Table 4 Receiver operating characteristic curve analysis of serum cytokines in KFD, SJIA, and KD
From: Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease
Compared to SJIA patients without MAS | ||||||
AUC | Cut-off Value | Sensitivity (%) | Specificity (%) | 95%CI | p-value | |
IFN-γ (pg/ml) | 0.99 | > 8.48 | 96 | 94.7 | 0.98–1.0 | < 0.0001 |
IL-6 (pg/ml) | 0.92 | < 47.72 | 80 | 94.7 | 0.84–0.99 | < 0.0001 |
IFN-γ/IL-6 | 1 | > 0.45 | 100 | 100 | 1.0–1.0 | < 0.0001 |
IL-2 (pg/ml) | 0.64 | < 5.25 | 36 | 94.7 | 0.48–0.80 | 0.1 |
Compared to patients with KD | ||||||
AUC | Cut-off Value | Sensitivity (%) | Specificity (%) | 95%CI | p-value | |
IFN-γ (pg/ml) | 0.97 | > 8.56 | 85.2 | 94.74 | 0.94–1.0 | < 0.0001 |
IL-6 (pg/ml) | 0.8 | < 50.45 | 51.9 | 94.7 | 0.67–0.93 | 0.0006 |
IFN-γ/IL-6 | 0.998 | > 0.45 | 96.3 | 100 | 0.99–1.0 | < 0.0001 |
IL-2 (pg/ml) | 0.63 | < 5.25 | 22.2 | 94.7 | 0.47–0.79 | 0.13 |