Table 2 Main findings of connective tissue nevus as compared to juvenile localized scleroderma
From: Connective tissue nevus misdiagnosed as juvenile localized scleroderma
CTN* | JLS** | ||
|---|---|---|---|
Clinical Appearance | Borders | Poorly- or undefined | Defined |
Skin colour | Normal | Hyperemic or hyper-hypopigmented | |
Skin adnexa | Present/increased | Decreased or absent | |
Autoantibodies (%) | Antinuclear antibodies (ANA) | Negative | 30–70 |
MRI Abnormalities (%) | Subcutaneous atrophy | 5.9 | 70–90 |
Bone marrow edema | Absent | 5–36 | |
Muscle edema | Absent | 15–71 | |
Muscle fat replacement | Absent | 7.1 | |
Sarcopenia | Absent | 57 | |
Perifascial enhancement | 11.8 | 16–35 | |
Pathology | Collagen fibers | Grossly thickened | Thickened |
Skin adnexa | Normally represented | Decreased/absent | |
Inflammatory infiltrate | Absent | Perivascular, perineural | |