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Fig. 5 | Pediatric Rheumatology

Fig. 5

From: Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation

Fig. 5

Using ELISA to study the effects of exogenous BMP4 on protein expression of markers of chondrocyte differentiation. Exogenous BMP4 causes a significant decrease in COL2 in JFLS (a) (p < 0.05) and an increase in COLX in both CFLS and JFLS (B) (p < 0.05). CFLS and JFLS, in the presence of BMP4, overexpress bone-derived alkaline phosphatase (ALP), a marker secreted by bone cells and hypertrophic chondrocytes (c) (p < 0.05)

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Pediatric Rheumatology

ISSN: 1546-0096