Predictive value of C-reactive protein to albumin ratio as a biomarker for initial and repeated intravenous immunoglobulin resistance in a large cohort of Kawasaki disease patients: a prospective cohort study

Table 2 A multivariate logistic regression analysis for predicting initial IVIG resistance in KD

Model 1	β	SE	Walds	P value	OR	95% CI	Points
Age ≥ 48 months	0.000	0.006	0.001	0.976	1.000	0.989–1.011
Cervical lymphadenopathy	−0.245	0.272	0.815	0.367	0.782	0.459–1.333
NLR ≥ 2.91	0.584	0.354	2.720	0.099	1.794	0.896–3.592
PLR ≥ 134	0.260	0.303	0.736	0.391	1.297	0.716–2.351
CAR≥2.07	0.762	0.321	5.629	0.018	2.142	1.142–4.019	5.0
TBil≥9.5 μmol/L	0.566	0.282	4.040	0.044	1.761	1.014–3.058	3.5
Na⁺ ≤ 135.7 mmol/L	−0.729	0.270	7.322	0.007	0.482	0.284–0.818	4.5
Intercept	1.214	0.425	8.174	0.004	3.366	–
Model 2
Age ≥ 48 months	0.425	0.317	1.793	0.181	1.529	0.821–2.848
Cervical lymphadenopathy	−0.237	0.272	0.758	0.384	0.789	0.463–1.345
NLR ≥ 2.91	0.452	0.354	1.628	0.202	1.571	0.785–3.146
PLR ≥ 134	0.249	0.305	0.669	0.413	1.283	0.706–2.331
CRP ≥ 57.7 mg/L	0.567	0.324	3.062	0.080	1.762	0.934–3.325
ALB≤34.1 g/L	−0.698	0.276	6.398	0.011	0.497	0.290–0.855	5.0
TBil≥9.5 μmol/L	0.589	0.287	4.227	0.040	1.803	1.028–3.162	4.0
Na⁺ ≤ 135.7 mmol/L	−0.670	0.274	6.007	0.014	0.512	0.299–0.874	4.5
Intercept	1.160	0.441	6.931	0.008	3.191	–

Abbreviations: ALB Albumin; CRP C-reactive protein; CAR C-reactive protein-to-albumin ratio; IVIG Intravenous immunoglobulin; KD Kawasaki disease; NLR Neutrophil-lymphocyte ratio; Na⁺ Sodium; PLR Platelet-lymphocyte ratio; TBil Total bilirubin;

ISSN: 1546-0096