter Haas, Swaantje Barth, Betty Bisdorff, Lisa Hager, Hartmut Michels, Boris Hügle and Katja Radon

Endothelial progenitor cell number is not decreased in 34 children with Juvenile Dermatomyositis: a pilot study

A pilot study to determine endothelial progenitor cells (EPC) number in children with Juvenile Dermatomyositis (JDM).

Authors: Dong Xu, Akadia Kacha-Ochana, Gabrielle A. Morgan, Chiang-Ching Huang and Lauren M. Pachman

Access to pediatric rheumatology care for Juvenile Idiopathic Arthritis in the United Arab Emirates

This study looks at access to care for Juvenile Idiopathic Arthritis through pediatric rheumatology in the UAE, as an example of multi-ethnic society.

Authors: Khulood Khawaja and Mustafa Al-Maini

Harnessing interactive technologies to improve health outcomes in juvenile idiopathic arthritis

Children and adolescents with Juvenile Idiopathic Arthritis (JIA) typically have reduced physical activity level and impaired aerobic and anaerobic exercise capacity when compared to their non-JIA counterparts...

Authors: Andrea Coda, Dean Sculley, Derek Santos, Xavier Girones, Lucie Brosseau, Derek R. Smith, Joshua Burns, Keith Rome, Jane Munro and Davinder Singh-Grewal

Simultaneous development of Kawasaki disease following acute human adenovirus infection in monozygotic twins: A case report

The etiology of Kawasaki disease (KD) remains unknown. However, many studies have suggested that specific genetic factors and/or some infectious agents underlie the onset of KD. Previous studies have suggested...

Authors: Sayaka Fukuda, Shuichi Ito, Maya Fujiwara, Jun Abe, Nozomu Hanaoka, Tsuguto Fujimoto and Hiroshi Katsumori

Clinical and MRI outcome of cervical spine lesions in children with juvenile idiopathic arthritis treated with anti-TNFα drugs early in disease course

The purpose of the study was to evaluate the clinical and magnetic resonance imaging (MRI) outcome of cervical spine arthritis in children with juvenile idiopathic arthritis (JIA), who received anti-TNFα early...

Authors: Damjana Ključevšek, Nina Emeršič, Nataša Toplak and Tadej Avčin

Juvenile idiopathic arthritis in relation to perinatal and maternal characteristics: a case control study

Existing data on associations between maternal and early childhood exposures and juvenile idiopathic arthritis (JIA) risk is scant and inconsistent with previous studies showing potential role for prematurity,...

Authors: Samantha W. Bell, Susan Shenoi, J. Lee Nelson, Parveen Bhatti and Beth A. Mueller

When a patient suspected with juvenile idiopathic arthritis turns out to be diagnosed with an infectious disease – a review of Lyme arthritis in children

The Lyme arthritis is a common manifestation of infection with Borrelia burgdorferi spirochete. Despite its infectious background, the inflammation clinically and histopatologically resembles juvenile idiopathic ...

Authors: Krzysztof Orczyk, Joanna Świdrowska-Jaros and Elżbieta Smolewska

Arterial stiffness by oscillometric device and telomere lenght in juvenile idiopathic artrhitis with no cardiovascular risk factors: a cross-sectional study

Advances in juvenile idiopathic arthritis (JIA) treatment is promoting free disease survival. Cardiovascular disease (CVD) may emerge as an important cause of morbidity and mortality. Pulse wave velocity (PWV)...

Authors: Maria Mercedes Picarelli, Luiz Cláudio Danzmann, Lucas Kich Grun, Nevton Teixeira Rosa Júnior, Patrícia Lavandovsky, Fátima Theresinha Costa Rodrigues Guma, Renato T. Stein, Florência Barbé-Tuana and Marcus Herbert Jones

Intestinal Behçet and Crohn’s disease: two sides of the same coin

Behçet’s disease (BD) and Crohn’s disease (CD) are chronic immune-mediated, inflammatory disorders affecting many different systems (joints, skin, eyes, gastrointestinal and biliary tracts). Both disorders hav...

Authors: Simona Valenti, Romina Gallizzi, Dominique De Vivo and Claudio Romano

Observational study of Interleukin-21 (IL-21) does not distinguish Kawasaki disease from other causes of fever in children

Kawasaki disease (KD) is a febrile childhood vasculitis of unknown etiology. The diagnosis is highly concerning as over a quarter of children who fail to receive timely treatment with intravenous immunoglobuli...

Authors: Rachel Engelberg, Meghan Martin, Brian H. Wrotniak and Mark Daniel Hicar

A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities

To characterize the existing national and multi-national registries and cohort studies in juvenile idiopathic arthritis (JIA) and identify differences as well as areas of potential future collaboration.

Authors: Timothy Beukelman, Janneke Anink, Lillemor Berntson, Ciaran Duffy, Justine A. Ellis, Mia Glerup, Jaime Guzman, Gerd Horneff, Lianne Kearsley-Fleet, Ariane Klein, Jens Klotsche, Bo Magnusson, Kirsten Minden, Jane E. Munro, Martina Niewerth, Ellen Nordal…

The new Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry: design, rationale, and characteristics of patients enrolled in the first 12 months

Herein we describe the history, design, and rationale of the new Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and present the characteristics of patients with juvenile idiopathic art...

Authors: Timothy Beukelman, Yukiko Kimura, Norman T. Ilowite, Kelly Mieszkalski, Marc D. Natter, Grendel Burrell, Brian Best, Jason Jones and Laura E. Schanberg

Clinical study of children with Takayasu arteritis: a retrospective study from a single center in China

Delayed diagnosis of childhood Takayasu arteritis (TA) is common due to its atypical symptoms. The objective of the present study was to summarize the clinical features of childhood TA to raise awareness and i...

Authors: Ye Feng, Xuemei Tang, Mingyue Liu, Juan Zhou, Xiaodong Zhao and Qiu Li

Lung involvement in childhood onset granulomatosis with polyangiitis

Granulomatosis with polyangiitis is an ANCA-associated systemic vasculitis with a low incidence in the pediatric population. Lung involvement is a common manifestation in children affected by granulomatosis wi...

Authors: Giovanni Filocamo, Sofia Torreggiani, Carlo Agostoni and Susanna Esposito

Histologic effects of mandibular protrusion splints in antigen-induced TMJ arthritis in rabbits

Although it is common clinical practice to treat children with Juvenile Idiopathic Arthritis (JIA) with functional appliances, the scientific evidence for this is limited. The aim of this study was to study th...

Authors: Julia von Bremen, Kernt Köhler, Krystyna Siudak, Daniel Zahner and Sabine Ruf

Health-related quality of life among Swedish children with Juvenile Idiopathic Arthritis: parent–child discrepancies, gender differences and comparison with a European cohort

This study investigates gender differences in self-reports and between parent and child reports in Health-related Quality of Life (HRQOL), measured with disease-specific and generic instruments for chronic dis...

Authors: Veronica Lundberg and Catharina Eriksson

Muscle MRI at the time of questionable disease flares in Juvenile Dermatomyositis (JDM)

The course of JDM has improved substantially over the last 70 years with early and aggressive treatments. Yet it remains difficult to detect disease flares as symptoms may be mild; signs of rash and muscle wea...

Authors: Rabheh Abdul-Aziz, Chack-Yung Yu, Brent Adler, Sharon Bout-Tabaku, Katherine E. Lintner, Melissa Moore-Clingenpeel and Charles H. Spencer

ASAS definition for sacroiliitis on MRI in SpA: applicable to children?

The Assessment of Spondyloarthritis International Society (ASAS) definition for a ‘positive’ Magnetic Resonance Imaging (MRI) for sacroiliitis is well studied and validated in adults, but studies about the val...

Authors: Nele Herregods, Joke Dehoorne, Filip Van den Bosch, Jacob Lester Jaremko, Joke Van Vlaenderen, Rik Joos, Xenofon Baraliakos, Gaëlle Varkas, Koenraad Verstraete, Dirk Elewaut and Lennart Jans

Pilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic Juvenile Idiopathic Arthritis Consensus Treatment Plans

To assess the feasibility of studying the comparative effectiveness of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans (CTPs) for systemic Juvenile Idiopathic Arthr...

Authors: Yukiko Kimura, Sriharsha Grevich, Timothy Beukelman, Esi Morgan, Peter A. Nigrovic, Kelly Mieszkalski, T Brent Graham, Maria Ibarra, Norman Ilowite, Marisa Klein-Gitelman, Karen Onel, Sampath Prahalad, Marilynn Punaro, Sarah Ringold, Dana Toib, Heather Van Mater…

Ultrasound-guided steroid tendon sheath injections in juvenile idiopathic arthritis: a 10-year single-center retrospective study

The aims of this study were to: (a) Identify tendon sheaths most commonly treated with steroid injections in a pediatric patient population with Juvenile Idiopathic Arthritis (JIA); (b) Describe technical aspe...

Authors: Shannon E. Peters, Ronald M. Laxer, Bairbre L. Connolly and Dimitri A. Parra

BK viruria and viremia in children with systemic lupus erythematosus

BK virus (BKV) is a ubiquitous polyoma virus that lies dormant in the genitourinary tract once acquired in early childhood. In states of cellular immunodeficiency, the virus can reactivate to cause hemorrhagic...

Authors: Nirupama Gupta, Cuong Q. Nguyen, Renee F. Modica, Melissa E. Elder and Eduardo H. Garin

Radiographic damage in hands and wrists of patients with juvenile idiopathic arthritis after 29 years of disease duration

There are few studies on radiographic outcome after long-term disease duration in juvenile idiopathic arthritis (JIA). We wanted to evaluate 29-year radiographic outcome in hands/wrists and predictors of damag...

Authors: Anne M. Selvaag, Eva Kirkhus, Lena Törnqvist, Vibke Lilleby, Hanne A. Aulie and Berit Flatø

Munchausen by proxy syndrome mimicking systemic autoinflammatory disease: case report and review of the literature

Systemic autoinflammatory diseases (SAIDs) represent a growing number of monogenic, polygenic or multifactorial disorders that are often difficult to diagnose.

Authors: Helmut Wittkowski, Claas Hinze, Sigrid Häfner-Harms, Vinzenz Oji, Katja Masjosthusmann, Martina Monninger, Ulrike Grenzebach and Dirk Foell

Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients

Most outcome studies of rheumatic diseases report outcomes ascertained on a single occasion. While single assessments are sufficient for terminal or irreversible outcomes, they may not be sufficiently informat...

Authors: Lily Siok Hoon Lim, Eleanor Pullenayegum, Rahim Moineddin, Dafna D Gladman, Earl D Silverman and Brian M Feldman

Predictors for intravenous immunoglobulin resistance and coronary artery lesions in Kawasaki disease

To assess the predictors for intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) in Kawasaki disease (KD).

Authors: Tian Xie, Ying Wang, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang and Fangqi Gong

Inflammatory bowel disease following anti-interleukin-1-treatment in systemic juvenile idiopathic arthritis

Inflammatory bowel disease can develop in the context of some rheumatic diseases in childhood, including juvenile idiopathic arthritis (JIA). Inflammatory bowel disease (IBD) is frequently associated with othe...

Authors: Boris Hügle, Fabian Speth and Johannes-Peter Haas

A single-center analysis of Henoch-Schonlein purpura nephritis with nephrotic proteinuria in children

In children with Henoch-Schonlein purpura nephritis (HSPN), the degree of proteinuria has been proven to be not only a sign of kidney damage, but also an accelerator of kidney disease progression. Nephrotic pr...

Authors: Dan Feng, Wen-Yan Huang, Sheng Hao, Xiao-Ling Niu, Ping Wang, Ying Wu and Guang-Hua Zhu

Missed opportunities for timely diagnosis of pediatric lupus in South Africa: a qualitative study

Systemic Lupus Erythematosus (SLE) is a serious multisystem autoimmune disease, which is more aggressive in children and people of African descent. In South Africa, pediatric SLE (pSLE) patients are at high ri...

Authors: Laura B. Lewandowski, Melissa H. Watt, Laura E. Schanberg, Nathan M. Thielman and Christiaan Scott

Psoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up study

To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA).

Authors: Maria Ekelund, Kristiina Aalto, Anders Fasth, Troels Herlin, Susan Nielsen, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Marek Zak and Lillemor Berntson

TLR4 rs41426344 increases susceptibility of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population

The aim of the study was to determine whether polymorphisms in toll-like receptor 4 (TLR4) confer susceptibility to rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han...

Authors: Yan Wang, Lianghui Chen, Fang Li, Meihua Bao, Jie Zeng, Ju Xiang, Huaiqing Luo, Jianming Li and Liang Tang

A comparison of three treatment strategies in recent onset non-systemic Juvenile Idiopathic Arthritis: initial 3-months results of the BeSt for Kids-study

Combination therapy with prednisone or etanercept may induce earlier and/or more improvement in disease activity in Disease Modifying Anti Rheumatic Drug (DMARD) naïve non-systemic Juvenile Idiopathic Arthriti...

Authors: P. C. E. Hissink Muller, D. M. C. Brinkman, D. Schonenberg, Y. Koopman-Keemink, I. C. J. Brederije, W. P. Bekkering, T. W. Kuijpers, M. A. J. van Rossum, L. W. A. van Suijlekom-Smit, J. M. van den Berg, C. F. Allaart and R. ten Cate

“HLA-G 3′UTR gene polymorphisms and rheumatic heart disease: a familial study among South Indian population”

Rheumatic heart disease (RHD) is an autoimmune disease where cross reactive CD4⁺ T cells are involved in the pathogenesis of valvular damage. Human Leukocyte Antigen-G (HLA-G), an immunosuppressive molecule playi...

Authors: Maheshkumar Poomarimuthu, Sivakumar Elango, Sambath Soundrapandian and Jayalakshmi Mariakuttikan

Fecal calprotectin in juvenile idiopathic arthritis patients related to drug use

Patients with juvenile idiopathic arthritis (JIA) on non-steroidal anti- inflammatory drugs (NSAIDs) may experience abdominal pain. In adults, NSAID use has been linked to an increase in fecal calprotectin (FC...

Authors: Kristiina Aalto, Pekka Lahdenne and Kaija-Leena Kolho

Establishing percentile charts for hip joint capsule and synovial cavity thickness in apparently healthy children

The usefulness of musculoskeletal ultrasonography (MSUS) in paediatric population is limited by lack of reference values. One of such parameters is hip joint capsule thickness, postulated as an early measure f...

Authors: Zbigniew Żuber, Aleksander Owczarek, Małgorzata Sobczyk, Agata Migas-Majoch, Dorota Turowska-Heydel, Agnieszka Sternal, Justyna Michalczak and Jerzy Chudek

Spectrum of paediatric rheumatic diseases in Nigeria

Paediatric rheumatology service in Sub-Sahara African is virtually not available as there is a shortage of paediatric rheumatologists and other rheumatology health professionals. We aim to describe the clinica...

Authors: Babatunde Hakeem Olaosebikan, Olufemi Oladipo Adelowo, Barakat Adeola Animashaun and Richard Oluyinka Akintayo

A systematic review of psychosocial therapies for children with rheumatic diseases

To assess the quality of evidence for the effects of psychosocial therapies on pain and function in children with rheumatic diseases.

Authors: Ezra M. Cohen, Alessio Morley-Fletcher, Darshan H. Mehta and Yvonne C. Lee

Macrophage Activation Syndrome: different mechanisms leading to a one clinical syndrome

Macrophage activation syndrome (MAS) is a severe complication of rheumatic disease in childhood, particularly in systemic Juvenile Idiopathic Arthritis (sJIA). It is characterize by an uncontrolled activation ...

Authors: Claudia Bracaglia, Giusi Prencipe and Fabrizio De Benedetti

The spectrum of rheumatic in-patient diagnoses at a pediatric hospital in Kenya

Pediatric rheumatic diseases are chronic illnesses that can cause considerable disease burden to children and their families. There is limited epidemiologic data on these diseases in East Africa. The aim of th...

Authors: Angela Migowa, Inés Colmegna, Carol Hitchon, Eugene Were, Evelyn Ng’ang’a, Thomas Ngwiri, John Wachira, Sasha Bernatsky and Rosie Scuccimarri

Endothelial function in children with a history of henoch schonlein purpura

Although Henoch-Schonlein purpura (HSP) is the most common form of systemic vasculitis in children, the long term effect of HSP on endothelial function is still not clear. The aim of our study was to evaluate ...

Authors: Yonatan Butbul Aviel, Lotem Dafna, Giora Pilar and Riva Brik