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  1. Content type: Short Report

    Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We s...

    Authors: Florence A. Aeschlimann, Lars Grosse-Wortmann, Susanne M. Benseler, Ronald M. Laxer, Diane Hebert and Rae S.M. Yeung

    Citation: Pediatric Rheumatology 2016 14:56

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  2. Content type: Review

    Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. The pathogenesis of JIA is thought to be the result of a combination of host genetic and environmental triggers. However, ...

    Authors: Anouk Verwoerd, Nienke M. Ter Haar, Sytze de Roock, Sebastiaan J. Vastert and Debby Bogaert

    Citation: Pediatric Rheumatology 2016 14:55

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  3. Content type: Research article

    There is a critical shortage of pediatric rheumatologists in the US. Substantial travel to clinics can impose time and monetary burdens on families. The aim of this study was to evaluate the cost of in-person ...

    Authors: Elizabeth A. Kessler, Ashley K. Sherman and Mara L. Becker

    Citation: Pediatric Rheumatology 2016 14:54

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  4. Content type: Research article

    Parents struggle when making treatment decisions for children with arthritis or other chronic conditions. Understanding their decision-making process is an essential step towards improving the decision-making ...

    Authors: Ellen A. Lipstein, Daniel J. Lovell, Lee A. Denson, Sandra C. Kim, Charles Spencer and Maria T. Britto

    Citation: Pediatric Rheumatology 2016 14:53

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  5. Content type: Case Report

    High-dose intravenous immune globulins (IVIg) are frequently used in refractory juvenile dermatomyositis (JDM) but are often poorly tolerated. High-dose recombinant human hyaluronidase-facilitated subcutaneous...

    Authors: Fabian Speth, Johannes-Peter Haas and Claas H. Hinze

    Citation: Pediatric Rheumatology 2016 14:52

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  6. Content type: Review

    The deficiency of Adenosine Deaminase 2 (DADA2) is a new autoinflammatory disease characterised by an early onset vasculopathy with livedoid skin rash associated with systemic manifestations, CNS involvement a...

    Authors: Roberta Caorsi, Federica Penco, Francesca Schena and Marco Gattorno

    Citation: Pediatric Rheumatology 2016 14:51

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  7. Content type: Research article

    To investigate the utilization of health care services before and after transfer from pediatric to adult rheumatology care in clinical practice.

    Authors: Melissa L. Mannion, Fenglong Xie, John Baddley, Lang Chen, Jeffrey R. Curtis, Kenneth Saag, Jie Zhang and Timothy Beukelman

    Citation: Pediatric Rheumatology 2016 14:49

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  8. Content type: Research article

    Adolescents with Juvenile Idiopathic Arthritis (JIA) are at risk for physical, emotional, social and role challenges that negatively impact quality of life. Peer mentoring has been shown to improve positive he...

    Authors: Jennifer Stinson, Sara Ahola Kohut, Paula Forgeron, Khush Amaria, Mary Bell, Miriam Kaufman, Nadia Luca, Stephanie Luca, Lauren Harris, Charles Victor and Lynn Spiegel

    Citation: Pediatric Rheumatology 2016 14:48

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  9. Content type: Research article

    Fibromyalgia (FM) is a common pain condition characterized by widespread musculoskeletal pain and tenderness. Pregabalin is an approved treatment for adults in the United States, but there are no approved trea...

    Authors: Lesley M. Arnold, Kenneth N. Schikler, Lucinda Bateman, Tahira Khan, Lynne Pauer, Pritha Bhadra-Brown, Andrew Clair, Marci L. Chew and Joseph Scavone

    Citation: Pediatric Rheumatology 2016 14:46

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  10. Content type: Research article

    Adherence to treatment in children with juvenile idiopathic arthritis (JIA) is associated with better outcomes. Assessing patient adherence in JIA, as well as attitudes and beliefs about prescribed treatments,...

    Authors: Karine Toupin April, Johanne Higgins and Debbie Ehrmann Feldman

    Citation: Pediatric Rheumatology 2016 14:45

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  11. Content type: Research article

    Adolescents with juvenile fibromyalgia (JFM) tend to be very sedentary and avoid participation in physical activity. A prior study suggested that JFM patients show altered biomechanics compared to healthy adol...

    Authors: Susan T. Tran, Staci Thomas, Christopher DiCesare, Megan Pfeiffer, Soumitri Sil, Tracy V. Ting, Sara E. Williams, Gregory D. Myer and Susmita Kashikar-Zuck

    Citation: Pediatric Rheumatology 2016 14:43

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  12. Content type: Meeting abstracts

    P1 Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis

    Authors: Lampros Fotis, Nur Shaikh, Kevin Baszis, Anthony French, Phillip Tarr, Sriharsha Grevich, Peggy Lee, Sarah Ringold, Brian Leroux, Hannah Leahey, Megan Yuasa, Jessica Foster, Jeremy Sokolove, Lauren Lahey, William Robinson, Joshua Newsom…

    Citation: Pediatric Rheumatology 2016 14(Suppl 1):41

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    This article is part of a Supplement: Volume 14 Supplement 1

  13. Content type: Research article

    To compare physical activity (PA) in children with juvenile idiopathic arthritis (JIA) with controls and to analyse the effect of disease specific factors on PA in children with JIA treated according to curren...

    Authors: G. J. F. Joyce Bos, Otto T. H. M. Lelieveld, Wineke Armbrust, Pieter J. J. Sauer, Jan H. B. Geertzen and Pieter U. Dijkstra

    Citation: Pediatric Rheumatology 2016 14:42

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  14. Content type: Review

    Juvenile idiopathic arthritis (JIA) is a clinically diverse and genetically complex autoimmune disease. Currently, there is very limited understanding of the potential underlying mechanisms that result in the ...

    Authors: Rachelle Donn, Chiara De Leonibus, Stefan Meyer and Adam Stevens

    Citation: Pediatric Rheumatology 2016 14:40

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  15. Content type: Research article

    The Mediterranean fever (MEFV) gene codes for protein pyrin, one of the regulators of inflammasome activity in innate immune cells. Mutations in this gene are considered the primary cause of Familial Mediterranea...

    Authors: Jelena Milenković, Jelena Vojinović, Maruša Debeljak, Nataša Toplak, Dragana Lazarević, Tadej Avčin, Tatjana Jevtović-Stoimenov, Dušica Pavlović, Vladmila Bojanić, Maja Milojković, Gordana Kocić and Andrej Veljković

    Citation: Pediatric Rheumatology 2016 14:39

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  16. Content type: Review

    The syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA syndrome) is the most common cause of periodic fever in childhood. The current pharmacological treatment includes c...

    Authors: Federica Vanoni, Katerina Theodoropoulou and Michaël Hofer

    Citation: Pediatric Rheumatology 2016 14:38

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  17. Content type: Case Report

    A small percentage of children with Henoch-Schönlein purpura (HSP) develop a chronic form of the disease that often requires prolonged corticosteroid therapy. Disease modifying anti-rheumatic agents (DMARDs) o...

    Authors: Lampros Fotis, Paul V. Tuttle IV, Kevin W. Baszis, Peri H. Pepmueller, Terry L. Moore and Andrew J. White

    Citation: Pediatric Rheumatology 2016 14:37

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  18. Content type: Research article

    There is a lack of published evidence on the importance of methotrexate (MTX) dose and route of administration on both its efficacy and adverse events in children with Juvenile Idiopathic Arthritis (JIA). We a...

    Authors: J. Fráňová, Š. Fingerhutová, K. Kobrová, R. Srp, D. Němcová, J. Hoza, M. Uher, M. Saifridová, L. Linková and P. Doležalová

    Citation: Pediatric Rheumatology 2016 14:36

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  19. Content type: Review

    Defective regulation of type I interferon response is associated with severe inflammatory phenotypes and autoimmunity. Type I interferonopathies are a clinically heterogenic group of Mendelian diseases with a ...

    Authors: Stefano Volpi, Paolo Picco, Roberta Caorsi, Fabio Candotti and Marco Gattorno

    Citation: Pediatric Rheumatology 2016 14:35

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  20. Content type: Research article

    To analyze the clinical presentation and complications of varicella zoster virus (VZV) infection in children with rheumatic diseases treated with immunosuppressive medication such as biological disease-modifyi...

    Authors: Raphael Leuvenink, Florence Aeschlimann, Walter Baer, Gerald Berthet, Elvira Cannizzaro, Michael Hofer, Daniela Kaiser, Silke Schroeder, Ulrich Heininger and Andreas Woerner

    Citation: Pediatric Rheumatology 2016 14:34

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  21. Content type: Review

    In the recent years, musculoskeletal ultrasound (MSUS) has been regarded as especially promising in the assessment of juvenile idiopathic arthritis (JIA), as a reliable method to precisely document and monitor...

    Authors: Silvia Magni-Manzoni

    Citation: Pediatric Rheumatology 2016 14:33

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  22. Content type: Case Report

    Camptodactyly-arthropathy-coxa vara-pericarditis (CACP, OMIM: #208250) syndrome is a rare autosomal recessive disease that can be difficult to recognise not only because of its wide clinical variability but al...

    Authors: Bram Peters, Janneke H. M. Schuurs-Hoeijmakers, Joris Fuijkschot, Annette Reimer, Michiel van der Flier, Dorien Lugtenberg and Esther P.A.H. Hoppenreijs

    Citation: Pediatric Rheumatology 2016 14:32

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  23. Content type: Research article

    Juvenile Idiopathic Arthritis is the most common chronic pediatric rheumatic disease. The announcement of Juvenile Idiopathic Arthritis poses for parents a number of challenges that make it hard to accept a di...

    Authors: Aurélie Chausset, Anne-Laure Gominon, Nathalie Montmaneix, Stéphane Echaubard, Séverine Guillaume-Czitrom, Benoit Cambon, Cécile Miele, Emmanuelle Rochette and Etienne Merlin

    Citation: Pediatric Rheumatology 2016 14:31

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  24. Content type: Review

    Complex regional pain syndrome (CRPS) is a chronic, intensified localized pain condition that can affect children and adolescents as well as adults, but is more common among adolescent girls. Symptoms include ...

    Authors: Rotem Weissmann and Yosef Uziel

    Citation: Pediatric Rheumatology 2016 14:29

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  25. Content type: Review

    Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood, with JIA-associated uveitis its most common extra-articular manifestation. JIA-associated uveitis is a potentially sight-t...

    Authors: Sarah L. N. Clarke, Ethan S. Sen and Athimalaipet V. Ramanan

    Citation: Pediatric Rheumatology 2016 14:27

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  26. Content type: Review

    Considerable therapeutic advances for the treatment of vasculitis of the young have been made in the past 10 years, including the development of outcome measures that facilitate clinical trial design. Notably,...

    Authors: Despina Eleftheriou and Paul A. Brogan

    Citation: Pediatric Rheumatology 2016 14:26

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  27. Content type: Short Report

    Juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by persistent chronic arthritis. Disease risk is believed to be influenced by both genetic and environmental factors. It is well estab...

    Authors: G. N. Goulielmos, R. C. Chiaroni-Clarke, D. G. Dimopoulou, M. I. Zervou, M. Trachana, P. Pratsidou-Gertsi, A. Garyfallos and J. A. Ellis

    Citation: Pediatric Rheumatology 2016 14:25

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  28. Content type: Research article

    Temporomandibular joint (TMJ) arthritis is seen very often (38–87 %) in children with juvenile idiopathic arthritis (JIA). With contrast enhanced magnetic resonance imaging (MRI) we can detect more cases of TM...

    Authors: Zane Dāvidsone, Jeļena Eglīte, Arina Lazareva, Sarmīte Dzelzīte, Ruta Šantere, Dace Bērziņa and Valda Staņēviča

    Citation: Pediatric Rheumatology 2016 14:24

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  29. Content type: Review

    Juvenile idiopathic arthritis (JIA), as a chronic condition, is associated with significant disease- and treatment-related morbidity, thus impacting children’s quality of life. In order to optimize JIA managem...

    Authors: Alessandro Consolaro, Gabriella Giancane, Benedetta Schiappapietra, Sergio Davì, Serena Calandra, Stefano Lanni and Angelo Ravelli

    Citation: Pediatric Rheumatology 2016 14:23

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  30. Content type: Research article

    Kawasaki disease (KD) is a systemic vasculitis with an acute and self-limited course. The incidence of KD differs widely among ethnic groups and is higher in the Asian population. In Italy, no recent data are ...

    Authors: Angela Mauro, Marianna Fabi, Monica Da Frè, Paolo Guastaroba, Elena Corinaldesi, Giovanni Battista Calabri, Teresa Giani, Gabriele Simonini, Franca Rusconi and Rolando Cimaz

    Citation: Pediatric Rheumatology 2016 14:22

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  31. Content type: Research article

    Although joint involvement is the second most common clinical manifestation after skin involvement in patients with Henoch-Schönlein purpura (HSP), it has not been well characterized. The aim of this study was...

    Authors: Xuehong Wang, Yongmei Zhu, Laiqiang Gao, Shuyue Wei, Youyou Zhen and Qiang Ma

    Citation: Pediatric Rheumatology 2016 14:20

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  32. Content type: Case Report

    Mevalonate kinase deficiency is a metabolic autoinflammatory syndrome caused by mutations in the MVK gene, mevalonate kinase, the key enzyme in the non-sterol isoprenoid biosynthesis pathway. Two phenotypes of me...

    Authors: Skaiste Peciuliene, Birute Burnyte, Rymanta Gudaitiene, Skirmante Rusoniene, Nijole Drazdiene, Arunas Liubsys and Algirdas Utkus

    Citation: Pediatric Rheumatology 2016 14:19

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  33. Content type: Review

    Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition with an unclear pathophysiological mechanism affecting different parts of the body. If untreated, the disease can lead to ...

    Authors: Faiz Karim, Jan Loeffen, Wichor Bramer, Lauren Westenberg, Rob Verdijk, Martin van Hagen and Jan van Laar

    Citation: Pediatric Rheumatology 2016 14:18

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  34. Content type: Review

    The juvenile spondyloarthropathies (JSpA) are a group of related rheumatic diseases characterized by involvement of peripheral large joints, axial joints, and entheses (enthesitis) that begin in the early year...

    Authors: María Martha Katsicas and Ricardo Russo

    Citation: Pediatric Rheumatology 2016 14:17

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  35. Content type: Review

    Sports participation can be an integral part of adolescent development with numerous positive short and long-term effects. Despite these potential benefits very high levels of physical activity, during skeleta...

    Authors: Viran de Silva, Michael Swain, Carolyn Broderick and Damien McKay

    Citation: Pediatric Rheumatology 2016 14:16

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  36. Content type: Research article

    Epidemiological research reveals that the incidence of allergic diseases and that of autoimmune diseases have been increasing in parallel, raising an interest in a potential link between the two disorders. How...

    Authors: Chien-Heng Lin, Cheng-Li Lin, Te-Chun Shen and Chang-Ching Wei

    Citation: Pediatric Rheumatology 2016 14:15

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  37. Content type: Research article

    Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood system...

    Authors: Sampath Prahalad, Courtney E. McCracken, Lori A. Ponder, Sheila T. Angeles-Han, Kelly A. Rouster Stevens, Larry B. Vogler, Carl D. Langefeld and Susan D. Thompson

    Citation: Pediatric Rheumatology 2016 14:14

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  38. Content type: Research article

    Despite the wealth of clinical research carried out in children with juvenile idiopathic arthritis (JIA), little is known about the emotional experiences of their parents. This article describes the predominan...

    Authors: Oralia Gómez-Ramírez, Michele Gibbon, Roberta Berard, Roman Jurencak, Jayne Green, Lori Tucker, Natalie Shiff and Jaime Guzman

    Citation: Pediatric Rheumatology 2016 14:13

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  39. Content type: Review

    Patients with Systemic Lupus Erythematosus (SLE) are at increased risk for infections. Vaccination is a powerful tool to prevent infections, even in immunocompromised patients. Most non-live vaccines are immun...

    Authors: Ingrid Herta Rotstein Grein, Noortje Groot, Marcela Ignacchiti Lacerda, Nico Wulffraat and Gecilmara Pileggi

    Citation: Pediatric Rheumatology 2016 14:12

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  40. Content type: Short Report

    Methotrexate (MTX) intolerance is a frequent problem of long-term treatment in juvenile idiopathic arthritis (JIA). Mutations in the methylentetrahydrofolate reductase (MTHFR) gene may increase toxicity of MTX...

    Authors: Andrea Scheuern, Nadine Fischer, Joseph McDonald, Hermine I. Brunner, Johannes-Peter Haas and Boris Hügle

    Citation: Pediatric Rheumatology 2016 14:11

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  41. Content type: Review

    BD is a systemic inflammatory disease with a variable vasculitis. Paediatric onset is very rare and carries a strong genetic component. Oral ulcers and fever of unknown origin are frequent at onset and difficu...

    Authors: Isabelle Koné-Paut

    Citation: Pediatric Rheumatology 2016 14:10

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  42. Content type: Research article

    There is not yet a commonly accepted, standardized approach in the treatment of juvenile idiopathic uveitis when initial steroid therapy is insufficient. We sought to assess current practice patterns within a ...

    Authors: Lauren A. Henderson, David Zurakowski, Sheila T. Angeles-Han, Andrew Lasky, C. Egla Rabinovich and Mindy S. Lo

    Citation: Pediatric Rheumatology 2016 14:9

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  43. Content type: Research article

    The association between rheumatoid arthritis (RA) and periodontitis is well established. Some children with juvenile idiopathic arthritis (JIA) phenotypically resemble adults with RA, characterized by the pres...

    Authors: Lauren Lange, Geoffrey M. Thiele, Courtney McCracken, Gabriel Wang, Lori A. Ponder, Sheila T. Angeles-Han, Kelly A. Rouster-Stevens, Aimee O. Hersh, Larry B. Vogler, John F. Bohnsack, Shelly Abramowicz, Ted R. Mikuls and Sampath Prahalad

    Citation: Pediatric Rheumatology 2016 14:8

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  44. Content type: Research article

    Various pathways involved in the pathogenesis of sJIA have been identified through gene expression profiling in peripheral blood mononuclear cells (PBMC), but not in neutrophils. Since neutrophils are importan...

    Authors: Ebun Omoyinmi, Raja Hamaoui, Annette Bryant, Mike Chao Jiang, Trin Athigapanich, Despina Eleftheriou, Mike Hubank, Paul Brogan and Patricia Woo

    Citation: Pediatric Rheumatology 2016 14:7

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