Latent classes of early response trajectories to biologics initiation in juvenile idiopathic arthritis: an analysis of four trials

Table 2 Distribution of Baseline Clinical Characteristics in the Early Latent Response Classes of Juvenile Idiopathic Patients Following bDMARDs^a

	Class 1 High baseline AJC, slow response n = 120	Class 2 Low baseline AJC, early and sustained response n = 133	Class 3 Moderate baseline AJC, early and progressive response n = 197	Differences between classes P^b
Median disease duration in years 25th–75th percentile	4.0 (2.0–8.0)	3.7 (2.0–6.9)	4.0 (2.0–8.0)	0.135
Median baseline AJC 25th–75th percentile	40 (32–47)	6 (5–8)	17 (14–20)	< 0.001
Median baseline ESR 25th–75th percentile	38 (23–58)	19 (10–39)	28 (13–45)	< 0.001
Number (%) positive rheumatoid factor	30 (25.0)	31 (23.3)	58 (29.4)	0.003
Number (%) on methotrexate	62 (51.7)	106 (79.7)	131 (66.5)	< 0.001
Number (%) on prednisone	52 (43.3)	52 (39.1)	94 (47.7)	0.002

AJC, active joint counts. ESR, erythrocyte sedimentation rate
^a Only those with a posterior probability of membership in a class ≥0.80 presented in this table
450 (out of 480) participants were classifiable by this rule
The p column represented an overall study population-level comparison, this does not imply significance as a membership predictor between groups. For significance of the above as latent class membership predictors, please refer to Table A2 (Appendix)
^b Continuous variables were compared using Kruskal-Wallis test and categorical variables with chi-square test

ISSN: 1546-0096