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Table 3 Comparison of DADA2 patients between China and other countries

From: Diagnosis and management of adenosine deaminase 2 deficiency children: the experience from China

  DADA2 patients from China
(n = 7)
DADA2 patients from Other countries
ref. 2(n = 161)
P Value
Gender M: F 57%: 43% 53%: 47%
Onset age < 1y 3 (42%) 38 (24%) NS
Fever 7 (100%) 81 (50%) 0.014
Skin manifestations 7 (100%) 121 (75%) NS
Livedo reticularis 6 (86%) 81 (50%) NS
Digital necrosis 1 (14%) 36 (22%) NS
Aphtous ulcers 1 (14%) 11 (7%) NS
CNS ischemic stroke 2 (29%) 43 (27%) NS
CNS hemorrhagic stroke 1 (14%) 19 (12%) NS
Abdominal pain 3 (43%) 19 (12%) 0.048
Splenomegaly 0 (0%) 47 (29%) NS
Hepatomegaly 0 (0%) 31 (19%) NS
Nephrological manifestations 2 (29%) 23 (14%) NS
Hypertension 1 (14%) 34 (21%) NS
Arthritis 2 (29%) 23 (14%) NS
Neutropenia 0 (0%) 11 (7%) NS
Anemia 2 (29%) 21 (13%) NS
Lymphopenia 0 (0%) 26 (16%) NS
Hypogammaglobulinemia 2 (29%) 36 (22%) NS
Low IgM 3 (42%) 29 (18%) NS
Low IgA 0 (0%) 19 (12%) NS
  1. CNS Central nervous system, NS No significance