Table 1 (abstract P61). See text for description
| Â | DRESS cases | Institutional controls | P value | OR (95CI) |
|---|---|---|---|---|
Still’s onset age < 2.5 years | 43% (29/67) | 19% (19/100) | 8.9 x 10-4 | 3.2 (1.6-6.5) |
Abdominal pain | 24% (16/67) | 2% (2/100) | 9.6 x 10-6 | 15.4 (3.4-70) |
Transfusion (no MAS or bleeding) | 13% (9/67) | 0% (0/100) | 1.9 x 10-4 | Infinite |
Atypical non-evanescent rash | 90% (60/67) | 5% (5/100) | 2.5 x 10-28 | 98.6 (34-286) |
Absolute eosinophils >700/ul | 79% (53/67) | 0% (0/100) | 7.1 x 10-31 | infinite |
| Â | DRESS cases | Drug-tolerant controls | Â | |
HLA-DRB1*15:XX (all ancestries) | 79% (56/71) | 7% (2/30) | not applicable across ancestries | |
HLA-DRB1*15:01 (White) | 79% (38/48) | 0% (0/19) | 8.2 x 10-10 | infinite |
Anti-IL-1 exposure | 96% (68/71) | 86% (26/30) | NS (0.19) | Â |
Tocilizumab exposure | 27% (19/71) | 40% (12/30) | NS (0.24) | Â |
Elevated AST/ALT | 75% (53/71) | 13% (4/30) | 1.1 x 10-8 | 19 (5.9-62) |
|  | DRESS without  DLD | DRESS with DLD |  | |
HLA-DRB1*15:XX | 68% (15/22) | 84% (41/49) | not applicable across ancestries | |
MAS during drug | 59% (12/22) | 71% (34/49) | NS (0.29) | Â |