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Table 2 Clinical and laboratory characteristics of patients with CNO (n = 44)

From: Variability in phenotype and response to treatment in chronic nonbacterial osteomyelitis; the Irish experience of a national cohort

Characteristic Number (%) Median (range)
Female 32 (72.8)  
Age at onset   9.2 years (3.1–14.3)
Age at diagnosis   10.5 years (5.9–15.5)
Diagnostic delay   0.7 years (0.1–2)
Duration of follow-up
Presenting symptom:
  3.03 years (0.64–8.47)
 • Pain 44 (100)  
 • Fever 6 (13.6)  
 • Clinically unifocal 23 (52.3)  
Total sites (clinical and radiological)   4 (1–19)
Unifocal disease 4 (9.1)  
Extraosseous involvement:
 • Arthritisa 9 (20.5)  
 • Psoriasis 9 (20.5)  
 • Pustulosis 4 (9.1)  
 • Aphthous ulceration 4 (9.1)  
 • Severe acne 2 (4.6)  
 • Pyoderma gangrenosum 2 (4.6)  
 • Hidradenitis suppurativa 1 (2.3)  
 • Inflammatory bowel disease 1 (2.3)  
Elevated inflammatory markers at presentation
 • ESR 26 (59.1)  
 • CRP 10 (22.7)  
HLA B27 (n = 38) 6 (15.7)  
ANA positive > 1:160 (n = 38) 4 (10.5)  
Bone biopsy 34 (77.3)  
Family history:
 • Psoriasis 19 (43.2)  
 • Inflammatory bowel disease 7 (15.9)  
 • Inflammatory arthritis 9 (20.5)  
  1. aArthritis distant from CNO lesions