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Table 2 Demographic, clinical, and laboratory characteristics of 32 patients with persistent antiphospholipid antibody (aPL) profiles

From: The clinical relevance of different antiphospholipid antibody profiles in pediatric rheumatology patients

 

Triple aPL Positive

LA Positive with/without aCL or aβ2GPI

LA Negative with aCL and/or aβ2GPI

 

(n:9)

(n:12)

(n:11)

aCL/aβ2GPI Level

   

 aCL/aβ2GPI IgG/M 20-39U

1 (11%)

3 (25%)

7 (64%)

 aCL/aβ2GPI IgG/M ≥ 40U

8 (89%)

2 (17%)

4 (36%)

Demographics

   

 Mean Age at Presentation

13.2 ± 4.65

14.7 ± 2.57

13.8 ± 4.95

 Female

7 (78%)

11 (92%)

10 (91%)

 White

5 (56%)

7 (58%)

6 (55%)

 Black

2 (22%)

-

1 (9%)

 Hispanic

1 (11%)

3 (25%)

2 (18%)

 Asian

1 (11%)

1 (8%)

1 (9%)

Lupus Classification

5 (56%)

7 (58%)

5 (45%)

Thrombosis

5 (56%)

3 (25%)

1 (9%)*

 Venous

4

-

1

 Arterial

-

-

-

 Both Venous and Arterial

-

1

-

 Microvascular

1

2

-

Non-thrombotic aPL Manifestations$

5 (56%)

9 (75%)

1 (9%)**

 Thrombocytopenia#

1

4

-

 Autoimmune Hemolytic Anemia

2

2

1

 Cardiac Valve Disease

-

1

-

 Livedo Reticularis/Racemosa

1

1

-

 Migraines***

3

2

-

 Chorea ***

1

-

-

  1. LA: lupus anticoagulant; aCL: anticardiolipin antibody; and aβ2GPI: anti-β2 glycoprotein-I antibody. *In a patient with aCL IgM > 40U initially, then 20-30U on repeat testing; #Platelets < 150,000 /µl twice with no other diagnosis. **Autoimmune hemolytic anemia occurred in a patient with initially low-risk profile, who later developed a high-risk profile with aCL IgM > 40. ***Controversial aPL-related manifestations, which may be more relevant in pediatric population. $Of 15 patients with non-thrombotic aPL manifestations, nine (60%) had lupus classification (six with cytopenia) and six (40%) did not have an SLE classification (four with cytopenia)