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Table 1 (abstract P61). See text for description

From: Abstracts from the ISSAID 2021 Periodic Congress

  DRESS cases Institutional controls P value OR (95CI)
Still’s onset age < 2.5 years 43% (29/67) 19% (19/100) 8.9 x 10-4 3.2 (1.6-6.5)
Abdominal pain 24% (16/67) 2% (2/100) 9.6 x 10-6 15.4 (3.4-70)
Transfusion (no MAS or bleeding) 13% (9/67) 0% (0/100) 1.9 x 10-4 Infinite
Atypical non-evanescent rash 90% (60/67) 5% (5/100) 2.5 x 10-28 98.6 (34-286)
Absolute eosinophils >700/ul 79% (53/67) 0% (0/100) 7.1 x 10-31 infinite
  DRESS cases Drug-tolerant controls  
HLA-DRB1*15:XX (all ancestries) 79% (56/71) 7% (2/30) not applicable across ancestries
HLA-DRB1*15:01 (White) 79% (38/48) 0% (0/19) 8.2 x 10-10 infinite
Anti-IL-1 exposure 96% (68/71) 86% (26/30) NS (0.19)  
Tocilizumab exposure 27% (19/71) 40% (12/30) NS (0.24)  
Elevated AST/ALT 75% (53/71) 13% (4/30) 1.1 x 10-8 19 (5.9-62)
  DRESS without  DLD DRESS with DLD  
HLA-DRB1*15:XX 68% (15/22) 84% (41/49) not applicable across ancestries
MAS during drug 59% (12/22) 71% (34/49) NS (0.29)