Table 2 Overview of the Metabolites Identified as Significantly Different (adjusted p < 0.05) in Adolescents with Juvenile Arthritis Relative to Controls
Metabolite | Categorya | Integrated Peak Area for JIA Group Relative to Control Group |
|---|---|---|
Alpha-glucose | Hexose—a monosaccharide in which the sugar unit is a six-carbon containing moiety. | ↓ |
Alpha-ketoglutarate (a.k.a. oxoglutaric acid, alpha-ketoglutarate) | Gamma keto acids and derivatives, integral part of the tricarboxylic acid (TCA) cycle, a key part of aerobic metabolism. | ↓ |
Glycine | Nonessential amino acid involved in the body’s production of DNA, phospholipids, and collagen, and in the release of energy. | ↑ |
Cystine | Formed from two cysteine molecules joined together, found in hair, skin, and nails; cysteine is a sulfur-containing alpha amino acid found in most proteins and contains a thiol group. | ↑ |
Serine | Conditionally essential amino acid derived from glycine. | ↓ |
N-acetylaspartate | Derivative of aspartic acid, a nonessential amino acid made from glutamic acid; may provide resistance to fatigue and promote endurance. | ↓ |