Fig. 2
From: Potential regulatory role of the Nrf2/HMGB1/TLR4/NF-κB signaling pathway in lupus nephritis
Nrf2, HMGB1, TLR4, and NF- κB mRNA expression in each group, detected by q-PCR. a-d Nrf2 mRNA expression is significantly decreased and HMGB1, TLR4, and NF-κB expression is significantly increased in the model group compared to that in the control group; in Nrf2 vector group, the expression of Nrf2 mRNA is significantly upregulated, while the expression of HMGB1, TLR4, and NF- κB mRNA is significantly downregulated. (*Compared to the control group, P < 0.05; #Compared to the model group, P < 0.05, n = 3 per group)