Skip to main content

Table 4 Bone remodeling factors in JDM patients and controls

From: Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study

  Patients (n = 55–58) Controls (n = 55–58) p-values
CTX, ug/l 0.51 (0.34–0.97) 0.46 (0.30–0.96) 0.34
P1NP, ug/l 73.0 (46.8–318.0) 75.0 (52.8–352.0) 0.63
25-OH-VitD, nmol/l 54.0 (37.0–65.0) 65.0 (45.0–83.0) 0.001
Low 25(OH)VitD (<  37 nmol/l), n 13 (22.4) 4 (6.9) 0.08
Insufficient 25(OH)VitD (<20nmo/l), n 3 (5.5) 0 (0) 0.02
Calsium, nmol/l 2.29 (2.24–2.33) 2.33 (2.29–2.39) 0.001
iCalsium, nmol/l 1.25 (0.04) 1.25 (0.03) 0.83
Albumin, g/l 44.5 (2.3) 45.9 (2.3) 0.002
Alkaline phosphatase, U/l 71.0 (56.0–147.3) 72.00 (55.0–150.8) 0.97
Phosphate, nmol/l 1.23 (0.25) 1.13 (0.21) 0.005
PTH, pmol/l 3.52 (1.19) 3.53 (1.27) 0.95
E-SR, mm/h 5.0 (3.0–9.0) 4.0 (3.0–8.0) 0.06
hsCRP, mg/l 0.98 (0.28–2.6) 0.59 (0.23–1.27) 0.12
IP-10, pg/ml 1009 (911–1581) 969 (751–1187) 0.04
Age < 20 y (n = 25–28) (n = 25–28)  
CTX, ug/l 0.94 (0.55–1.39) 0.97 (0.49)1.22 0.73
P1NP, ug/l 326.0 (95.0–560.78) 397.0 (95.0–608.7) 0.77
25-OH-VitD, nmol/l 55.4 (19.0) 66.2 (24.4) 0.11
Low 25(OH)VitD (< 37 nmol/l), n 6 (21.4) 2 (7.1) 0.31
Insufficient 25-OH-VitD (<20 nmol/l), n 1 (3.7) 0 (0) 0.13
Calsium, nmol/l 2.3 (0.2) 2.3 (0.01) 0.18
iCalsium, nmol/l 1.26 (0.03) 1.26 (0.03) 0.75
Albumin, g/l 44.8 (2.1) 45.8 (2.1) 0.10
Alkaline phosphatase, U/l 149.5 (74.3–226.8) 152.5 (76.5–194.8) 0.60
Phosphate, nmol/l 1.35 (0.23) 1.23 (0.23) 0.005
PTH, pmol/l 3.55 (1.23) 3.32 (1.28) 0.50
E-SR, mm/h 4.50 (3.00–8.25) 4.50 (3.00–10.50) 0.44
hsCRP, mg/l 0.40 (0.24–2.44) 0.35 (0.19–1.27) 0.43
IP-10, pg/ml 982 (855–1479) 889 (732–1125) 0.14
Age ≥ 20 y (n = 28–30) (n = 28–30)  
CTX, ug/l 0.40 (0.24–0.49) 0.32 (0.23–0.41) 0.16
P1NP, ug/l 55.0 (41.8–59.0) 59.0 (42.8–68.0) 0.23
25(OH)VitD, nmol/l 47.3 (17.2) 65.3 (21.4) 0.001
Low 25(OH)VitD (< 0.37 nmol/l), n 7 (23.3) 2 (6.7) 0.15
Insufficient 25(OH)VitD (<20 nmol/l), n 2 (7.1) 0 (0) 0.07
Calsium, nmol/l 2.25 (0.11) 2.34 (0.09) 0.002
iCalsium, nmol/l 1.24 (0.04) 1.24 (0.03) 0.62
Albumin, g/l 44.3 (2.5) 46.0 (2.5) 0.004
Alkaline phosphatase, U/l 61.0 (49.0–73.3) 59.0 (50.0–70.5) 0.66
Phosphate,nmol/l 1.10 (0.22) 1.03 (0.17) 0.15
PTH, pmol/l 3.5 (1.17) 3.73 (1.44) 0.48
E-SR, mm/h 7.0 (3.0–8.5) 4.0 (3.0–8.0) 0.08
hsCRP, mg/l 1.07 (0.43–3.5) 0.63 (0.33–1.27) 0.15
IP-10, pg/ml 1066 (940–1593) 1041 (764–1201) 0.14
  1. CTX C-terminal collagen crosslinks, P1NP pro-collagen type 1 N-terminal pro-peptide, 25-OH-VitD 25-hydroxyvitamin D, insufficient 25(−OH)-VitD <20 nmol/l; Low 25(OH)VitD, n < 37 nmol/l; iCalsium: ionized calcium, PTH parathyroid hormone, E-SR erythrocyte sedimentation rate, hsCRP high sensitive C-reactive protein, IP-10 Interferon gamma-induced protein 10. Values are mean (SD) or median (IQR). P-values when comparing patients and controls using independent samples t-test or chi-square for nonparametric values