Integrin α2 gene polymorphism is a risk factor of coronary artery lesions in Chinese children with Kawasaki disease

Table 2 Genotype frequency distribution of the rs1126643 polymorphism in KD cases with the CAL and NCAL

Genotype	CAL (n = 300)	NCAL (n = 485)	P-value^a	OR (95% CI)	P-value	Adjusted OR (95% CI)	Adjusted P-value^b
ITGA2/rs1126643 C > T
CC	138 (46.00%)	273 (56.29%)		1.00		1.00
CT	146 (48.67%)	182 (37.53%)		1.59 (1.18–2.14)	0.0025	1.57 (1.16–2.12)	0.0032
TT	16 (5.33%)	30 (6.19%)		1.06 (0.56–2.00)	0.8697	1.03 (0.54–1.95)	0.9374
Additive			0.0089	1.29 (1.02–1.64)	0.0342	1.28 (1.01–1.62)	0.0443
Dominant	162 (54.00%)	212 (43.71%)	0.0050	1.51 (1.13–2.02)	0.0051	1.49 (1.12–2.00)	0.0068
Recessive	284 (94.67%)	455 (93.81%)	0.6193	0.85 (0.46–1.60)	0.6216	0.83 (0.45–1.56)	0.5675
C	422 (70.33%)	728 (75.05%)	0.0409	1.00		1.00
T	178 (29.67%)	242 (24.95%)		1.63 (1.08–2.47)	0.0194	1.66 (1.10–2.51)	0.0165

^a Two-sided χ2 test for distributions between Kawasaki disease patients with the CAL and NCAL. ^b Adjusted for age and sex status in logistic regress models

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