Table 1 (abstract O16). See text for description
From: Proceedings of the 28th European Paediatric Rheumatology Congress (PReS 2022)
Pathway | Gene | Disease associated |
|---|---|---|
IC clearance | C1S | SLE-like disease, aHUS, primary angioedema |
C3 | SLE-like disease | |
PEPD | SLE-like disease | |
Immune cell signalling | BANK1 | AITD, CLL, SSc, RA, SLE |
PTPN22 | RA, T1D, CD, JIA, HT, SLE | |
TNFSF4 | SSc, SLE | |
NFκB signalling | TNFAIP3 | SS, RA, SSc, SLE, A20 haploinsufficiency |
Nucleic acid sensing and processing | DNASE1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, TREX1 | AGS, ChLE |
TLR/IFN signalling | IRF7 | SLE |