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Table 1 Baseline characteristics of study cohort

From: Trajectories of disease courses in the inception cohort of newly diagnosed patients with JIA (ICON-JIA): the potential of serum biomarkers at baseline

 

Oligoarthritis

RF- polyarthritis

RF+ polyarthritis

ERA

PsA

systemic JIA

Undifferentiated arthritis

Number of patients

(% of all patients)

107/266 (40.2%)

87/266 (32.7%)

4/266 (1.5%)

30/266 (11.3%)

13/266 (4.9%)

10/266 (3.8%)

15/266 (5.6%)

Number of girls

(% within category)

82/107 (76.6%)

70/87 (80.4%)

3/4 (75%)

8/30 (26.6%)

9/13 (69.2%)

4/10 (40.0%)

10/15 (66.6%)

Age in years at diagnosis, median (range)

5.0 (0.5–15.6)

6.1 (1.0–16.2)

10.9 (8.5–12.0)

10.8 (1.4–16.1)

10.2 (1.4–15.7)

5.9 (0.9–13.4)

8.1 (3.0–14.6)

Duration of symptoms in months, median (range)

8.2 (0.0–57.1)

10.4 (0.6–139.6)

6.5 (1.0–9.7)

12.5 (1.2–70.1)

7.8 (2.2–14.0)

5.2 (1.4–10.7)

10.1 (0.4–31.2)

Duration between diagnosis and enrollment in days, median (range)

42 (0–327)

28 (0–363)

110 (1–142)

76 (0–363)

62 (6–232)

72 (7–327)

42 (3–261)

cJADAS-10, median (range)

8.45 (2–18.5)

13.7 (1.5–27)

8.62 (4–14.5)

10.45 (2.5–22)

14.3 (4–23.5)

14.25 (2–24.5)

11.5 (1.5–22.5)

Active joint count, median (range)

1.8 (0–7)*

9.9 (0–57)

3 (2–5)

3.6 (0–16)

8.2 (0–29)

11.4 (0–57)

5.9 (1–31)

CRP in mg/l, median (range)

6.53 (0–100)

10.8 (0–124)

0.57 (0–1.1)

9.56 (0–65)

4.8 (0–15)

47.87 (4.7–96.8)

17.2 (0–53)

Number of patients with previous medications (% within category)

 Synthetic DMARDs

54/107 (50.5%)

65/87 (74.7%)

3/4 (75%)

14/30 (46.7%)

8/13 (61.5%)

7/10 (70%)

5/15 (33.3%)

 Systemic glucocorticoids, current

19/107 (17.8%)

41/87 (47.1%)

1/4 (25%)

6/30 (20%)

7/13 (53.8%)

10/10 (100%)

3/15 (20%)

 Systemic glucocorticoids, last 6 months before baseline

20/107 (18.7%)

27/87 (31.03%)

1/4 (25%)

7/30 (23.4%)

6/13 (46.1%)

7/10 (70%)

4/15 (26.7%)

 Intraarticular glucocorticoids, last 6 months before baseline

62/107 (57.9%)

47/87 (54.02%)

1/4 (25%)

8/30 (26.7%)

3/13 (23.1%)

3/10 (30%)

6/15 (40%)

 Biologic DMARDs

2/107 (1.9%)

ADA - 2

2/87 (2.3%)

ETN - 2

0 (0.0%)

3/30 (10%)

ETN - 3

1/13 (7.7%)

ETN - 1

3/10 (30.0%)

ANA – 1

CAN – 1

TCZ – 1

1/15 (6.7%)

ETN - 1

 Treatment naive

27/107 (25.2%)

7/87 (8.0%)

 

12/30 (40.0%)

3/13 (23.1%)

 

5/15 (33.3%)

  1. Abbreviations: ADA adalimumab; ANA anakinra; CAN canakinumab; CRP C-reactive protein; DMARD disease-modifying antirheumatic drug; ERA enthesitis-related arthritis; ETN etanercept; JADAS juvenile arthritis disease activity score; PsA psoriatic arthritis; RF rheumatoid factor; TCZ tocilizumab
  2. *4 patients had already developed extended oligoarthritis (≥5 affected joints) at baseline: 3 patients had 5 active joints, 1 patient had 7 active joints