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Table 1 Clinical and demographic characteristics of the patients at the time of ETN measurement

From: Etanercept for patients with juvenile idiopathic arthritis: drug levels and influence of concomitant methotrexate: observational study

 

MTX group

n = 97

non-MTX group

n = 83

p value

Female (%)

62 (64)

47 (57)

0.32

Age (years), mean (SD)

7.5 (3.6)

8.6 (3.8)

0.037

Height (cm), mean (SD)

122 (23)

128 (239)

0.11

Weight (kg), mean (SD)

26.5 (13.0)

28.6 (13.7)

0.27

BMI, kg/ m2

16.6 (2.8)

16.5 (2.5)

0.77

BSA (m2), mean (SD)

0.94 (0.31)

1.00 (0.33)

0.17

Disease duration (years), mean (SD)

2.3 (2.4)

3.2 (2.8)

0.019

Diagnosis

  

0.74

 Oligoarthritis, persistent

17 (18)

18 (22)

 

 Oligoarthritis, extended

15 (15)

14 (17)

 

 Polyarthritis, RF-negative

57 (49)

40 (48)

 

 Polyarthritis, RF-positive

2 (2)

1 (1)

 

 Enthesitis related arthritis

4 (4)

7 (8)

 

 Psoriatic arthritis

1 (1)

2 (2)

 

 Undifferentiated arthritis

1 (1)

1 (1)

 

Uveitis, n (%)

9 (9)

2 (2)

0.066

Inflammatory bowel disease, n (%)

1 (1)

1(1)

0.99

Previous bDMARD, n (%)

10 (10)

15 (18)

0.13

 Etanercept

7

10

 

 Adalimumab

3

4

 

 Infliximab

2

4

 

 Tocilizumab

0

2

 

Concomitant treatment n (%)

 Other sDMARDs

6 (6)

32 (39)

< 0.001

 Prednisolone

4 (4)

7(8)

0.23

ESR (mm/h), mean (SD)

13.2 (14.0)

12.1 (12.1)

0.61

CRP (mg/l), mean (SD)

4.9 (12.6)

5.9 (13.5)

0.63

JADAS10, mean (SD)

10.0 (5.6)

9.7 (5.8)

0.56

PaGA, mean (SD)

3.3 (2.6)

2.6 (2.2)

0.10

PhGA, mean (SD)

3.1 (1.8)

2.7 (1.9)

0.14

HLA-B27 positive, n (%)

27 (28)

25 (30)

0.58

ANA, n (%)

31 (32)

23 (28)

0.54

Erosions, n (%)

21 (22)

16 (19)

0.60

  1. ETN etanercept, MTX methotrexate, BMI Body mass index, BSA Body surface area, RF Rheumatoid factor, bDMARD biological disease-modifying antirheumatic drug, sDMARD synthetic disease-modifying antirheumatic drug, ESR Erythrocyte sedimentation rate, CRP C-reactive protein, JADAS10 10-joint Juvenile Arthritis Disease Activity Score, PaGA Patient’s global assessment of wellbeing measured on a linear analogue scale (VAS), PhGA Physician’s global assessment of wellbeing measured on a VAS scale, HLA Human leucocyte antigen B27, ANA Antinuclear antibody