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Table 5 Fecal SCFAs in children sampled when treatment-naïve and during treatment with MTX or ETN

From: Fecal microbiota in children with juvenile idiopathic arthritis treated with methotrexate or etanercept

SCFAs (mmol/L) Treatment-naïve (n = 15) MTX (n = 15) p value* Treatment-naïve (n = 7) ETN (n = 7) P value*
Acetate 58.6 (36.9) 49.1 (26.0) 0.57 47.5 (25.1) 43.2 (18.4) 0.61
Propionate 14.4 (7.0) 12.4 (7.0) 0.50 13.9 (8.0) 15.3 (9.1) 0.74
Isobutyrate 1.6 (1.0) 2.1 (1.4) 0.02 3.0 (4.1) 1.1 (0.6) 0.75
Butyrate 17.7 (13.9) 15.0 (10.9) 0.53 14.5 (11.8) 17.1 (10.8) 0.61
Valerate 4.3 (3.0) 4.6 (2.7) 0.44 4.8 (2.2) 5.7 (2.7) 0.50
  1. Data are mean (SE), unless otherwise indicated
  2. *Wilcoxon signed-rank test
  3. SCFAs Short-chain fatty acids, MTX Methotrexate, ETN Etanercept, SE Standard error of the mean