Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease

Table 2 Serum cytokine levels in KFD, SJIA, and KD

	KFD (n = 25)	SJIA (n = 31)	KD (n = 27)	*p-value	**p-value
IFN-γ (pg/ml)	41.65 (21.04–70.74)	3.33 (1.3–6.27)	2.6 (1.46–4.82)	0.16	0.01
IL-10 (pg/ml)	5.5 (4.04–8.97)	4.79 (3.81–10.9)	8.54 (5.45–12.17)	0.57	0.22
IL-6 (pg/ml)	17.17 (6.65–40.62)	99.66 (49.19–181.8)	55.26 (26.02–103.52)	0.004	0.019
IFN-γ/IL-6	3.16 (1.54–5.5)	0.03 (0.01–0.19)	0.05 (0.03–0.08)	0.0001	< 0.0001
TNF-a (pg/ml)	0.9 (0.28–2.14)	0.82 (0.3–1.82)	2.23 (1.3–2.93)	0.93	0.14
IL-4 (pg/ml)	2.2 (1.43–2.87)	2.04 (1.22–3.16)	2.85 (2.18–3.72)	0.34	0.01
IL-2 (pg/ml)	2.17 (0.9–3.95)	3.23 (0.6–9.99)	2.25 (1.21–3.89)	0.008	0.13

Data expressed as median (interquartile range). Variables were analyzed by Unpaired Welch’s t-test
KFD Kikuchi-Fujimoto disease, SJIA Systemic Juvenile Idiopathic Arthritis, KD kawasaki disease, MAS macrophage activation syndrome
^*p-value represented difference between patients with KFD and SJIA
^**p-value was comparison between patients with KFD and KD

ISSN: 1546-0096