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Table 2 The preliminary criteria of the main JIA disorders proposed by the Pediatric Rheumatology International Trials Organization (PRINTO) Consensus. The PRINTO classification proposed systemic JIA (sJIA), rheumatoid factor–positive JIA (RF+ JIA), enthesitis/spondylitis-related JIA and early-onset antinuclear antibody–positive (early-onset ANA+) JIA. ANA – antinuclear antibodies, AOSD - adult-onset Still’s disease, Anti-CCP – Anti-Cyclic Citrullinated Peptide, HLA - human leukocyte antigen system, RA – rheumatoid arthritis, RF – rheumatoid factor, y.o. – years old

From: Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches

JIA disorders Early-onset ANA+ JIA RF+ JIA Enthesitis/ spondylitis- related JIA sJIA
Clinical criteria • Arthritis for ≥6 weeks, and
• Early-onset (≤ 6 y.o.)
• Arthritis for ≥6 weeks • Peripheral arthritis and enthesitis, or
• Arthritis or enthesitis, +
≥ 3 months of sacroiliitis, or
• Arthritis or enthesitis + 2 of the following:
- sacroiliac joint tenderness
- inflammatory back pain
- acute anterior uveitis
- history of a SpA in relative
• Fever with exclusion of infectious, neoplastic, autoimmune, or monogenic autoinflammatory diseases, for at least 3 days and reoccurring over 2 weeks
+  2 major criteria or 1 major criterion and 2 minor criteria
Major criteria:
• evanescent erythematous rash
• arthritis
Minor criteria:
- generalized lymphadenopathy and/or hepatomegaly and/or splenomegaly
- serositis
- arthralgia lasting more than 2 weeks
Laboratory criteria • 2 “+” ANA tests with a titer ≥1/160 at least 3 months apart • 2 positive tests for RF at least 3 months apart or
• 1 positive test for anti-CCP
- presence of HLA-B27 antigen - leukocytosis (≥ 15,000/mm3) with neutrophilia
Adult equivalent RF-positive RA Spondyloarthritis AOSD