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Table 1 Baseline demographic and disease characteristics

From: Significant pain decrease in children with non-systemic Juvenile Idiopathic Arthritis treated to target: results over 24 months of follow up

Ā 

Arm 1

Sequential

Monotherapy

(nā€‰=ā€‰31)

Arm 2

MTXā€‰+ā€‰6wks

Prednisolone

(nā€‰=ā€‰32)

Arm 3

MTXā€‰+ā€‰

Etanercept

(nā€‰=ā€‰29)

Age (years), median (IQR)

9.0 (4.7ā€“12.9)

10.2 (6.6ā€“13.9)

8.6 (4.2ā€“12.4)

Symptom duration (mo.), median (IQR)

8.1 (5.5ā€“11.9)

5.9 (4.6ā€“13.3)

8.6 (5.2ā€“13.4)

ANA pos, n (%)

14 (45.2)

11 (34.4)

9 (31.0)

Female, n (%)

23 (74.2)

19 (59.4)

19 (65.5)

JIA Category

ā€‰ā€‰ā€‰ā€‰Oligo, n(%)

5 (16.1)

3 (9.4)

3 (10.3)

ā€‰ā€‰ā€‰ā€‰Oligoarticularā€‰<ā€‰6Ā months

1

1

3

ā€‰ā€‰ā€‰ā€‰Oligoarticularā€‰>ā€‰ā€‰=ā€‰6Ā months

4 (12.9)

2 (6.3)

0

ā€‰ā€‰ā€‰ā€‰Poly, n (%)

24 (77.4)

25 (78.1)

24 (82.8)

ā€‰ā€‰ā€‰ā€‰Psoriatic, n (%)

2 (6.4)

4 (12.5)

2 (6.9)

PGA mean (SD) in mm

46.4ā€‰Ā±ā€‰15.4

49.7ā€‰Ā±ā€‰16.1

51.2ā€‰Ā±ā€‰16.6

VAS patient/parent general well-being, mean (SD) in mm

48.9ā€‰Ā±ā€‰21.9

56.3ā€‰Ā±ā€‰21.4

54.6ā€‰Ā±ā€‰22.6

VAS pain mean (SD) in mm

54.7ā€‰Ā±ā€‰20.0

54.5ā€‰Ā±ā€‰23.0

56.8ā€‰Ā±ā€‰22.7

CHAQ, mean (SD)

0.9ā€‰Ā±ā€‰0.7

1.1ā€‰Ā±ā€‰0.6

1.1ā€‰Ā±ā€‰0.5

CHQ-PF50

ā€‰ā€‰ā€‰ā€‰CHQ-PhS, mean (SD)

32.0ā€‰Ā±ā€‰13.4

30.1ā€‰Ā±ā€‰12.4

31.0ā€‰Ā±ā€‰12.2

ā€‰ā€‰ā€‰ā€‰CHQ-PsS, mean (SD)

45.4ā€‰Ā±ā€‰12.4

46.0ā€‰Ā±ā€‰10.5

47.7ā€‰Ā±ā€‰9.1

No. active joints, median (IQR)

7.0 (5.0ā€“13.0)

7.5 (6.0ā€“11.8)

8.0 (5.5ā€“13.0)

No. limited joints, median (IQR)

2.0 (0ā€“3.0)

2.0 (1.0ā€“3.8)

3.0 (1.5ā€“5.0)

ESR, median (IQR)

6.0 (2.0ā€“11.0)

6.0 (2.0ā€“23.5)

9.0 (3.5ā€“26.0)

JADAS-10, mean (SD)

16.5ā€‰Ā±ā€‰4.2

18.8ā€‰Ā±ā€‰4.4

18.8ā€‰Ā±ā€‰5.4

NSAID use, n (%)

26 (83.9)

27 (84.4)

25 (86.2)

  1. MTX methotrexate, oligo oligoarticular JIA, poly polyarticular RF-negative JIA, IQR interquartile range, ANA antinuclear antibodies, pos positive, psoriatic JIA with psoriasis, PGA physicianā€™s global assessment, VAS visual analogue scale, CHAQ Child Health Assessment Questionnaire, CHQ-PF50 Child Health Questionnaire parent form 50, CHQ-PhS Physical Summary Scale, CHQ-PsS Psychosocial Summary Score, No. number, ESR erythrocyte sedimentation rate, JADAS-10 juvenile arthritis disease activity score in up to maximum 10 joints. Missing follow-up data occurred in 4% for active joint count, in 4% for limited joint count and PGA, 7% for VAS patient/parent general wellbeing, 1% for VAS pain, 7% for CHAQ score, 14% for CHQ-PhS, 14% for CHQ-PsS and 16% for ESR