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Table 3 Generalized estimating equation models predicting SLEDAI-2K with CMV infection, anti-CMV treatment and pp65 titers during follow-up

From: Clinical phenotypes and prognosis of cytomegalovirus infection in the pediatric systemic lupus erythematosus: a longitudinal analysis

Outcome: SLEDAI-2K

Beta coefficient (95%CI)

P value

Model 1: CMV vs. No CMV over time

 Time

-0.08(-0.11;-0.04)

<0.001

 No CMV

1(ref)

ref

 CMV

1.88(0.64;3.13)

0.003

 No CMV*Time

1(ref)

ref

 CMV*Time

-0.01(-0.05;0.04)

0.817

Model 2: Anti-CMV treatment vs. No treatment over time

 Time

-0.07(-0.09;-0.05)

<0.001

 No Treatment

1(ref)

ref

 Treatment

-1.50(-2.97;-0.02)

0.046

 No Treatment*Time

1(ref)

ref

 Treatment*Time

-0.06(-0.10;-0.02)

0.001

Model 3: pp65

 pp65

0.14(0.09;0.18)

<0.001

  1. Beta coefficient for ‘time’ represents the change of SLEDAI-2K over the follow-up period
  2. CI Confidence interval, SLEDAI-2K Systemic Lupus Erythematosus Disease Activity Index 2000
  3. * indicates the interaction between two variables