|
Still’s onset age < 2.5 years
|
43% (29/67)
|
19% (19/100)
|
8.9 x 10-4
|
3.2 (1.6-6.5)
|
|
Abdominal pain
|
24% (16/67)
|
2% (2/100)
|
9.6 x 10-6
|
15.4 (3.4-70)
|
|
Transfusion (no MAS or bleeding)
|
13% (9/67)
|
0% (0/100)
|
1.9 x 10-4
|
Infinite
|
|
Atypical non-evanescent rash
|
90% (60/67)
|
5% (5/100)
|
2.5 x 10-28
|
98.6 (34-286)
|
|
Absolute eosinophils >700/ul
|
79% (53/67)
|
0% (0/100)
|
7.1 x 10-31
|
infinite
|
| |
DRESS cases
|
Drug-tolerant controls
| |
|
HLA-DRB1*15:XX (all ancestries)
|
79% (56/71)
|
7% (2/30)
|
not applicable across ancestries
|
|
HLA-DRB1*15:01 (White)
|
79% (38/48)
|
0% (0/19)
|
8.2 x 10-10
|
infinite
|
|
Anti-IL-1 exposure
|
96% (68/71)
|
86% (26/30)
|
NS (0.19)
| |
|
Tocilizumab exposure
|
27% (19/71)
|
40% (12/30)
|
NS (0.24)
| |
|
Elevated AST/ALT
|
75% (53/71)
|
13% (4/30)
|
1.1 x 10-8
|
19 (5.9-62)
|
| |
DRESS without DLD
|
DRESS
with
DLD
| |
|
HLA-DRB1*15:XX
|
68% (15/22)
|
84% (41/49)
|
not applicable across ancestries
|
|
MAS during drug
|
59% (12/22)
|
71% (34/49)
|
NS (0.29)
| |
