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  1. Axial involvement in children with enthesitis-related arthritis (ERA) has characteristics that differ from those of peripheral involvement. This study characterized their clinical characteristics and treatment.

    Authors: Yanli Guo, Yuying Fang, Tonghao Zhang, Yuting Pan, Panpan Wang, Zhidan Fan and Haiguo Yu
    Citation: Pediatric Rheumatology 2023 21:13
  2. To characterize the clinical features and outcomes of childhood-onset primary Sjögren’s syndrome (pSS).

    Authors: Yinv Gong, Haimei Liu, Guomin Li, Tao Zhang, Yifan Li, Wanzhen Guan, Qiaoqian Zeng, Qianying Lv, Xiaomei Zhang, Wen Yao, Yu Shi, Hong Xu and Li Sun
    Citation: Pediatric Rheumatology 2023 21:11
  3. In a chronic pain-causing disease such as juvenile idiopathic arthritis, the quality of coping with pain is crucial. Parents have a substantial influence on their children’s pain-coping strategies. This study ...

    Authors: Maria Backström, Hanna Vuorimaa, Maarit Tarkiainen, Eliisa Löyttyniemi, Liisa Kröger, Kristiina Aalto, Katariina Rebane, Kati Markula-Patjas, Merja Malin, Sirja Sard, Paula Keskitalo, Katja Korkatti, Minna-Maija Grönlund, Milja Möttönen, Heini Pohjankoski, Maiju Hietanen…
    Citation: Pediatric Rheumatology 2023 21:9
  4. Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome, caused by biallelic pathogenic mutations in the proteoglycan 4 (PRG4) gene, is characterized by early-onset camptodactyly, noninflammatory arthrop...

    Authors: İlknur Bağrul, Serdar Ceylaner, Yasemin Tasci Yildiz, Serife Tuncez, Elif Arslanoglu Aydin, Esra Bağlan, Semanur Ozdel and Mehmet Bülbül
    Citation: Pediatric Rheumatology 2023 21:8
  5. Dry synovitis (DS) is a rare entity as only a few cases have been reported to date. We describe the clinical features, radiological manifestations and course of DS in comparison with rheumatoid factor negative...

    Authors: Lien De Somer, Brigitte Bader-Meunier, Sylvain Breton, Sara Brachi, Carine Wouters and Francesco Zulian
    Citation: Pediatric Rheumatology 2023 21:7
  6. Delay in diagnosis and access to specialist care is a major problem for many children and young people with rheumatic disease in sub-Saharan Africa. Most children with symptoms of rheumatic disease present to ...

    Authors: Angela Migowa, Sasha Bernatsky, Anthony Ngugi, Helen E. Foster, Peter Muriuki, Adelaide Lusambili and Stanley Luchters
    Citation: Pediatric Rheumatology 2023 21:6
  7. In the midst of the COVID-19 coronavirus pandemic, a new disease that affects children has arisen called multisystem inflammatory syndrome in children (MIS-C). Several research articles focusing on its medical as...

    Authors: Henrik Hjelmgren, Karin Andersson, Jessica Widegren, Erika Bergman, Anna Vermé, Karina Mördrup, Marcus Öhlander and Cecilia Bartholdson
    Citation: Pediatric Rheumatology 2023 21:5
  8. Familial Mediterranean Fever (FMF) is the most common monogentic autoinflammatory disease. FMF results from mutations in MEFV, which lead to a pro-inflammatory state and increased production of Interleukin 1 beta...

    Authors: Shiran Pinchevski-Kadir, Maya Gerstein, Oren Pleniceanu, Yonatan Yacobi, Asaf Vivante, Ortal Erez Granat, Shiri Spielman, Rotem Semo Oz and Irit Tirosh
    Citation: Pediatric Rheumatology 2023 21:4
  9. Despite new and better treatments for juvenile dermatomyositis (JDM), not all patients with moderate severity disease respond adequately to first-line therapy. Those with refractory disease remain at higher ri...

    Authors: Matthew A. Sherman, Hanna Kim, Katelyn Banschbach, Amanda Brown, Harry L. Gewanter, Bianca Lang, Megan Perron, Angela Byun Robinson, Jacob Spitznagle, Cory Stingl, Grant Syverson, Heather O. Tory, Charles H. Spencer and Stacey E. Tarvin
    Citation: Pediatric Rheumatology 2023 21:3
  10. Familial Mediterranean Fever (FMF) patients are required to adhere to a life-long treatment with colchicine, primarily for preventing amyloidosis. As some patients may be asymptomatic for long periods of time,...

    Authors: Keren Cohen, Shiri Spielman, Rotem Semo-Oz, Guy Bitansky, Maya Gerstein, Yonatan Yacobi, Asaf Vivante and Irit Tirosh
    Citation: Pediatric Rheumatology 2023 21:2
  11. A significant number of patients in pediatric rheumatology suffer from ongoing disease activity into adulthood and thus need to be transferred into adult care. Transition as a structured individual process of ...

    Authors: Luca Samuel Boeker, Jasmin Beate Kuemmerle-Deschner, Sebastian Jonas Saur, Jens Klotsche, Gabriele Erbis and Sandra Hansmann
    Citation: Pediatric Rheumatology 2022 20:121
  12. Ethosuximide and other anti-epileptic drugs have been reported to cause idiosyncratic reactions such as lupus-like syndromes, with elevated antinuclear antibody (ANA) levels. Herein, we present a case of a gir...

    Authors: Lillemor Berntson and Gunnar Liminga
    Citation: Pediatric Rheumatology 2022 20:120
  13. Kawasaki disease (KD) is usually treated with high-dose intravenous immunoglobulin (IVIg) as severe infectious and other diseases. Due to issues that are associated with immunoglobulin preparation, such as the...

    Authors: Fuyu Ito, Toshiaki Oharaseki, Daisuke Tsukui, Yoshitaka Kimura, Tamiko Yanagida, Fukuko Kishi, Yoshio Yamakawa, Yosuke Kameoka, Shoichi Suzuki, Kazuko Uno, Osamu Suzuki, Noriko N. Miura, Naohito Ohno, Kei Takahashi, Hajime Kono and Kazuo Suzuki
    Citation: Pediatric Rheumatology 2022 20:119
  14. Adenosine deaminase 2 (ADA2) deficiency is an inherited autoinflammatory syndrome caused by a defect in the ADA2 gene. Most common manifestations include peripheral vasculopathy, early-onset stroke, immunodeficie...

    Authors: Z. Lucane, Z. Davidsone, I. Micule, M. Auzenbaha and N. Kurjane
    Citation: Pediatric Rheumatology 2022 20:118
  15. Haptoglobin (Hp), a liver derived acute phase inflammatory protein (APP), has scarcely been studied in juvenile idiopathic arthritis (JIA). Hp can occur in blood as two isoforms (Hp1 and Hp2) in precursor and...

    Authors: Lillemor Berntson, Jakob Palm, Fredrik Axling, Peter Zarelius, Per M. Hellström and Dominic-Luc Webb
    Citation: Pediatric Rheumatology 2022 20:117
  16. Authors: Timothy Hahn, Carrie Daymont, Timothy Beukelman, Brandt Groh, Kimberly Hays, Catherine April Bingham and Lisabeth Scalzi
    Citation: Pediatric Rheumatology 2022 20:116

    The original article was published in Pediatric Rheumatology 2022 20:107

  17. Incomplete Kawasaki disease (IKD) initially presenting as retropharyngeal abnormality is very rare and is prone to misdiagnosis and missed diagnosis, often leading to poor prognosis. Most patients were misdiag...

    Authors: Yong-chao Chen, Hong-guang Pan, De-sheng Jia, Hao-cheng Wang, Lan Li and Yi-shu Teng
    Citation: Pediatric Rheumatology 2022 20:115
  18. Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We perfo...

    Authors: Elisabet Berthold, Alma Dahlberg, Anna Jöud, Helena Tydén, Bengt Månsson, Fredrik Kahn and Robin Kahn
    Citation: Pediatric Rheumatology 2022 20:114

    The Correction to this article has been published in Pediatric Rheumatology 2024 22:62

  19. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) to compare treatment initiation strategies for systemic juvenile idiopathic arthritis (sJIA). First...

    Authors: Timothy Beukelman, George Tomlinson, Peter A. Nigrovic, Anne Dennos, Vincent Del Gaizo, Marian Jelinek, Mary Ellen Riordan, Laura E. Schanberg, Shalini Mohan, Erin Pfeifer and Yukiko Kimura
    Citation: Pediatric Rheumatology 2022 20:113
  20. Multisystem inflammatory syndrome in children (MIS-C) is a new syndrome with some clinical manifestations similar to Kawasaki disease (KD), which is difficult to distinguish.

    Authors: Tong Tong, Xuefeng Yao, Zhe Lin, Yijing Tao, Jiawen Xu, Xiao Xu, Zhihao Fang, Zhimin Geng, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang, Yujia Wang and Fangqi Gong
    Citation: Pediatric Rheumatology 2022 20:112
  21. The most severe complication associated with giant coronary aneurysm in children with Kawasaki disease is ischemic cardiomyopathy (ICM) caused by thrombosis. Addition of tissue plasminogen activator, Alteplase...

    Authors: Yanqiu Chu, Yunming Xu, Ce Wang, Xiaona Yu, Quanmei Ma and Hong Wang
    Citation: Pediatric Rheumatology 2022 20:111
  22. Since the onset of the recent COVID-19 pandemic, there have been growing concerns regarding multisystem inflammatory syndrome in children (MIS-C). This study aims to describe the clinico-epidemiological profil...

    Authors: Angela Migowa, Pauline Samia, Sean del Rossi, Oliver Ombeva Malande, Jasmit Shah, Chemutai Kenei, Joy Ayaya, Daisy Jeruto, Laura Oyiengo and Laura Lewandowski
    Citation: Pediatric Rheumatology 2022 20:110
  23. Biologic disease-modifying antirheumatic drugs (bDMARDs) have changed the treatment of juvenile idiopathic arthritis (JIA) patients notably, as bDMARDs enable substantially more patients to achieve remission. ...

    Authors: Job Gieling, Bart van den Bemt, Esther Hoppenreijs and Ellen Schatorjé
    Citation: Pediatric Rheumatology 2022 20:109
  24. Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoinflammatory bone disorder with predominantly paediatric onset. Children present with multifocal osteolytic lesions accompanied by bone pain and soft...

    Authors: Dita Cebecauerová, Hana Malcová, Veronika Koukolská, Zuzana Kvíčalová, Ondřej Souček, Lukáš Wagenknecht, Jiří Bronský, Zdeněk Šumník, Martin Kynčl, Marek Cebecauer and Rudolf Horváth
    Citation: Pediatric Rheumatology 2022 20:108
  25. Children with juvenile idiopathic arthritis (JIA) who achieve a drug free remission often experience a flare of their disease requiring either intraarticular steroids (IAS) or systemic treatment with disease m...

    Authors: Timothy Hahn, Carrie Daymont, Timothy Beukelman, Brandt Groh, Kimberly Hays, Catherine April Bingham and Lisabeth Scalzi
    Citation: Pediatric Rheumatology 2022 20:107

    The Publisher Correction to this article has been published in Pediatric Rheumatology 2022 20:116

  26. Autoinflammatory diseases are rare disorders of the innate immune system characterized by fever and other signs of inflammation. A feared complication of autoinflammatory diseases is the development of AA amyl...

    Authors: G. E. Legger, C. W. E. Dermer, A. F. Brunger, P. L. A. van Daele and H. L. A. Nienhuis
    Citation: Pediatric Rheumatology 2022 20:106
  27. There is growing concern about the long-term cardiovascular health of patients with juvenile idiopathic arthritis (JIA). In this study we assessed the association between JIA polygenic risk and cardiovascular ...

    Authors: Sarah L. N. Clarke, Hannah J. Jones, Gemma C. Sharp, Kayleigh E. Easey, Alun D. Hughes, Athimalaipet V. Ramanan and Caroline L. Relton
    Citation: Pediatric Rheumatology 2022 20:105
  28. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition of immune dysregulation primarily driven by the cytokine interferon gamma. It can be either a genetic or acquired disorder associated wi...

    Authors: Allison Guild, Jordan Fritch, Sachit Patel, Adam Reinhardt and Melissa Acquazzino
    Citation: Pediatric Rheumatology 2022 20:104
  29. Little is known about the disposition to autoimmune diseases (ADs) among children diagnosed with JIA. In this study, we provide a comprehensive overview of the prevalence of and factors associated with ADs in ...

    Authors: Joeri W. van Straalen, Sytze de Roock, Gabriella Giancane, Ekaterina Alexeeva, Elena Koskova, Pablo Mesa-del-Castillo Bermejo, Francesco Zulian, Adele Civino, Davide Montin, Nico M. Wulffraat, Nicolino Ruperto and Joost F. Swart
    Citation: Pediatric Rheumatology 2022 20:103
  30. To describe long-term outcomes in JDM using patient questionnaires and link to longitudinal, prospectively collected data for each patient within the Juvenile Dermatomyositis Cohort and Biomarker Study, UK and...

    Authors: C. Boros, L. McCann, S. Simou, D. Cancemi, N. Ambrose, C. A. Pilkington, M. Cortina-Borja and L. R Wedderburn
    Citation: Pediatric Rheumatology 2022 20:102
  31. Sjogren’s syndrome (SS) is a rare chronic autoimmune disease involving exocrine glands presenting with sicca syndrome, recurrent parotitis and other extraglandular stigmata. SS is well characterized in the adu...

    Authors: Adam Bartholomeo, Shean Aujla, Meryle Eklund, Cheryl Kerrigan, Ellen Riemer and Mileka Gilbert
    Citation: Pediatric Rheumatology 2022 20:101
  32. Juvenile idiopathic arthritis (JIA) describes heterogenous categories of chronic inflammatory rheumatic conditions of unknown origin in children and adolescents. Epidemiological data in the literature vary, de...

    Authors: Gerd Horneff, Julia Borchert, Ria Heinrich, Simon Kock, Pascal Klaus, Heike Dally, Christine Hagemann, Joanna Diesing and Tonio Schönfelder
    Citation: Pediatric Rheumatology 2022 20:100
  33. Diagnosing synovial inflammation by administration of gadolinium-based contrast agents is limited by invasiveness and possible side effects, especially in children and adolescents.

    Authors: Britta Huch, Kilian Stumpf, Anna-Katinka Bracher, Volker Rasche, Daniel Vogele, Catharina Schütz, Aleš Janda, Meinrad Beer and Henning Neubauer
    Citation: Pediatric Rheumatology 2022 20:99
  34. The epidemiology and clinical presentation of systemic juvenile idiopathic arthritis (sJIA) in the Afro-Caribbean population is not well described.

    Authors: A. Felix, F. Delion, B. Suzon, S. Pallara-Sirven, N. Elenga, P. Quartier, F. Louis-Sidney, M. Dramé and Y. Hatchuel
    Citation: Pediatric Rheumatology 2022 20:98
  35. Evaluation of costs and short-term cost-effectiveness of infliximab plus methotrexate (IFX + MTX); triple therapy of hydroxychloquine, sulphasalazine, and methotrexate (TRIPLE); or methotrexate monotherapy (MT...

    Authors: Maarit Tarkiainen, Pirjo Tynjälä, Paula Vähäsalo, Kristiina Aalto, Liisa Kröger, Katariina Rebane, Pekka Lahdenne and Janne Martikainen
    Citation: Pediatric Rheumatology 2022 20:97
  36. Etanercept (ETN) and adalimumab (ADA) are considered equally effective biologicals in the treatment of arthritis in juvenile idiopathic arthritis (JIA) but no studies have compared their impact on patient-repo...

    Authors: Joeri W. van Straalen, Sytze de Roock, Gabriella Giancane, Alessandro Consolaro, Marite Rygg, Ellen B. Nordal, Nadina Rubio-Pérez, Marija Jelusic, Jaime De Inocencio, Jelena Vojinovic, Nico M. Wulffraat, Patricia C. J. Bruijning-Verhagen, Nicolino Ruperto and Joost F. Swart
    Citation: Pediatric Rheumatology 2022 20:96
  37. Systemic diseases of pediatric onset are more frequent in the Afro-Caribbean population. We performed a study of patients followed in the French overseas departments of America (FOAD) for pediatric systemic lu...

    Authors: Arthur Felix, Frederique Delion, Benoit Suzon, Elise Martin, Anais Ogrizek, M’hamed Mohamed Sahnoun, Claudia Hospice, Aurelie Armougon, Emma Cuadro, Narcisse Elenga, Moustapha Dramé, Brigitte Bader-Meunier, Christophe Deligny and Yves Hatchuel
    Citation: Pediatric Rheumatology 2022 20:95
  38. Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis is a term used to describe systemic vasculitides that affect small and medium-sized blood vessels. Granulomatosis with Polyangiitis (GPA), a type...

    Authors: Alexandra Theisen, Carrie L. Phillips and Martha Rodriguez
    Citation: Pediatric Rheumatology 2022 20:94
  39. Adolescents and young adults (AYA) with rheumatologic diseases are at high risk for poor outcomes and gaps in care when transitioning from pediatric to adult care. However, tools for evaluating transition read...

    Authors: Jordan E. Roberts, Olha Halyabar, Carter R. Petty, Maria Alfieri, Brittany Esty, Johnathan Dallas, Melissa Hazen, Sandra Stein and Mary Beth F. Son
    Citation: Pediatric Rheumatology 2022 20:93
  40. The peculiar presentation of overlap syndrome in children makes precise diagnosis difficult. Children with overlap syndrome may or may not have specific antibodies. We present the case of a 12-year-old girl di...

    Authors: Kan-Hsuan Lin and Jun-Kai Kao
    Citation: Pediatric Rheumatology 2022 20:92
  41. Transcriptome profiling of blood cells is an efficient tool to study the gene expression signatures of rheumatic diseases. This study aims to improve the early diagnosis of pediatric rheumatic diseases by inve...

    Authors: My Kieu Ha, Esther Bartholomeus, Luc Van Os, Julie Dandelooy, Julie Leysen, Olivier Aerts, Vasiliki Siozopoulou, Eline De Smet, Jan Gielen, Khadija Guerti, Michel De Maeseneer, Nele Herregods, Bouchra Lechkar, Ruth Wittoek, Elke Geens, Laura Claes…
    Citation: Pediatric Rheumatology 2022 20:91
  42. Systemic autoinflammatory diseases (SAIDs) are hyperinflammatory and immune-dysregulation conditions that present in childhood. This kind of disease is a rare disease with early-onset, severe condition and dif...

    Authors: Yandie Li, Meiping Yu and Meiping Lu
    Citation: Pediatric Rheumatology 2022 20:90
  43. Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease with osteoarticular and cutaneous involvements as its main manifestations. Acne conglobata as a s...

    Authors: Shengyan Liu, Xia Wu, Yihan Cao, Zhaohui Li, Yuchen Liu, Mingwei Ma and Chen Li
    Citation: Pediatric Rheumatology 2022 20:88
  44. Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is a clinical syndrome of unclear etiology. PFAPA has generally been considered a non-hereditary fever syndrome; however, this ha...

    Authors: Kristen L. Dammeyer, Amanda Schneider, Max M. April and Philip J. Kahn
    Citation: Pediatric Rheumatology 2022 20:87
  45. Blau syndrome (BS) is a rare autoinflammatory disorder with NOD2 gain-of-function mutation and characterized by autoactivation of the NFκB pathway. Classically considered a disease of high penetrance, reports on

    Authors: Shao-Yu Chang, Naotomo Kambe, Wen-Lang Fan, Jing-Long Huang, Wen-I Lee and Chao-Yi Wu
    Citation: Pediatric Rheumatology 2022 20:86

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