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Table 1 Clinical characteristic and cardiac findings in patients with Multisystem Inflammatory Syndrome in Children in Michigan stratified by ICU admission, April 2020–February 2021

From: A descriptive study on multisystem inflammatory syndrome in children in a single center in West Michigan

Demographic Characteristics
   Total (%) Group 1 (PICU) (%) Group 2 (non-PICU) (%) p values
Total   26 15 11
Age (months) Mean (St Dev) 105.15 (57.3) 99.13 (53.4) 113.36 (64.0) 0.5424
Sex Male 16 (61.5) 7 (46.7) 9 (81.8) 0.1092
Female 10 (38.5) 8 (53.3) 2 (18.2)  
Race White 14 (53.5) 8 (53.3) 6 (54.6)
Black 4 (15.4) 4 (26.7) 0 (0)
Hispanic 3 (11.5) 2 (13.3) 1 (9.1)
Other 3 (11.5) 0 (0) 3 (27.3)
Unknown 2 (7.7) 1 (6.7) 1 (9.1)
BMI Median (IQR) 18.095 (16.1–20.83) 17.7 (16.1–20.06) 19.16 (15.44–22.98) 0.5858
Clinical presentation
 Fever   26 (100) 15 (100) 11(100) 1.0
GI symptoms Vomiting 19 (73.1) 12 (80) 7 (63.6) 0.4065
Diarrhea 14 (53.9) 7 (46.7) 7 (63.6) 0.3912
Abdominal pain 22 (84.6) 14 (93.3) 8 (72.7) 0.2789
 Skin rash   15 (57.7) 8 (53.3) 7 (63.6) 0.7007
Other Kawasaki-like featuresa 17 (65.4) 8 (53.3) 9 (81.8) 0.1315
Cardiac involvement Coronary dilation 12 (46.2) 6 (40) 6 (54.6) 0.4623
Other cardiac changes 15 (57.7) 11 (73.3) 4 (36.4) 0.1089
History of COVID-19 infection/exposure   17 (65.4) 7 (46.7) 10 (90.9) 0.0362*
Cytokine elevationb IL-2 Soluble 8 (50) 4 (40) 4 (66.7) 0.6084
IL-2 Receptor 12 (75) 9 (90) 3 (50) 0.1181
IL-5 2 (12.5) 2 (20) 0 (0) 0.5
IL-6 7 (43.8) 6 (60) 1 (16.7) 0.1451
IL-10 16 (100) 10 (100) 6 (100)  
IL-13 6 (37.5) 5 (50) 1 (16.7) 0.3069
IL-17 5 (31.3) 4 (40) 1 (16.7) 0.5879
TNF-alpha 3 (18.8) 2 (20) 1 (16.7) 1.0
TNF-gamma 6 (37.5) 4 (40) 2 (33.3) 1.0
Positive COVID-19 PCR on admission   11 (42.3) 6 (40) 5 (45.5) 1.0
COVID-19 antibody Anti-Spike 25 (96.2) 15 (100) 10 (90.9) 0.4231
Anti-Nucleocapsid 18 (85.7) 10 (83.3) 8 (88.9) 1.0
Respiratory support Nasal cannula 2 (7.7) 2 (13.3) 0 (0)
BiPap 2 (7.7) 2 (13.3) 0 (0)
Intubated 8 (30.8) 8 (53.3) 0 (0)
  1. BMI Body mass index, IQR interquartile range, GI Gastrointestinal, COVID-19 Coronavirus disease 2019, PCR polymerase chain reaction, IL Interleukin, TNF Tumor necrosis factor, BiPap Bilevel positive airway pressure
  2. a cervical adenopathy, oral mucosa changes, peripheral extremity changes, and/or bilateral non-purulent conjunctivitis
  3. b Incorporated into practice during study period, not universally obtained on all included patients
  4. *significant p value (≤0.05)