Fig. 5From: Type I interferonopathies with novel compound heterozygous TREX1 mutations in two siblings with different symptoms responded to tofacitinibHistopathological findings of a skin lesion of the proband. Histopathological examination showed significant hyperkeratosis and acanthosis. There were lymphocyte-dominated inflammatory infiltration at the dermal junction and around the dermal vessels and adnexa, and neovascularisation in the dermal papilla (H&E, × 100)Back to article page