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Table 1 Baseline characteristics of randomized patients

From: Economic evaluation of infliximab, synthetic triple therapy and methotrexate in the treatment of newly diagnosed juvenile idiopathic arthritis

 

IFX (N=20)

TRIPLE (N=20)

MTX (N=20)

Female, n (%)

14 (70)

14 (70)

11 (55)

Age (years) mean (SD)

10.5 (3.2)

8.3 (2.7)

9.6 (3.2)

Age of onset of JIA, years

10.5 (3.1)

8.1 (2.7)

10.0 (3.5)

ANAAb positive, n (%)

9 (47)

7 (35)

6 (30)

ESR, mm/h, mean (SD)

28 (20)

41 (33)

39 (30)

JADAS-10

17.1 (4.4)

20.1 (5.0)

21.9 (5.4)

Active joint count, mean (SD)

18 (10)

17 (10)

18 (12)

Physician VAS, mean (SD)

49 (18)

55 (19)

60 (18)

CHAQ

0.49 (0.6)

0.71 (0.6)

1.07 (0.6)

EQ-5D a

 Roche quadratic

0.73 (0.14)

0.78 (0.16)

0.60 (0.15)

 NICE quadratic

0.68 (0.15)

0.62 (0.18)

0.52 (0.18)

 Roche linear

0.75 (0.15)

0.69 (0.18)

0.59 (0.17)

 Boggs et al. linear

0.66 (0.16)

0.60 (0.18)

0.49 (0.18)

  1. IFX Infliximab, TRIPLE Combination of hydroxychloroquine, sulphasalazine, and methotrexate, MTX Methotrexate monotherapy, ANAAb Anti-nuclear antibody, JADAS-10 Juvenile arthritis disease activity score, CHAQ Child Health Assessment Questionnaire, EQ-5D EuroQoL-5D questionnaire. NICE National Institute for Health and Care Excellence. Values are presented as mean (SD)
  2. aUtility values onset are presented as results of different mapping algorithms [18]
  3. NICE quadratic HRQOL = 0.82–0.11*CHAQ-0.07*(CHAQ^2)
  4. Roche quadratic HRQOL = 0.804–0.203*CHAQ-0.045*(CHAQ^2)
  5. Roche linear HRQOL = 0.89–0.28*CHAQ
  6. Boggs et al. linear HRQOL = 0.76–0.28*CHAQ+ 0.05*female