Fecal microbiota in children with juvenile idiopathic arthritis treated with methotrexate or etanercept

Table 4 Differences in relative abundances of taxa in children sampled when treatment-naïve and during treatment with MTX or ETN

Taxa influenced by medical treatment†	Treatment-naïve	On medical treatment	Crude p value*	Adjusted p value**
MTX in 15 children:
Rikenellaceae (F)	0.043 (0.023)	0.029 (0.024)	0.02	0.53
Veillonellaceae (F)	0.017 (0.019)	0.011 (0.014)	0.03	0.36
Bacteroidales_S24-7_group (F)	0.005 (0.009)	0.002 (0.006)	0.04	0.33
Alistipes (G)	0.043 (0.023)	0.028 (0.024)	0.02	1
Prevotellaceae_NK3B31_group (G)	0.031 (0.068)	0.009 (0.026)	0.04	1
ETN in 7 children:
No significant differences	–	–	–	–

^†Selected list of taxa with crude p value < 0.05. Data are mean (SE), unless otherwise indicated
*P values calculated using Wilcoxon signed-rank test
**False discovery rate control using the Benjamini-Hochberg procedure
JIA Juvenile idiopathic arthritis, MTX Methotrexate, ETN Etanercept, RF Rheumatoid factor, F Family, G Genus, SE Standard error of the mean

ISSN: 1546-0096