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Fig. 2 | Pediatric Rheumatology

Fig. 2

From: Growth and puberty in children with juvenile idiopathic arthritis

Fig. 2

Effects of pro-inflammatory cytokines and of GCs on gonadotropin-gonads axis as well as on bone metabolism. IL-6 (Interleukin-6); IL-1β (Interleukin-1β); TNFα (Tumor Necrosis Factor-α); GCs (glucocorticoids); GnRH (gonadotropin releasing hormone); LH (luteinizing hormone); FSH (follicle stimulating hormone); RFRP-3 (RFamide-related peptide); Kiss-1 (kipeptin-1); OPG (osteoprotegerin); RANKL (nuclear factor kappa β ligand); DKK-1 (dickkopf-1)

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