Table 2 Clinical and laboratory characteristics of patients with CNO (n = 44)
Characteristic | Number (%) | Median (range) |
|---|---|---|
Female | 32 (72.8) | |
Age at onset | 9.2 years (3.1–14.3) | |
Age at diagnosis | 10.5 years (5.9–15.5) | |
Diagnostic delay | 0.7 years (0.1–2) | |
Duration of follow-up Presenting symptom: | 3.03 years (0.64–8.47) | |
• Pain | 44 (100) | |
• Fever | 6 (13.6) | |
• Clinically unifocal | 23 (52.3) | |
Total sites (clinical and radiological) | 4 (1–19) | |
Unifocal disease | 4 (9.1) | |
Extraosseous involvement: | ||
• Arthritisa | 9 (20.5) | |
• Psoriasis | 9 (20.5) | |
• Pustulosis | 4 (9.1) | |
• Aphthous ulceration | 4 (9.1) | |
• Severe acne | 2 (4.6) | |
• Pyoderma gangrenosum | 2 (4.6) | |
• Hidradenitis suppurativa | 1 (2.3) | |
• Inflammatory bowel disease | 1 (2.3) | |
Elevated inflammatory markers at presentation | ||
• ESR | 26 (59.1) | |
• CRP | 10 (22.7) | |
HLA B27 (n = 38) | 6 (15.7) | |
ANA positive > 1:160 (n = 38) | 4 (10.5) | |
Bone biopsy | 34 (77.3) | |
Family history: | ||
• Psoriasis | 19 (43.2) | |
• Inflammatory bowel disease | 7 (15.9) | |
• Inflammatory arthritis | 9 (20.5) | |