Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing

Table 1 Clinical Characteristics of Subjects with JIA

	J-11	J-12	J-13	J-14	J-15	J-17
Sex	F	F	M	F	F	F
Race	White	White	White	White	Asian	Asian
Age of onset	2	15	12	1	7	5
JIA category	Oligo	Poly	Oligo	Poly	Oligo	Oligo
Joint Count	1	18	2	17	1	1
Patient global assessment	4	9.5	4	4	1	2
Physician global assessment	3	6	6	9	2	2
CHAQ	1.12	2.30	0.25	2.12	0	2
JADAS-27	8	33.5	16.5	30.9	5	9
ANA	Negative	1:320	Negative	Negative	1:320	Negative
RF	ND	Negative	Negative	Negative	Negative	Negative
CCP status	Negative	> 250	Negative	Negative	80	Negative
B27	ND	Negative	Negative	Negative	Negative	Negative
Medications	Naproxen	Naproxen	None	Allergy med^*	None	None

Subject J-12 also had a diagnosis of cerebral palsy. Subject J-13 developed Crohn disease several months after diagnosis of arthritis. Subjects J-11 and J-12 were on a nonsteroidal anti-inflammatory drug (Naproxen) at baseline, but none of the others were on any medication to treat their joint symptoms. None of the subjects had received glucocorticoid drugs. Subject J-14 reported being on albuterol inhalers and intranasal fluticasone
Healthy control C14 was a 22-year-old non-Hispanic white female and C22 was a 25-year-old Asian female. Neither reported a history of autoimmune diseases or being on any medications at the time of participation

ISSN: 1546-0096