Table 2 Urine metabolite values in the juvenile idiopathic arthritis patients and controls

Median, (25%;75%)µg/L

p

Median, (25%;75%)µg/L

p

Median, (25%; 75%)

µg/L

p

Median, (25%; 75%)

µg/L

C19-steroids (androgens)

An

386

(197.7 ; 901.9)

0.003

575.66

(143.39 ; 847.7)

0.019

412.14

(195.7 ; 847.17)

0.008

1027.3

(635.93 ::1815.4)

Et

322.81

(161.99 ; 763.55)

0.09

513.98

(100.64 ; 801.78)

0.4

394.96

(133.79 : 875.92)

0.4

1083.13

(517.60 ; 2262.37)

DHEA

23.96

( 18.12 ; 115.51)

0.8

41.73

(23.26 ; 208.48)

0.8

22.94

(17.43 ; 178)

0.4

84.64

(32.7 ; 157.21)

16a−OH−DHEA

80.98

(16.93 ;184.35)

07

125.81

(41.37 ; 297.4)

0.9

93.25

(20.86 ; 240.19)

0.8

201.56

(.80.67 ; 378.087)

A5−3b,17a

13.88

)6. 57; 26.5)

0.0049

14.94

(0; 159.06)

0.07

19.03

(0.00; 175.92)

0.2

45.22

(11.03; 112.41)

A5−3b,17b

18.44

(0. 5; 58.45)

0.3

19.34

(0.5 ; 19.34)

0.31

20.91

(0.5 ; 44.91)

0.3

39.52

(4.24 ; 67.7)

A5T−16a

69.89

(25.18;187.62)

0.9

81.11

(25.11;183.22)

0.9

79.34

(32.86;210.62)

0.6

136.71

(102.88;443.62)

11−OH−An

258.05

(140.19;328.16)

0.0053

193.16

(122.67;476.65)

0.039

241.12

(44.47; 1281.82)

0.047

540.11

(256.35;750.63)

11−O−An

23.58

(16.15;30.91)

0.028

21.35

(18.63;40.38)

0.1

25.65

(17.6;29.15)

0.09

40.94

(31.03;68.16)

11−OH−Et

53.93

(32.22;143.80)

0.2

134.69

(24.96;159.60)

0.5

60.74

(27.94;172.20)

0.68

311.31

(192.76;555.11)

C21-steroids Pregnenolone and progesterone metabolites

PD

87.33

(22.35;154.31)

0.4

53.86

(24.95;150.32)

0.5

55.49

(29.01;217.23)

0.3

167.63

(82.29;251.39)

PT

243.94

(129.83;456.88)

0.007

221.14

(134.19;442.83)

0.2

279.72

(144.10;521.28)

0.001

534.55

(360.57;814.75)

P5D

62.65

(26.36;79.76)

0.015

38.94

(15.78;72.36)

0.013

47.28(29.65;102.80)

0.009

143.12

(89.79;191.43)

P5T−17a

92.30

(22.90;187.19)

0.11

91.35

(45.7;222.31)

0.3

97.89

(40.90;256.69)

0.2

236.23

(108.73;375.27)

Po−5b,3a

37.16

(19.60;63.17)

0.0001

28.40

(17.13;91.86)

0.08

45.78

(24.49;119)

0.1

76.18

(62.33;144.34)

Po−5a,3a

8.6

(4.37;11.15)

0.064

7.08

(4.80;15.49)

0.1

9.70

(0.00; 29.03)

0.1

12.19

(7.73; 83.24)

11−O−Pt

5.14

(2.39; 41.76)

0.0018

3.98

(2.21; 15.49)

0.03

9.10

(4.86;13.61)

0.8

11.83

(9.05;16.24)

THS

58.26

(38.47;119.66)

0.0065

79.51

(35.70;130.07)

0.1

70.71

(51.71;125.88)

0.16

93.25

(61.12;193.81)

Cortisol metabolites

F

39.51

(30.95;53.47)

0.025

35.64

(27.98;72.95)

0.7

52.76

(30.74;68.72)

0.5

68.94

(45.66;102.47)

THE

2030.35

(929.30;3716.08)

0.022

1881.50

(1079.42;2993.02)

0.6

2211.90

(1709.79;2867.23)

0.2

3308.17

(2853.92;4929.21

THF

846.06

(373.61;1043.06)

0.028

620.38

(414.52;885.59)

0.4

814.63

(526.79;1045.78)

0.3

1029.31

(817.97;1671.19)

a−THF

434.07

(337.48;755.61)

0.016

552.75

(354.94;621.4)

0.3

493.77

(46.30; 2137.91)

0.1

846.49

(378.17;1162.60)

a−Cl

617.24

(356.03;1043.48)

0.012

643.37

(395.74;840.70)

0.6

653.12

(504.40;954.33)

0.03

1187.74

(763.86;1677.21)

b−Cl

374.98

(278.97;773.43)

0.001

447.54

(262.38;789.72)

0.2

480.85

(411.58;586.12)

0.08

703.25

(535.32;1107.11)

a−C

74.67

(52.41;154.94)

0.002

85.60

(59.87;138.94)

0.07

106.13

(61.91;149.26)

0.08

167.22

(89.83;295.84)

b−C

223.18

(118.71;414.28)

0.014

298.90

(160.79;519.41)

0.045

329.43

(145.79;583.53)

0.07

447.79

(260.20;807.25)

6b−OH−F

85.51

(58.81;234.72)

0.02

94.19

(68.37;178.74)

0.1

126.28

(82.995;182.24)

0.5

247.6

(93.65;313.36)

20a−DHF

24.52

(11.98;29.30)

0.03

23.54

(15.96;33.74)

0.1

26.02

(.16.04;41.29)

0.3

36.31

(24.38;57.84)

Corticosterone metabolites

THA

88.06

(68.73;174.89)

0.034

86.80

(59.50;199.31)

0.49

121.73

(81.15;153.81)

0.07

225.99

(89.56;343.93)

THB

97.58

(53.39;157.32)

0.025

75.08

(54.44;169.64)

0.3

106.76

(81.92;196.15)

0.052

223.62

(124.41;274.19)

a−THB

153.63

(109.67;271.18)

0.053

163.06

(106.41;316.88)

0.3

161.34

(123.49;292.23)

0.09

286.74

(119.17;655.65)