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Table 2 Laboratory and treatment characteristics

From: Primary antiphospholipid syndrome in pediatrics: beyond thrombosis. Report of 32 cases and review of the evidence

 

All patients n = 32 (%)

Thrombosis n = 9 (%)

Non-trombotic n = 23 (%)

P value

 Prolonged aPTT

30 (94%)

9 (100%)

21 (91%)

0.36

 Value in seconds (NV = 33 s)

77 (27-124 s)

97 (41-124 s)

69 (27–120)

0.033*

 Lupus anticoagulant (dRVVT)

32 (100%)

9 (100%)

23 (100%)

 

 Value (NV =  < 1.2)

2.07

2.13

2.05

0.71

 Anticardiolipin antibodies

29 (91%)

8 (88%)

21 (91%)

 

 IgG

20 (63%)

6 (66%)

14 (61%)

0.76

 Value (NV < 40)

191 GPL

188 GPL

192 GPL

0.86

 IgM

19 (59%)

4 (44%)

15 (65%)

0.28

 Value (NV < 40)

153 MPL

154 MPL

153 MPL

0.50

 Antibody profile

 LAC

2 (6%)

1 (11%)

1 (4%)

0.47

 LAC + ACL IgG

10 (31%)

4 (44%)

6 (26%)

0.31

 LAC + ACL IgM

8 (25%)

0

8 (35%)

0.041*

 LAC + ACL IgG + IgM

9 (28%)

2 (22%)

7 (30%)

0.64

 LAC + ACL IgM + B2GPI

2 (6%)

2 (22%)

0

 

 LAC + ACL IgG + B2GPI

1 (3%)

0

1 (4%)

 

Treatment

 Anticoagulation

9 (28%)

9 (100%)

0

 

 Antiplatelet

23 (72%)

0

23 (100%)

 

 Steroid

30 (94%)

8 (88%)

22 (96%)

 

 Immunosuppressant

30 (94%)

8 (88%)

22 (96%)

 

 Cyclophosphamide

8 (25%)

6 (66%)

2 (9%)

 

 Mycophenolate

18 (56%)

1 (11%)

17 (74%)

 

 Azathioprine

4 (13%)

1 (11%)

3 (13%)

 

 Rituximab

4 (13%)

2 (22%)

2 (9%)

 
  1. aPTT Activated partial thromboplastin time, LAC Lupus anticoagulant, ACL Anticardiolipin antibodies, NV Normal value, dRVVT Diluted Russell Viper Venom Time