Adolescent and caregiver preferences for juvenile idiopathic arthritis treatment: a discrete-choice experiment

Table 1 Attributes and levels for the discrete-choice experiment

Technical attribute label	Caregiver/adolescent-facing attribute label	Caregiver-facing attribute levels	Adolescent-facing attribute levels
Symptom control ^a	Improvement in symptom control	From very poor to poor	From very poor to poor
		From very poor to fair	From very poor to fair
		From very poor to good	From very poor to good
		From very poor to very good	From very poor to very good
Time until next flare-up ^b	Amount of time until the next flare-up	1 month	1 month
		3 months	3 months
		5 months	5 months
		9 months	9 months
Stomachache, nausea, and vomiting ^c	Stomachache, feeling sick or being sick (throwing up/vomiting) because of the medicine	None	None
		Your child has a stomachache but does not feel like vomiting	Tummy pain (but you do not feel like you will throw up)
		Your child feels like vomiting but does not vomit	You feel like you will throw up, but you do not throw up
		Your child vomits	You throw up
Headache	Headaches because of the medicine	No headaches	No headaches
Headache	Headaches because of the medicine	Your child has headaches	You have headaches
Need for combination therapy (methotrexate or steroids, or both)^d	Additional medicines, such as steroids and methotrexate, needed to keep JIA under control	No	No
		Yes	Yes
Mode and frequency of administration ^e	How the medicine is taken	Tablets or liquid/syrup ^f twice a day	Tablets or liquid twice a day
		Injection every week	Injection every week
		Injection every 2 weeks	Injection every 2 weeks
		IV infusion (IV or drip) every month	IV infusion (IV or drip) every month

IV Intravenous, JIA Juvenile idiopathic arthritis. Note: The survey instrument for adults used slightly different language than the survey instrument for adolescents
^aLevels for this attribute were developed based on the findings from Davies et al. [16]
^bLevels for this attribute were developed based on the findings from Ruperto et al. [17]
^cLevels for this attribute were developed based on the findings from Brunner et al. [14]
^dLevels for this attribute were developed based on the findings from Fleischmann et al. [18]
^eLevels for this attribute were developed based on the findings from Ruperto et al. [17]
^fThe United States survey labelled this attribute level as “tablets or liquid twice a day” and the United Kingdom survey labelled this attribute level as “tablets or syrup twice a day”

ISSN: 1546-0096