Skip to main content

Table 3 Estimates of factors associated with pain over time in mixed-effects models in pre-intervention and Phase I implementation cohorts

From: Determinants of disease activity change over time in Enthesitis related arthritis: effect of structured outcome monitoring and clinical decision support

 

Univariate*

Multivariate

β (95% CI)

p-value

β (95% CI)

p-value

Male Sex

−1.74 (− 2.22,-1.26)

< 0.01

− 0.49 (− 0.83,-0.15)

< 0.01

Public insurance

0.37 (− 0.14,0.87)

0.16

Baseline pain

0.58 (0.51,0.65)

< 0.01

0.38 (0.31,0.45)

< 0.01

Incident diagnosis*

0.91 (0.26,1.37)

< 0.01

− 0.59 (− 0.94,-0.24)

< 0.01

cJADAS #

0.39 (0.35,0.43)

< 0.01

0.31 (0.27,0.35)

< 0.01

Time (in months)

−0.02 (− 0.05, 0.01)

0.28

0.00 (− 0.02, 0.02)

0.65

Tender entheses count #

0.38 (0.29,0.48)

< 0.01

DMARD use #

0.09 (− 0.45,0.63)

0.73

Biologic use

− 0.37 (− 0.83,0.09)

0.12

Pre-intervention vs Phase I cohort

0.49 (− 0.09,1.07)

0.10

Pre/post Phase I cohort * time interaction^

−0.03 (− 0.17,0.11) p

0.67

  1. * Marginal effect of each covariate on the repeated measured JADAS over time. # Repeated measures collected at every visit. Interaction term represents whether there is a significant difference in slope/rate of change over time in those before and after the polyarticular CDS intervention
  2. Abbreviations. cJADAS clinical Juvenile Arthritis Disease Activity Score, CDS clinical decision support tool, VAS visual analogue scale, DMARD Disease Modifying Anti Rheumatic Drug