Table 3 Comparison of DADA2 patients between China and other countries
From: Diagnosis and management of adenosine deaminase 2 deficiency children: the experience from China
|  | DADA2 patients from China (n = 7) | DADA2 patients from Other countries ref. 2(n = 161) | P Value |
|---|---|---|---|
Gender M: F | 57%: 43% | 53%: 47% | – |
Onset age < 1y | 3 (42%) | 38 (24%) | NS |
Fever | 7 (100%) | 81 (50%) | 0.014 |
Skin manifestations | 7 (100%) | 121 (75%) | NS |
Livedo reticularis | 6 (86%) | 81 (50%) | NS |
Digital necrosis | 1 (14%) | 36 (22%) | NS |
Aphtous ulcers | 1 (14%) | 11 (7%) | NS |
CNS ischemic stroke | 2 (29%) | 43 (27%) | NS |
CNS hemorrhagic stroke | 1 (14%) | 19 (12%) | NS |
Abdominal pain | 3 (43%) | 19 (12%) | 0.048 |
Splenomegaly | 0 (0%) | 47 (29%) | NS |
Hepatomegaly | 0 (0%) | 31 (19%) | NS |
Nephrological manifestations | 2 (29%) | 23 (14%) | NS |
Hypertension | 1 (14%) | 34 (21%) | NS |
Arthritis | 2 (29%) | 23 (14%) | NS |
Neutropenia | 0 (0%) | 11 (7%) | NS |
Anemia | 2 (29%) | 21 (13%) | NS |
Lymphopenia | 0 (0%) | 26 (16%) | NS |
Hypogammaglobulinemia | 2 (29%) | 36 (22%) | NS |
Low IgM | 3 (42%) | 29 (18%) | NS |
Low IgA | 0 (0%) | 19 (12%) | NS |