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Table 1 Baseline demographics and disease characteristics of patients who participated in the vaccination substudy and of those who did not

From: Maintenance of antibody response to diphtheria/tetanus vaccine in patients aged 2–5 years with polyarticular-course juvenile idiopathic arthritis receiving subcutaneous abatacept

 Participated
n = 29
Did not participate
n = 17
Total cohort 2a
n = 46
Age at enrolment, years4.2 (0.9)3.8 (1.2)4.1 (1.0)
Female, n (%)16 (55.2)12 (70.6)28 (60.9)
Weight, kg18.4 (3.6)18.0 (3.5)18.2 (3.5)
Weight categories, kg, n (%)
  < 2527 (93.1)16 (94.1)43 (93.5)
 25–502 (6.9)1 (5.9)3 (6.5)
  ≥ 50000
Race, n (%)
 White29 (100.0)15 (88.2)44 (95.7)
 Black/African American01 (5.9)1 (2.2)
 Other01 (5.9)1 (2.2)
Geographic region, n (%)
 South America4 (13.8)4 (23.5)8 (17.4)
 Europe25 (86.2)11 (64.7)36 (78.3)
 Rest of world02 (11.8)2 (4.3)
Duration of JIA, years0.8 (1.0)0.8 (1.0)0.8 (1.0)
JIA disease onset categories, n (%)
 Polyarthritis RF−18 (62.1)12 (70.6)29 (63.0)
 Polyarthritis RF+02 (11.8)3 (6.5)
 Extended oligoarthritis8 (27.6)2 (11.8)10 (21.7)
 Psoriatic arthritis3 (10.3)1 (5.9)4 (8.7)
No. of active joints10.0 (6.4)8.1 (5.2)9.3 (6.0)
No. of joints with limitation of motion9.6 (5.9)7.1 (4.8)8.7 (5.6)
CHAQ-DI score1.0 (0.7)1.2 (0.6)1.1 (0.7)
Parent global assessment score37.0 (22.9)41.4 (26.0)38.6 (23.9)
Physicians global assessment score50.2 (16.1)41.9 (20.4)47.1 (18.0)
CRP, mg/dL0.8 (1.4)2.3 (3.4)1.3 (2.4)
MTX dose ay Day 1, mg/m2/weekn = 22
13.5 (4.5)
n = 14
12.0 (2.3)
n = 37
12.9 (3.8)
Prednisone dose at Day 1, mg/kg/dayn = 3
0.2 (0.0)
n = 5
0.3 (0.2)
n = 8
0.2 (0.1)
  1. Data are mean (SD) unless otherwise specified. Baseline is Day 1 of the study or the last measurement prior to short-term dose. Cohort 2 included all patients aged 2–5 years. Minor differences between the data for total cohort 2 and those for the participated patients and patients who did not participate in the substudy are due to the different dates of database lock (participated patients and patients who did not participate: July 2, 2018; total cohort 2: February 16, 2017)
  2. aIncludes all patients who did or did not participate in the vaccination substudy
  3. CHAQ-DI Childhood Health Assessment Questionnaire-Disability Index, CRP C-reactive protein, JIA juvenile idiopathic arthritis, MTX methotrexate, RF rheumatoid factor
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