Table 3 Top 10 compounds predicted to have activity against JSpA as predicted via connectivity map
From: Identifying circRNA-associated-ceRNA networks in juvenile spondyloarthropathies patients
ID | Cmap name | Dose | Cell | Score | Description | Target |
|---|---|---|---|---|---|---|
BRD-K73794685 | azithromycin | 0.125 μm | THP1 | -0.45 | Bacterial 50 S ribosomal subunit inhibitor | MLNR |
BRD-K59037100 | oxybenzone | 0.125 μm | THP1 | -0.44 | Lipase inhibitor | LIPE |
BRD-A68009927 | daunorubicin | 0.08 μm | THP1 | -0.43 | RNA synthesis inhibitor |Topoisomerase inhibitor | TOP2A|TOP2B |
BRD-K76205745 | losartan | 0.25 μm | THP1 | -0.43 | Angiotensin receptor antagonist | AGTR1 |
BRD-K93208532 | apremilast | 2.22 μm | THP1 | -0.43 | Phosphodiesterase inhibitor | PDE4A|PDE4B|PDE4C|PDE4D|TNF|TNFRSF1A |
BRD-K49055432 | A-66 | 0.04 μm | THP1 | -0.42 | PI3K inhibitor | PIK3CA |
BRD-K64990520 | apocynin | 0.74 μm | THP1 | -0.42 | NADPH inhibitor | NOX3|NOX4 |
BRD-K89732114 | trifluoperazine | 10 μm | THP1 | -0.41 | Dopamine receptor antagonist | DRD2|ABCG2|CAMK2A|SCN4A|SCN9A|ADRA1A|CALM1|CALY|DRD4|HRH1|HTR2A|HTR2C|S100A4|TNNC1 |
BRD-A49399758 | desmopressin-acetate | 0.37 μm | THP1 | -0.41 | Vasopressin receptor agonist | AVPR2|AVPR1A|AVPR1B|OXTR |
BRD-K59715032 | pasireotide | 10 μm | THP1 | -0.4 | Somatostatin receptor agonist | SSTR1|SSTR2|SSTR3|SSTR5|GH1 |