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Table 4 Differences in relative abundances of taxa in children sampled when treatment-naïve and during treatment with MTX or ETN

From: Fecal microbiota in children with juvenile idiopathic arthritis treated with methotrexate or etanercept

Taxa influenced by medical treatment† Treatment-naïve On medical treatment Crude p value* Adjusted p value**
MTX in 15 children:
Rikenellaceae (F) 0.043 (0.023) 0.029 (0.024) 0.02 0.53
Veillonellaceae (F) 0.017 (0.019) 0.011 (0.014) 0.03 0.36
Bacteroidales_S24-7_group (F) 0.005 (0.009) 0.002 (0.006) 0.04 0.33
Alistipes (G) 0.043 (0.023) 0.028 (0.024) 0.02 1
Prevotellaceae_NK3B31_group (G) 0.031 (0.068) 0.009 (0.026) 0.04 1
ETN in 7 children:
 No significant differences
  1. Selected list of taxa with crude p value < 0.05. Data are mean (SE), unless otherwise indicated
  2. *P values calculated using Wilcoxon signed-rank test
  3. **False discovery rate control using the Benjamini-Hochberg procedure
  4. JIA Juvenile idiopathic arthritis, MTX Methotrexate, ETN Etanercept, RF Rheumatoid factor, F Family, G Genus, SE Standard error of the mean