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Table 1 Levels of Serum S100A8/9, S100A12 and CRP by diagnoses with pediatric rheumatic diseases during active disease

From: The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis

 

sJIA

N = 21

nsJIA

N = 49

AID

N = 8

SURFS

N = 14

p value

S100A8/9 (ng/ml)

N = 19

31,465

(3708, 47,172)

N = 48

1471

(765, 2589)

N = 8

1352

(893, 5548)

N = 14

2224

(1842, 4175)

< 0.0001

S100A12 (ng/ml)

N = 21

2075

(278, 5612)

N = 36

100

(55, 218)

N = 7

80

(54, 544)

N = 12

130

(108, 259)

< 0.0001

CRP (mg/dL)

N = 15

2.7

(0.7, 12.6)

N = 34

0.1

(0.1, 0.7)

N = 6

1.3

(0.1, 4.5)

N = 7

0.1

(0.1, 3.5)

0.0016

INACTIVE

N = 12

N = 23

N = 5

N = 4

N/A

  1. Comparisons between groups of diagnoses are done by Kruskal-Wallis test. Values shown as median (inter-quantile range). Abbreviations: nsJIA non-systemic juvenile idiopathic arthritis, sJIA systemic juvenile idiopathic arthritis, AID autoinflammatory disease, SURFS systemic undifferentiated recurring fever syndromes, CRP C-reactive protein. The normal range of S100A8/9 per this assay is 716–3004, while that for S100A12 is 32–385
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Pediatric Rheumatology

ISSN: 1546-0096