Table 3 JIA categories of patients with a family history of different ADs
Family history of AD, n (%) | ERA (n = 955) | oJIA (n = 3253) | pJIA RF- (n = 2273) | pJIA RF + (n = 373) | psJIA (n = 290) | sJIA (n = 949) | uJIA (n = 580) | P-value |
|---|---|---|---|---|---|---|---|---|
Psoriasis | 8 (0.8%) | 10 (0.3%) | 3 (0.1%) | 0 (0.0%) | 129 (44.5%) | 7 (0.7%) | 205 (35.3%) | < 0.01* |
AITD | 17 (1.8%) | 139 (4.3%) | 69 (3.0%) | 11 (2.9%) | 8 (2.8%) | 14 (1.5%) | 13 (2.2%) | < 0.01* |
RA | 17 (1.8%) | 37 (1.1%) | 53 (2.3%) | 14 (3.8%) | 3 (1.0%) | 7 (0.7%) | 10 (1.7%) | < 0.01* |
Ankylosing spondylitis | 103 (10.8%) | 1 (0.0%) | 5 (0.2%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 26(4.5%) | < 0.01* |
IBD | 11 (1.2%) | 27 (0.8%) | 14 (0.6%) | 2 (0.5%) | 2 (0.7%) | 4 (0.4%) | 8 (1.4%) | 0.31 |
JIA | 4 (0.4%) | 17 (0.5%) | 23 (1.0%) | 1 (0.3%) | 1 (0.3%) | 0 (0.0%) | 4 (0.7%) | 0.01* |
Asthma | 6 (0.6%) | 12 (0.4%) | 9 (0.4%) | 4 (1.1%) | 3 (1.0%) | 8 (0.8%) | 5 (0.9%) | 0.10 |
IDDM | 0 (0.0%) | 16 (0.5%) | 10 (0.4%) | 4 (1.1%) | 2 (0.7%) | 2 (0.2%) | 4 (0.7%) | 0.05* |
SLE | 2 (0.2%) | 7 (0.2%) | 11 (0.5%) | 1 (0.3%) | 3 (1.0%) | 5 (0.5%) | 2 (0.3%) | 0.18 |
Vitiligo | 1 (0.1%) | 12 (0.4%) | 12 (0.5%) | 1 (0.3%) | 0 (0.0%) | 2 (0.2%) | 1 (0.2%) | 0.58 |
Other autoimmune arthritis | 1 (0.1%) | 8 (0.2%) | 4 (0.2%) | 0 (0.0%) | 3 (1.0%) | 0 (0.0%) | 12(2.1%) | < 0.01* |
Celiac disease | 0 (0.0%) | 13 (0.4%) | 9 (0.4%) | 0 (0.0%) | 3 (1.0%) | 1 (0.1%) | 1 (0.2%) | 0.08 |
Other autoimmune disease | 1 (0.1%) | 10 (0.3%) | 6 (0.3%) | 0 (0.0%) | 2 (0.7%) | 0 (0.0%) | 6 (1.0%) | 0.02* |
Uveitis | 9 (0.9%) | 1 (0.0%) | 1 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 6 (1.0%) | < 0.01* |
Multiple sclerosis | 1 (0.1%) | 6 (0.2%) | 5 (0.2%) | 0 (0.0%) | 0 (0.0%) | 2 (0.2%) | 2 (0.3%) | 0.93 |
Sarcoidosis | 1 (0.1%) | 7 (0.2%) | 4 (0.2%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 3 (0.5%) | 0.43 |
Reactive arthritis | 7 (0.7%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 5 (0.9%) | < 0.01* |
Other connective tissue disease | 1 (0.1%) | 6 (0.2%) | 1 (0.0%) | 0 (0.0%) | 1 (0.3%) | 0 (0.0%) | 2 (0.3%) | 0.23 |
Sjögren’s syndrome | 1 (0.1%) | 5 (0.2%) | 0 (0.0%) | 0 (0.0%) | 2 (0.7%) | 1 (0.1%) | 1 (0.2%) | 0.07 |
Rheumatic fever | 2 (0.2%) | 3 (0.1%) | 1 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (0.1%) | 1 (0.2%) | 0.65 |
Vasculitides | 1 (0.1%) | 0 (0.0%) | 2 (0.1%) | 0 (0.0%) | 1 (0.3%) | 0 (0.0%) | 1 (0.2%) | 0.07 |
Still’s disease | 1 (0.1%) | 1 (0.0%) | 2 (0.1%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0.80 |
FMF | 1 (0.1%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (0.2%) | 0.11 |