Table 3 Use of intra-articular steroid injections (IASI) and systemic steroids and adverse events during histoplasmosis treatment. Data for number and timing of IASI and systemic steroids were collected as well as concomitant use of itraconazole. Adverse events were noted
Pt | IASI (months after histoplasmosis diagnosis) | Systemic Steroids (months after histoplasmosis diagnosis) | Concomitant Itraconazole? | Description of Adverse Event |
|---|---|---|---|---|
1 JIA | 3 (7.2) | Intermittent high/burst (5.0 on) | Yes | Red, puffy face (duration unclear) |
2 JIA | 18 (2.4) | Intermittent high/burst (4.3 on) | Yes | 9 + months of weight gain, cushingoid facies, buffalo hump, protruding abdomen with striae, diabetes, adrenal insufficiency, and probable spinal compression fractures. |
3 JIA | 2 (12.4) and 3 (17.9) | No | Yes | None |
4 cSLE | No | Bursts (0, never halted) | Yes | None |
5 JIA | 1 (1.1) | No | Yes | None |
6 JIA | 1 (18.3) | Systemic (15.0) | Yes | < 1 day of sweating, chills, and flushing (allergic reaction*) |
7 JIA | 2 (9.2) | No | Yes | 2.5 + months of cushingoid facies |
8 MCTD | 3 (7.4) | Maintenance (0, never halted) | Yes | None |
9 JIA | 7 (0.8) | No | Yes | Around 9 months of weight gain, increased appetite, moon facies, and protruding abdomen |
Summary: | 89 % received IASI 8.3 (0.8–18.3) | 56 % received systemic steroids 4.3 (0–15.0) | Yes | 44 % experienced non-allergic adverse reactions to steroids* |