Meningococcal ACWY conjugate vaccine immunogenicity in adolescents with primary or secondary immune deficiencies, a prospective observational cohort study

Table 1 Patient characteristics at baseline

Characteristics	Total cohort (n = 69)	Healthy controls (n = 75)
Female, n (%)	34 (49.3%)	36 (48.0%)
Age in years, median (IQR)	15.3 (13.7–17.0)	15·2 (14·9–15·5)
Disease, n (%)		N/A
Immune deficiencies ¹	33 (47.8%)
Autoimmune and auto-inflammatory diseases ²	20 (29.0%)
Uveitis	12 (17.4%)
Sickle cell disease	4 (5.8%)
Medication use, n (%)
NSAIDs	5 (7.2%)
Immunosuppressive drugs*	23 (33.3%)
Systemic corticosteroids	1 (1.4%)
Synthetic DMARDs	19 (27.5%)
Methotrexate	6 (8.7%)
Azathioprine	1 (1.4%)
Mycophenolate mofetil	11 (15.9%)
Other	1 (1.4%)
Biologic DMARDs	10 (14.5%)
Anti-TNF	7 (10.1%)
Anti-IL6	2 (2.9%)
Anti-IL1	1 (1.4%)

Abbreviations: DMARDS, disease-modifying anti-rheumatic drugs; IQR, interquartile range; N/A, not applicable. *including systemic corticosteroids, synthetic DMARDS, biologic DMARDS.
¹11 common variable immunodeficiency; 8 22Q11 syndrome; 3 chronic neutropenia; 3 specific polysaccharide antibody deficiency; 2 complement 2 deficiency; 1 bone marrow failure/allogeneic stem cell transplantation; 1 hyper IgE syndrome; 1 warts, hypogammaglobulinemia, infections and myelokathexis syndrome; 1 ataxia telangiectasia; 1 dysimmunoglobulinemia; 1 IgG subclass deficiency.
² 6 systemic lupus erythematosus; 3 mixed connective tissue disease; 3 juvenile dermatomyositis; 2 systemic sclerosis; 1 recurrent idiopathic pericarditis; 1 chronic recurrent multifocal osteomyelitis; 1 localized scleroderma; 1 eosinophilic granulomatosis with polyangiitis; 1 alopecia areata with dysimmunoglobulinemia; 1 adenosine deaminase 2 deficiency.

ISSN: 1546-0096