Fig. 2

Abnormalities in laboratory findings. a lymphopenia. b Elevated CRP, ESR, and SAA levels. c Immunoglobulin levels showing intermediate elevated IgM and IgA levels. d Reduced C3 and C4 levels. e Persistently elevated levels of urine β2 macroglobulin. f Intermediate mild abnormalities in Cr and BUN. The normal reference ranges are as follows: lymphocytes (800 ~ 4000 cells/ul); CRP (0 ~ 10 mg/L); ESR (0 ~ 20 mm/h); SAA (0 ~ 6 mg/L); IgG (5.28 ~ 21 g/L); IgM (0.48 ~ 2.26 g/L); IgA (0.44 ~ 3.99 g/L); C3 (0.7 ~ 2.06 g/L); C4 (0.11 ~ 0.61 g/L); urine β2 macroglobulin (0 ~ 0.3 mg/L); GFR (80 ~ 120 ml/min). Single arrow and double arrows labeled the time when tocilizumab was started and discontinued, respectively. The asterisk labeled the time when tofacitinib was started