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Table 1 Laboratory parameters before treatment with tocilizumab (TCZ), after 6 months and after 12 months from starting TCZ (WBC = White blood cell count; N = Neutrophils; L = Lymphocyte count; Hb = Hemoglobin; PLT = platelet count; CRP = C reactive protein; SLEDAI = Systemic Lupus Erythematosus disease activity index); NA = not available.

From: Tocilizumab for massive refractory pleural effusion in an adolescent with systemic lupus erythematosus

  Baseline 72 h after TCZ 1 month after TCZ 6 months after TCZ 12 months after TCZ Normal value
WBC (x109/L) 4.0 9.91 5.4 4.2 4.4 4.0-13.5
 N (x109/L) 2.0 5.41 2.4 1.42 1.7 1.3–7.9
 L (x109/L) 1.5 3.73 2.5 2.2 2.25 1.0-6.5
Hb (g/dL) 11.2 12.5 13.7 12.5 12.9 13.0–16.0
PLT (x109/L) 259 219 109 208 191 150–450
CRP (mg/dL) 0.6 < 0.03 0.03 0.03 0.03 < 0.5
IgG (g/L) 22.31   8.09 6.16 6.98 5.50–15.80
C3 (g/L) 0.36 0.57 0.71 0.67 0.75 0.90–1.80
C4 (g/L) 0.02 0.03 0.05 0.07 0.14 0.10–0.40
Anti-dsDNA antibody score titer 1:640 NA 1:20 1:10 1:10 < 1:10
Anti-Sm antibody (U/mL) 14480.0 NA 1589.0 496.0 428.0 < 5.0
Anti-U1RNP IgG antibody (U/mL) 370.0 NA 245 145.0 111.0 < 7.0
SLEDAI 14 6 2 2 2 ≤ 4