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Fig. 2 | Pediatric Rheumatology

Fig. 2

From: Single nucleotide polymorphisms associated with methotrexate-induced nausea in juvenile idiopathic arthritis

Fig. 2

Illustration of the intracellular effects of methotrexate-polyglutamates including the role of the MTHFR enzyme. dUMP; deoxyuridine monophosphate. dTMP; deoxythymidine monophosphate. TYMS; thymidylate synthase. MTX-PG; methotrexate polyglutamates. DHFR; dihydrofolate reductase. DHF; dihydrofolate. THF; tetrahydrofolate. 5-CH3-THF; 5-methyltetrahydrofolate. 5,10-CH2-THF; 5,10-methylenetetrahydrofolate. MTHFR; methylenetetrahydrofolate reductase. ATIC; AICAR formyltransferase. AICAR; 5-aminoimidazole 4-carboxamide ribonucleotide. FAICAR; 10-formyl AICAR. IMP; inosine monophosphate. AMP; adenosine monophosphate

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