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  1. Authors: Timothy Hahn, Carrie Daymont, Timothy Beukelman, Brandt Groh, Kimberly Hays, Catherine April Bingham and Lisabeth Scalzi
    Citation: Pediatric Rheumatology 2022 20:116

    The original article was published in Pediatric Rheumatology 2022 20:107

  2. Incomplete Kawasaki disease (IKD) initially presenting as retropharyngeal abnormality is very rare and is prone to misdiagnosis and missed diagnosis, often leading to poor prognosis. Most patients were misdiag...

    Authors: Yong-chao Chen, Hong-guang Pan, De-sheng Jia, Hao-cheng Wang, Lan Li and Yi-shu Teng
    Citation: Pediatric Rheumatology 2022 20:115
  3. Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We perfo...

    Authors: Elisabet Berthold, Alma Dahlberg, Anna Jöud, Helena Tydén, Bengt Månsson, Fredrik Kahn and Robin Kahn
    Citation: Pediatric Rheumatology 2022 20:114
  4. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) to compare treatment initiation strategies for systemic juvenile idiopathic arthritis (sJIA). First...

    Authors: Timothy Beukelman, George Tomlinson, Peter A. Nigrovic, Anne Dennos, Vincent Del Gaizo, Marian Jelinek, Mary Ellen Riordan, Laura E. Schanberg, Shalini Mohan, Erin Pfeifer and Yukiko Kimura
    Citation: Pediatric Rheumatology 2022 20:113
  5. Multisystem inflammatory syndrome in children (MIS-C) is a new syndrome with some clinical manifestations similar to Kawasaki disease (KD), which is difficult to distinguish.

    Authors: Tong Tong, Xuefeng Yao, Zhe Lin, Yijing Tao, Jiawen Xu, Xiao Xu, Zhihao Fang, Zhimin Geng, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang, Yujia Wang and Fangqi Gong
    Citation: Pediatric Rheumatology 2022 20:112
  6. The most severe complication associated with giant coronary aneurysm in children with Kawasaki disease is ischemic cardiomyopathy (ICM) caused by thrombosis. Addition of tissue plasminogen activator, Alteplase...

    Authors: Yanqiu Chu, Yunming Xu, Ce Wang, Xiaona Yu, Quanmei Ma and Hong Wang
    Citation: Pediatric Rheumatology 2022 20:111
  7. Since the onset of the recent COVID-19 pandemic, there have been growing concerns regarding multisystem inflammatory syndrome in children (MIS-C). This study aims to describe the clinico-epidemiological profil...

    Authors: Angela Migowa, Pauline Samia, Sean del Rossi, Oliver Ombeva Malande, Jasmit Shah, Chemutai Kenei, Joy Ayaya, Daisy Jeruto, Laura Oyiengo and Laura Lewandowski
    Citation: Pediatric Rheumatology 2022 20:110
  8. Biologic disease-modifying antirheumatic drugs (bDMARDs) have changed the treatment of juvenile idiopathic arthritis (JIA) patients notably, as bDMARDs enable substantially more patients to achieve remission. ...

    Authors: Job Gieling, Bart van den Bemt, Esther Hoppenreijs and Ellen Schatorjé
    Citation: Pediatric Rheumatology 2022 20:109
  9. Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoinflammatory bone disorder with predominantly paediatric onset. Children present with multifocal osteolytic lesions accompanied by bone pain and soft...

    Authors: Dita Cebecauerová, Hana Malcová, Veronika Koukolská, Zuzana Kvíčalová, Ondřej Souček, Lukáš Wagenknecht, Jiří Bronský, Zdeněk Šumník, Martin Kynčl, Marek Cebecauer and Rudolf Horváth
    Citation: Pediatric Rheumatology 2022 20:108
  10. Children with juvenile idiopathic arthritis (JIA) who achieve a drug free remission often experience a flare of their disease requiring either intraarticular steroids (IAS) or systemic treatment with disease m...

    Authors: Timothy Hahn, Carrie Daymont, Timothy Beukelman, Brandt Groh, Kimberly Hays, Catherine April Bingham and Lisabeth Scalzi
    Citation: Pediatric Rheumatology 2022 20:107

    The Publisher Correction to this article has been published in Pediatric Rheumatology 2022 20:116

  11. Autoinflammatory diseases are rare disorders of the innate immune system characterized by fever and other signs of inflammation. A feared complication of autoinflammatory diseases is the development of AA amyl...

    Authors: G. E. Legger, C. W. E. Dermer, A. F. Brunger, P. L. A. van Daele and H. L. A. Nienhuis
    Citation: Pediatric Rheumatology 2022 20:106
  12. There is growing concern about the long-term cardiovascular health of patients with juvenile idiopathic arthritis (JIA). In this study we assessed the association between JIA polygenic risk and cardiovascular ...

    Authors: Sarah L. N. Clarke, Hannah J. Jones, Gemma C. Sharp, Kayleigh E. Easey, Alun D. Hughes, Athimalaipet V. Ramanan and Caroline L. Relton
    Citation: Pediatric Rheumatology 2022 20:105
  13. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition of immune dysregulation primarily driven by the cytokine interferon gamma. It can be either a genetic or acquired disorder associated wi...

    Authors: Allison Guild, Jordan Fritch, Sachit Patel, Adam Reinhardt and Melissa Acquazzino
    Citation: Pediatric Rheumatology 2022 20:104
  14. Little is known about the disposition to autoimmune diseases (ADs) among children diagnosed with JIA. In this study, we provide a comprehensive overview of the prevalence of and factors associated with ADs in ...

    Authors: Joeri W. van Straalen, Sytze de Roock, Gabriella Giancane, Ekaterina Alexeeva, Elena Koskova, Pablo Mesa-del-Castillo Bermejo, Francesco Zulian, Adele Civino, Davide Montin, Nico M. Wulffraat, Nicolino Ruperto and Joost F. Swart
    Citation: Pediatric Rheumatology 2022 20:103
  15. To describe long-term outcomes in JDM using patient questionnaires and link to longitudinal, prospectively collected data for each patient within the Juvenile Dermatomyositis Cohort and Biomarker Study, UK and...

    Authors: C. Boros, L. McCann, S. Simou, D. Cancemi, N. Ambrose, C. A. Pilkington, M. Cortina-Borja and L. R Wedderburn
    Citation: Pediatric Rheumatology 2022 20:102
  16. Sjogren’s syndrome (SS) is a rare chronic autoimmune disease involving exocrine glands presenting with sicca syndrome, recurrent parotitis and other extraglandular stigmata. SS is well characterized in the adu...

    Authors: Adam Bartholomeo, Shean Aujla, Meryle Eklund, Cheryl Kerrigan, Ellen Riemer and Mileka Gilbert
    Citation: Pediatric Rheumatology 2022 20:101
  17. Juvenile idiopathic arthritis (JIA) describes heterogenous categories of chronic inflammatory rheumatic conditions of unknown origin in children and adolescents. Epidemiological data in the literature vary, de...

    Authors: Gerd Horneff, Julia Borchert, Ria Heinrich, Simon Kock, Pascal Klaus, Heike Dally, Christine Hagemann, Joanna Diesing and Tonio Schönfelder
    Citation: Pediatric Rheumatology 2022 20:100
  18. Diagnosing synovial inflammation by administration of gadolinium-based contrast agents is limited by invasiveness and possible side effects, especially in children and adolescents.

    Authors: Britta Huch, Kilian Stumpf, Anna-Katinka Bracher, Volker Rasche, Daniel Vogele, Catharina Schütz, Aleš Janda, Meinrad Beer and Henning Neubauer
    Citation: Pediatric Rheumatology 2022 20:99
  19. The epidemiology and clinical presentation of systemic juvenile idiopathic arthritis (sJIA) in the Afro-Caribbean population is not well described.

    Authors: A. Felix, F. Delion, B. Suzon, S. Pallara-Sirven, N. Elenga, P. Quartier, F. Louis-Sidney, M. Dramé and Y. Hatchuel
    Citation: Pediatric Rheumatology 2022 20:98
  20. Evaluation of costs and short-term cost-effectiveness of infliximab plus methotrexate (IFX + MTX); triple therapy of hydroxychloquine, sulphasalazine, and methotrexate (TRIPLE); or methotrexate monotherapy (MT...

    Authors: Maarit Tarkiainen, Pirjo Tynjälä, Paula Vähäsalo, Kristiina Aalto, Liisa Kröger, Katariina Rebane, Pekka Lahdenne and Janne Martikainen
    Citation: Pediatric Rheumatology 2022 20:97
  21. Etanercept (ETN) and adalimumab (ADA) are considered equally effective biologicals in the treatment of arthritis in juvenile idiopathic arthritis (JIA) but no studies have compared their impact on patient-repo...

    Authors: Joeri W. van Straalen, Sytze de Roock, Gabriella Giancane, Alessandro Consolaro, Marite Rygg, Ellen B. Nordal, Nadina Rubio-Pérez, Marija Jelusic, Jaime De Inocencio, Jelena Vojinovic, Nico M. Wulffraat, Patricia C. J. Bruijning-Verhagen, Nicolino Ruperto and Joost F. Swart
    Citation: Pediatric Rheumatology 2022 20:96
  22. Systemic diseases of pediatric onset are more frequent in the Afro-Caribbean population. We performed a study of patients followed in the French overseas departments of America (FOAD) for pediatric systemic lu...

    Authors: Arthur Felix, Frederique Delion, Benoit Suzon, Elise Martin, Anais Ogrizek, M’hamed Mohamed Sahnoun, Claudia Hospice, Aurelie Armougon, Emma Cuadro, Narcisse Elenga, Moustapha Dramé, Brigitte Bader-Meunier, Christophe Deligny and Yves Hatchuel
    Citation: Pediatric Rheumatology 2022 20:95
  23. Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis is a term used to describe systemic vasculitides that affect small and medium-sized blood vessels. Granulomatosis with Polyangiitis (GPA), a type...

    Authors: Alexandra Theisen, Carrie L. Phillips and Martha Rodriguez
    Citation: Pediatric Rheumatology 2022 20:94
  24. Adolescents and young adults (AYA) with rheumatologic diseases are at high risk for poor outcomes and gaps in care when transitioning from pediatric to adult care. However, tools for evaluating transition read...

    Authors: Jordan E. Roberts, Olha Halyabar, Carter R. Petty, Maria Alfieri, Brittany Esty, Johnathan Dallas, Melissa Hazen, Sandra Stein and Mary Beth F. Son
    Citation: Pediatric Rheumatology 2022 20:93
  25. The peculiar presentation of overlap syndrome in children makes precise diagnosis difficult. Children with overlap syndrome may or may not have specific antibodies. We present the case of a 12-year-old girl di...

    Authors: Kan-Hsuan Lin and Jun-Kai Kao
    Citation: Pediatric Rheumatology 2022 20:92
  26. Transcriptome profiling of blood cells is an efficient tool to study the gene expression signatures of rheumatic diseases. This study aims to improve the early diagnosis of pediatric rheumatic diseases by inve...

    Authors: My Kieu Ha, Esther Bartholomeus, Luc Van Os, Julie Dandelooy, Julie Leysen, Olivier Aerts, Vasiliki Siozopoulou, Eline De Smet, Jan Gielen, Khadija Guerti, Michel De Maeseneer, Nele Herregods, Bouchra Lechkar, Ruth Wittoek, Elke Geens, Laura Claes…
    Citation: Pediatric Rheumatology 2022 20:91
  27. Systemic autoinflammatory diseases (SAIDs) are hyperinflammatory and immune-dysregulation conditions that present in childhood. This kind of disease is a rare disease with early-onset, severe condition and dif...

    Authors: Yandie Li, Meiping Yu and Meiping Lu
    Citation: Pediatric Rheumatology 2022 20:90
  28. Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease with osteoarticular and cutaneous involvements as its main manifestations. Acne conglobata as a s...

    Authors: Shengyan Liu, Xia Wu, Yihan Cao, Zhaohui Li, Yuchen Liu, Mingwei Ma and Chen Li
    Citation: Pediatric Rheumatology 2022 20:88
  29. Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is a clinical syndrome of unclear etiology. PFAPA has generally been considered a non-hereditary fever syndrome; however, this ha...

    Authors: Kristen L. Dammeyer, Amanda Schneider, Max M. April and Philip J. Kahn
    Citation: Pediatric Rheumatology 2022 20:87
  30. Blau syndrome (BS) is a rare autoinflammatory disorder with NOD2 gain-of-function mutation and characterized by autoactivation of the NFκB pathway. Classically considered a disease of high penetrance, reports on

    Authors: Shao-Yu Chang, Naotomo Kambe, Wen-Lang Fan, Jing-Long Huang, Wen-I Lee and Chao-Yi Wu
    Citation: Pediatric Rheumatology 2022 20:86
  31. The objectives were to assess changes in radiological disease activity in children with chronic non-bacterial osteomyelitis (CNO) receiving pamidronate therapy and to test a modified radiological index for non...

    Authors: C. M. Andreasen, R. F. Klicman, T. Herlin, E. M. Hauge and A. G. Jurik
    Citation: Pediatric Rheumatology 2022 20:85
  32. With juvenile idiopathic arthritis (JIA), there are several protocols and practices used worldwide for the transition from paediatric to adult care. In this study, we examined the transferral rates and disease...

    Authors: Katriina Mikola, Katariina Rebane, Ellen Dalen Arnstad, Lillemor Berntson, Anders Fasth, Mia Glerup, Troels Herlin, Hannu Kautiainen, Susan Nielsen, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Veronika Rypdal, Marek Zak and Kristiina Aalto
    Citation: Pediatric Rheumatology 2022 20:84
  33. Documentation of critical data elements is a focus of the Pediatric Rheumatology Care and Outcomes Improvement Network to aid in clinical care and research for patients with juvenile idiopathic arthritis. We a...

    Authors: Meghan E. Ryan, Andrew Warmin, Bryce A. Binstadt, Colleen K. Correll, Emily Hause, Patricia Hobday, Alison Lerman, Shawn A. Mahmud, Mona M. Riskalla, Zachary Shaheen, Richard K. Vehe and Danielle R. Bullock
    Citation: Pediatric Rheumatology 2022 20:83
  34. Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is generally regarded as the most common autoinflammatory disease, but the epidemiology of the disease is largely unknown...

    Authors: Karin Rydenman, Hanna Fjeld, Josefine Hätting, Stefan Berg, Anders Fasth and Per Wekell
    Citation: Pediatric Rheumatology 2022 20:82
  35. Limited joint mobility (LJM), previously known as cheiroarthropathy, refers to the presence of reduced extension at the finger joints in people with diabetes and may be associated with scleroderma-like syndrom...

    Authors: Greta Mastrangelo, Alessandra Meneghel, Giorgia Martini, Carlo Moretti and Francesco Zulian
    Citation: Pediatric Rheumatology 2022 20:81
  36. Although a satisfactory disease control is nowadays achievable in most patients with JIA, a substantial proportion of them still do not respond adequately or reach long-term drug-free remission. According to c...

    Authors: Marco Burrone, Marta Mazzoni, Roberta Naddei, Angela Pistorio, Maddalena Spelta, Silvia Scala, Elisa Patrone, Marco Garrone, Maria Lombardi, Luca Villa, Giulia Pascale, Roberto Cavanna, Nicolino Ruperto, Angelo Ravelli and Alessandro Consolaro
    Citation: Pediatric Rheumatology 2022 20:80
  37. Sjögren disease in children and adolescents (pedSD) presents differently than adult disease. Diagnosis and classification are controversial, optimal treatment is unknown and outcomes are poorly understood. Her...

    Authors: Rachel L. Randell, Sara M. Stern, Heather Van Mater, Laura E. Schanberg, Scott M. Lieberman and Matthew L. Basiaga
    Citation: Pediatric Rheumatology 2022 20:79
  38. A20 haploinsufficiency (HA20) is a newly introduced autosomal dominant autoinflammatory disorder, also known as Behcet’s-like disease. Some of the most common symptoms of the disease are recurrent oral, genita...

    Authors: Nahid Aslani, Kosar Asnaashari, Nima Parvaneh, Mohammad Shahrooei, Maryam Sotoudeh-Anvari, Farhad Shahram and Vahid Ziaee
    Citation: Pediatric Rheumatology 2022 20:78
  39. Peripheral gangrene is rarely documented as a possible complication of Kawasaki disease (KD). There are many causes of peripheral gangrene, and the common cause is in situ thrombosis or embolism. Most cases ar...

    Authors: Nanjun Zhang, Li Yu, Zhongxian Xiong, Yimin Hua, Hongyu Duan, Lina Qiao, Kaiyu Zhou and Chuan Wang
    Citation: Pediatric Rheumatology 2022 20:77
  40. Authors: Kentaro Nishi, Masao Ogura, Naotaka Tamai, Masafumi Gima, Kentaro Ide, Goro Koinuma, Koichi Kamei and Shuichi Ito
    Citation: Pediatric Rheumatology 2022 20:76

    The original article was published in Pediatric Rheumatology 2022 20:60

  41. Multisystem inflammatory syndrome in children (MIS-C) is a febrile syndrome that is observed in the pediatric population following severe acute respiratory syndrome 2 (SARS-CoV-2) infection. Vaccines have prev...

    Authors: Andy Liu, Alexa Love, Sophie Katz, Anna Patrick, David Parra, Natasha Halasa and Michael R. Miller
    Citation: Pediatric Rheumatology 2022 20:74
  42. Kinesiophobia may hinder physical performance measures and functional quality of life in children with juvenile idiopathic arthritis (JIA). This study aims to quantify differences in physical function in patie...

    Authors: Leandra U. Woolnough, Logan Lentini, Sharareh Sharififar, Cong Chen and Heather K. Vincent
    Citation: Pediatric Rheumatology 2022 20:73
  43. During childhood, the most common periodic fever is periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. The effective treatment and prevention of febrile attacks improve t...

    Authors: Seyed Reza Raeeskarami, Payman Sadeghi, Mahdieh Vahedi, Kosar Asna Ashari, Mahdieh Mousavi T. and Vahid Ziaee
    Citation: Pediatric Rheumatology 2022 20:72
  44. Pulmonary complications of rheumatic diseases may cause functional impairment and increase mortality. However, reports regarding detection of lung involvement in children with treatment-naive, newly diagnosed ...

    Authors: Hua Huang, Yabin Hu, Yufen Wu, Fei Ding, Xuemei Xu, Yingying Jin, Yanliang Jin and Yixiao Bao
    Citation: Pediatric Rheumatology 2022 20:71
  45. Non-criteria antiphospholipid antibodies (NC-aPL) are a relatively undefined subgroup of antiphospholipid antibodies (aPL). Knowledge about NC-aPL in adults is limited and even less is known in pediatric patie...

    Authors: Shawn A. Mahmud, Danielle R. Bullock, Colleen K. Correll, Patricia M. Hobday, Mona M. Riskalla, Richard K. Vehe and Bryce A. Binstadt
    Citation: Pediatric Rheumatology 2022 20:70
  46. For children with the multisystem inflammatory syndrome(MIS-C), intravenous immunoglobulins (IVIG) with or without methylprednisolone are the most effective treatment. In this study, IVIG combined with methylp...

    Authors: İlker Devrim, Elif Böncüoğlu, Elif Kıymet, Şahika Şahinkaya, Miray Yılmaz Çelebi, Ela Cem, Mine Düzgöl, Kamile Ötiken Arıkan, Aybüke Akaslan Kara, Dorukhan Besin, Gamze Vuran, Pınar Seven, Timur Meşe, Hasan Ağın and Nuri Bayram
    Citation: Pediatric Rheumatology 2022 20:69
  47. Biological treatment and treat-to-target approaches guide the achievement of inactive disease and clinical remission in Autoinflammatory Diseases (AID). However, there is limited evidence addressing optimal ta...

    Authors: Tatjana Welzel, Lea Oefelein, Marinka Twilt, Marc Pfister, Jasmin B. Kuemmerle-Deschner and Susanne M. Benseler
    Citation: Pediatric Rheumatology 2022 20:67
  48. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare form of vasculitis in children. SARS-CoV-2, the virus that causes COVID-19 infection, seems to trigger autoimmunity and new-onse...

    Authors: Maria C. Bryant, L. Terry Spencer and Ali Yalcindag
    Citation: Pediatric Rheumatology 2022 20:65

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