Fig. 1

The changes of rash, inflammatory indicators, IS, imaging findings, and GDS during the treatment process. A The treatment process including glucocorticoid, ruxolitinib, thalidomide and tocilizumab. C-reactive protein and erythrocyte sedimentation rate values fluctuated with the different medications. B Rashes of varying severity at different ages. The first picture (3 years old) was the sinus that formed after one year of treatment with glucocorticoids. The second picture (5 years old) was the skin manifestation after two years of treatment with ruxolitinib, and the last picture (7 years old) was the rash when the disease relapsed. C The interferon score values during the treatment. D Cranial computed tomography images. E Cranial magnetic resonance imaging. F Griffiths Developmental Scale during the treatment