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Table 3 Serum cytokine levels of patients in KFD, SJIA, and KD

From: Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease

Without MAS

With MAS

 

KFD (n = 19)

SJIA (n = 25)

KD (n = 27)

*p-value

**p-value

KFD (n = 6)

SJIA (n = 6)

***p-value

IFN-γ (pg/ml)

39.3 (19.6–65.4)

2.8 (1.1–4.4)

2.6 (1.46–4.82)

0.006

0.007

76.9 (29.5–255.8)

108.3 (15.4–365.8)

0.85

IL-10 (pg/ml)

4.4 (3.9–7.7)

4.2 (3.2–6.0)

8.54 (5.45–12.17)

0.72

0.08

15.2 (5.5–22.8)

19.3 (10.9–33.9)

0.36

IL-6 (pg/ml)

13.4 (6.2–37.9)

102 (52.1–234.2)

55.26 (26.02–103.52)

0.007

0.018

21.3 (9.1–47.6)

65.1 (32.0–154.4)

0.3

IFN-γ/IL-6

2.0 (1.4–3.5)

0.02 (0.008–0.05)

0.05 (0.03–0.08)

3E-04

0.0003

4.5 (3.5–6.7)

0.63 (0.21–2.37)

0.12

TNF-a (pg/ml)

0.87 (0.12–1.83)

0.82 (0.33–1.78)

2.23 (1.3–2.93)

0.41

0.032

2.02 (0.46–3.21)

0.83 (0.19–2.34)

0.33

IL-4 (pg/ml)

2.2 (1.43–3.22)

2.06 (1.08–3.10)

2.85 (2.18–3.72)

0.61

0.028

2.07 (1.73–2.36)

1.82 (1.3–4.05)

0.42

IL-2 (pg/ml)

1.4 (0.6–3.19)

3.23 (0.6–9.99)

2.25 (1.21–3.89)

0.016

0.07

2.86 (2.14–4.63)

5.44 (0.1–14.62)

0.27

  1. Data expressed as median (interquartile range). Variables were analyzed by Unpaired Welch’s t-test
  2. KFD Kikuchi-Fujimoto disease, SJIA Systemic Juvenile Idiopathic Arthritis, KD kawasaki disease, MAS macrophage activation syndrome
  3. *p-value and **p-value represented differences between patients with KFD and SJIA, KFD and KD, respectively
  4. ***p-value was comparison between patients with KFD and SJIA with MAS