Fig. 5
From: Potential regulatory role of the Nrf2/HMGB1/TLR4/NF-κB signaling pathway in lupus nephritis
The proportion of plasma cells detected by flow cytometry. a Typical representative flow scatter plots for each group: The scatter plot is divided into four sections, the upper right quadrant is double positive cells with the antigen markers indicated by the X-axis and Y-axis respectively, TLR4+CXCR4+ PCs or CD27+CD38+ PC, while the lower left quadrant is the opposite, TLR4−CXCR4− PCs or CD27−CD38.− PC. The upper left and lower right quadrants represent cells that are marked positive only for the Y-axis parameter or the X-axis parameter, respectively. b Flow histograms. The proportion of PCs and PC in the kidney and blood of the model group are significantly increased, compared to that of the control group. Nrf2 overexpression lowers this proportion in kindeys and blood than that in the model group.(*Compared with the control group, P < 0.05; #Compared with the model group, P < 0.05, n = 3 per group)